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Eccrine porocarcinoma

MedGen UID:
266098
•Concept ID:
C1266065
•
Neoplastic Process
Synonyms: Eccrine Porocarcinoma; Eccrine Porocarcinomas; Eccrine Poroma, Malignant; Eccrine Poromas, Malignant; Malignant Eccrine Poroma; Malignant Eccrine Poromas; Porocarcinoma, Eccrine; Porocarcinomas, Eccrine; Poroma, Malignant Eccrine; Poromas, Malignant Eccrine
SNOMED CT: Porocarcinoma (128685001); Eccrine poroma, malignant (128685001); Eccrine porocarcinoma of skin (254708001); Eccrine porocarcinoma (254708001); Eccrine porocarcinoma (128685001)
 
Monarch Initiative: MONDO:0006189

Definition

A carcinoma with eccrine differentiation arising from the sweat glands. It may arise de novo or as a malignant transformation of a pre-existing poroma. It usually grows in the legs, buttocks, feet, and trunk and usually presents as an ulcerative plaque. It is characterized by the presence of intraepidermal and dermal nests of malignant epithelial cells. It may recur after excision and metastasize to the lymph nodes and less frequently to distal anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Eccrine porocarcinoma

Professional guidelines

PubMed

Intraepidermal Poroma (Hidroacanthoma Simplex) Versus Clonal Seborrheic Keratosis: Will GATA3 Immunohistochemistry Help in the Differential Diagnosis?
Schukow C, McCalmont TH, Surprenant D, Yang HH
Am J Dermatopathol 2023 Oct 1;45(10):728-730. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002503. PMID: 37506277

Recent clinical studies

Etiology

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Eccrine Porocarcinoma: New Insights and a Systematic Review of the Literature.
Nazemi A, Higgins S, Swift R, In G, Miller K, Wysong A
Dermatol Surg 2018 Oct;44(10):1247-1261. doi: 10.1097/DSS.0000000000001566. PMID: 29894433
Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review.
Tidwell WJ, Mayer JE, Malone J, Schadt C, Brown T
Int J Dermatol 2015 Sep;54(9):1078-83. Epub 2015 Jul 23 doi: 10.1111/ijd.12997. PMID: 26205087
Nonmelanoma skin cancer.
Dubas LE, Ingraffea A
Facial Plast Surg Clin North Am 2013 Feb;21(1):43-53. doi: 10.1016/j.fsc.2012.10.003. PMID: 23369588
Eccrine porocarcinoma.
Goedde TA, Bumpers H, Fiscella J, Rao U, Karakousis CP
J Surg Oncol 1994 Apr;55(4):261-4. doi: 10.1002/jso.2930550413. PMID: 8159010

Diagnosis

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Eccrine Porocarcinoma: New Insights and a Systematic Review of the Literature.
Nazemi A, Higgins S, Swift R, In G, Miller K, Wysong A
Dermatol Surg 2018 Oct;44(10):1247-1261. doi: 10.1097/DSS.0000000000001566. PMID: 29894433
Nonmelanoma skin cancer.
Dubas LE, Ingraffea A
Facial Plast Surg Clin North Am 2013 Feb;21(1):43-53. doi: 10.1016/j.fsc.2012.10.003. PMID: 23369588
Vulvar eccrine porocarcinoma.
Katsanis WA, Doering DL, Bosscher JR, O'Connor DM
Gynecol Oncol 1996 Sep;62(3):396-9. doi: 10.1006/gyno.1996.0255. PMID: 8812539
Epidermotropic eccrine porocarcinoma.
Landa NG, Winkelmann RK
J Am Acad Dermatol 1991 Jan;24(1):27-31. doi: 10.1016/0190-9622(91)70004-l. PMID: 1999525

Therapy

Squamoid Eccrine Ductal Carcinoma Displays Ultraviolet Mutations and Intermediate Gene Expression Relative to Squamous Cell Carcinoma, Microcystic Adnexal Carcinoma, and Porocarcinoma.
Harms PW, Runge M, Chan MP, Liu CJ, Qin Z, Worden F, Robinson DR, Chinnaiyan AM, Mclean SA, Harms KL, Fullen DR, Patel RM, Andea AA, Udager AM
Mod Pathol 2024 Nov;37(11):100592. Epub 2024 Aug 21 doi: 10.1016/j.modpat.2024.100592. PMID: 39154783Free PMC Article
Post-brachytherapy wound.
Gardner S
Br J Nurs 2017 Nov 8;26(Sup20a):S16-S17. doi: 10.12968/bjon.2017.26.Sup20a.S16. PMID: 29144783
Long-term survival after multidisciplinary management of a metastatic sarcomatoid porocarcinoma with repeated exeresis, radiotherapy, chemotherapy and cetuximab: case report and review of literature.
Ponzetti A, Ribero S, Caliendo V, Spadi R, Macripò G, Lista P
G Ital Dermatol Venereol 2017 Feb;152(1):66-70. Epub 2014 Sep 18 doi: 10.23736/S0392-0488.16.04778-7. PMID: 25236317
Chemotherapy of rare skin adnexal tumors: a review of literature.
De Iuliis F, Amoroso L, Taglieri L, Vendittozzi S, Blasi L, Salerno G, Lanza R, Scarpa S
Anticancer Res 2014 Oct;34(10):5263-8. PMID: 25275018
Eccrine porocarcinoma.
Brown CW Jr, Dy LC
Dermatol Ther 2008 Nov-Dec;21(6):433-8. doi: 10.1111/j.1529-8019.2008.00243.x. PMID: 19076620

