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Resting heart rate(RHR)

MedGen UID:
369209
•Concept ID:
C1821417
•
Finding
Synonyms: Resting heart rate, variation in; RHR
SNOMED CT: Resting heart rate (444981005)
 
Gene (location): ADRB1 (10q25.3)
 
OMIM®: 607276

Professional guidelines

PubMed

Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis.
Kite C, Lahart IM, Afzal I, Broom DR, Randeva H, Kyrou I, Brown JE
Syst Rev 2019 Feb 12;8(1):51. doi: 10.1186/s13643-019-0962-3. PMID: 30755271Free PMC Article
Significance, prognostic value and management of heart rate in hypertension.
Courand PY, Lantelme P
Arch Cardiovasc Dis 2014 Jan;107(1):48-57. Epub 2014 Jan 16 doi: 10.1016/j.acvd.2013.11.003. PMID: 24439523
Atrial fibrillation: diagnosis and treatment.
Gutierrez C, Blanchard DG
Am Fam Physician 2011 Jan 1;83(1):61-8. PMID: 21888129

Recent clinical studies

Etiology

Resting heart rate, cognitive function, and inflammation in older adults: a population-based study.
Mao M, Liu R, Dong Y, Wang C, Ren Y, Tian N, Tang S, Hou T, Cong L, Wang Y, Du Y, Qiu C
Aging Clin Exp Res 2023 Nov;35(11):2821-2829. Epub 2023 Oct 29 doi: 10.1007/s40520-023-02576-8. PMID: 37898962Free PMC Article
Editorial commentary: Resting heart rate and outcomes: Risk marker or risk factor?
Dasa O, Ruzieh M
Trends Cardiovasc Med 2023 Nov;33(8):516-517. Epub 2022 Jun 3 doi: 10.1016/j.tcm.2022.05.011. PMID: 35667637
Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults.
Quer G, Gouda P, Galarnyk M, Topol EJ, Steinhubl SR
PLoS One 2020;15(2):e0227709. Epub 2020 Feb 5 doi: 10.1371/journal.pone.0227709. PMID: 32023264Free PMC Article
Resting heart rate and relation to disease and longevity: past, present and future.
Jensen MT
Scand J Clin Lab Invest 2019 Feb-Apr;79(1-2):108-116. Epub 2019 Feb 14 doi: 10.1080/00365513.2019.1566567. PMID: 30761923
Resting heart rate: risk indicator and emerging risk factor in cardiovascular disease.
Böhm M, Reil JC, Deedwania P, Kim JB, Borer JS
Am J Med 2015 Mar;128(3):219-28. Epub 2014 Oct 15 doi: 10.1016/j.amjmed.2014.09.016. PMID: 25447617

Diagnosis

Editorial commentary: Resting heart rate and outcomes: Risk marker or risk factor?
Dasa O, Ruzieh M
Trends Cardiovasc Med 2023 Nov;33(8):516-517. Epub 2022 Jun 3 doi: 10.1016/j.tcm.2022.05.011. PMID: 35667637
The respiratory modulation of interoception.
Molle L, Coste A
J Neurophysiol 2022 Apr 1;127(4):896-899. Epub 2022 Mar 16 doi: 10.1152/jn.00027.2022. PMID: 35294271
Inappropriate sinus tachycardia: a review.
Ali M, Haji AQ, Kichloo A, Grubb BP, Kanjwal K
Rev Cardiovasc Med 2021 Dec 22;22(4):1331-1339. doi: 10.31083/j.rcm2204139. PMID: 34957774
Resting heart rate and relation to disease and longevity: past, present and future.
Jensen MT
Scand J Clin Lab Invest 2019 Feb-Apr;79(1-2):108-116. Epub 2019 Feb 14 doi: 10.1080/00365513.2019.1566567. PMID: 30761923
Heart-rate recovery immediately after exercise as a predictor of mortality.
Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS
N Engl J Med 1999 Oct 28;341(18):1351-7. doi: 10.1056/NEJM199910283411804. PMID: 10536127