Prognosis

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Eccrine porocarcinoma of the head and neck: Meta-analysis of 120 cases.
Le NS, Janik S, Liu DT, Grasl S, Faisal M, Pammer J, Schickinger-Fischer B, Hamzavi JS, Seemann R, Erovic BM
Head Neck 2020 Sep;42(9):2644-2659. Epub 2020 Apr 21 doi: 10.1002/hed.26178. PMID: 32314845
Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review.
Tidwell WJ, Mayer JE, Malone J, Schadt C, Brown T
Int J Dermatol 2015 Sep;54(9):1078-83. Epub 2015 Jul 23 doi: 10.1111/ijd.12997. PMID: 26205087
Eccrine Porocarcinoma Treated by Mohs Micrographic Surgery: Over 6-Year Follow-up of 12 Cases and Literature Review.
Xu YG, Aylward J, Longley BJ, Hinshaw MA, Snow SN
Dermatol Surg 2015 Jun;41(6):685-92. doi: 10.1097/DSS.0000000000000382. PMID: 25984905
Metastatic eccrine porocarcinoma.
Rehal B, Merin MR, Barr K
Cutis 2013 Aug;92(2):67-70. PMID: 24087778

Clinical prediction guides

Vulvar eccrine porocarcinoma: report of a case and literature review.
Val-Bernal JF, Hermana S
Rom J Morphol Embryol 2017;58(4):1611-1616. PMID: 29556664
Eccrine porocarcinoma shares dermoscopic characteristics with eccrine poroma: A report of three cases and review of the published work.
Edamitsu T, Minagawa A, Koga H, Uhara H, Okuyama R
J Dermatol 2016 Mar;43(3):332-5. Epub 2015 Sep 1 doi: 10.1111/1346-8138.13082. PMID: 26333057
Eccrine porocarcinoma: epidemiologic and histopathologic characteristics.
Riera-Leal L, Guevara-Gutiérrez E, Barrientos-García JG, Madrigal-Kasem R, Briseño-Rodríguez G, Tlacuilo-Parra A
Int J Dermatol 2015;54(5):580-6. Epub 2014 Dec 16 doi: 10.1111/ijd.12714. PMID: 25515648
Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases.
Robson A, Greene J, Ansari N, Kim B, Seed PT, McKee PH, Calonje E
Am J Surg Pathol 2001 Jun;25(6):710-20. doi: 10.1097/00000478-200106000-00002. PMID: 11395548
Eccrine porocarcinoma.
Akiyoshi E, Nogita T, Yamaguchi R, Toyoda H, Kawashima M, Hidano A
Dermatologica 1991;182(4):239-42. doi: 10.1159/000247804. PMID: 1653154

Recent systematic reviews

Porocarcinoma: Clinical and Histological Features, Immunohistochemistry and Outcomes: A Systematic Review.
Bienstman T, Güvenç C, Garmyn M
Int J Mol Sci 2024 May 25;25(11) doi: 10.3390/ijms25115760. PMID: 38891945Free PMC Article
The role of postoperative radiotherapy in eccrine porocarcinoma: a multidisciplinary systematic review.
Fionda B, Di Stefani A, Lancellotta V, Gentileschi S, Caretto AA, Casà C, Federico F, Rembielak A, Rossi E, Morganti AG, Schinzari G, Peris K, Tagliaferri L
Eur Rev Med Pharmacol Sci 2022 Mar;26(5):1695-1700. doi: 10.26355/eurrev_202203_28238. PMID: 35302218
A systematic review of periungual eccrine neoplasms.
Rao EM, Knackstedt TJ
Int J Dermatol 2022 Jul;61(7):812-820. Epub 2021 Sep 8 doi: 10.1111/ijd.15893. PMID: 34494261
Eccrine Porocarcinoma: New Insights and a Systematic Review of the Literature.
Nazemi A, Higgins S, Swift R, In G, Miller K, Wysong A
Dermatol Surg 2018 Oct;44(10):1247-1261. doi: 10.1097/DSS.0000000000001566. PMID: 29894433

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