Therapy

Effect of Digoxin vs Bisoprolol for Heart Rate Control in Atrial Fibrillation on Patient-Reported Quality of Life: The RATE-AF Randomized Clinical Trial.
Kotecha D, Bunting KV, Gill SK, Mehta S, Stanbury M, Jones JC, Haynes S, Calvert MJ, Deeks JJ, Steeds RP, Strauss VY, Rahimi K, Camm AJ, Griffith M, Lip GYH, Townend JN, Kirchhof P; Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF) Team
JAMA 2020 Dec 22;324(24):2497-2508. doi: 10.1001/jama.2020.23138. PMID: 33351042Free PMC Article
Resting heart rate and relation to disease and longevity: past, present and future.
Jensen MT
Scand J Clin Lab Invest 2019 Feb-Apr;79(1-2):108-116. Epub 2019 Feb 14 doi: 10.1080/00365513.2019.1566567. PMID: 30761923
Isometric exercise training for blood pressure management: a systematic review and meta-analysis.
Carlson DJ, Dieberg G, Hess NC, Millar PJ, Smart NA
Mayo Clin Proc 2014 Mar;89(3):327-34. doi: 10.1016/j.mayocp.2013.10.030. PMID: 24582191
Lenient versus strict rate control in patients with atrial fibrillation.
Van Gelder IC, Groenveld HF, Crijns HJ, Tuininga YS, Tijssen JG, Alings AM, Hillege HL, Bergsma-Kadijk JA, Cornel JH, Kamp O, Tukkie R, Bosker HA, Van Veldhuisen DJ, Van den Berg MP; RACE II Investigators
N Engl J Med 2010 Apr 15;362(15):1363-73. Epub 2010 Mar 15 doi: 10.1056/NEJMoa1001337. PMID: 20231232
The Physical Activity Scale for the Elderly (PASE): development and evaluation.
Washburn RA, Smith KW, Jette AM, Janney CA
J Clin Epidemiol 1993 Feb;46(2):153-62. doi: 10.1016/0895-4356(93)90053-4. PMID: 8437031

Prognosis

Importance of resting heart rate.
Olshansky B, Ricci F, Fedorowski A
Trends Cardiovasc Med 2023 Nov;33(8):502-515. Epub 2022 May 25 doi: 10.1016/j.tcm.2022.05.006. PMID: 35623552
Ivabradine in Children With Dilated Cardiomyopathy and Symptomatic Chronic Heart Failure.
Bonnet D, Berger F, Jokinen E, Kantor PF, Daubeney PEF
J Am Coll Cardiol 2017 Sep 5;70(10):1262-1272. doi: 10.1016/j.jacc.2017.07.725. PMID: 28859790
Heart rate and cardiovascular protection.
Caetano J, Delgado Alves J
Eur J Intern Med 2015 May;26(4):217-22. Epub 2015 Feb 20 doi: 10.1016/j.ejim.2015.02.009. PMID: 25704330
Lenient versus strict rate control in patients with atrial fibrillation.
Van Gelder IC, Groenveld HF, Crijns HJ, Tuininga YS, Tijssen JG, Alings AM, Hillege HL, Bergsma-Kadijk JA, Cornel JH, Kamp O, Tukkie R, Bosker HA, Van Veldhuisen DJ, Van den Berg MP; RACE II Investigators
N Engl J Med 2010 Apr 15;362(15):1363-73. Epub 2010 Mar 15 doi: 10.1056/NEJMoa1001337. PMID: 20231232
Heart-rate recovery immediately after exercise as a predictor of mortality.
Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS
N Engl J Med 1999 Oct 28;341(18):1351-7. doi: 10.1056/NEJM199910283411804. PMID: 10536127

Clinical prediction guides

Importance of resting heart rate.
Olshansky B, Ricci F, Fedorowski A
Trends Cardiovasc Med 2023 Nov;33(8):502-515. Epub 2022 May 25 doi: 10.1016/j.tcm.2022.05.006. PMID: 35623552
Six-minute walk distance in healthy young adults.
Halliday SJ, Wang L, Yu C, Vickers BP, Newman JH, Fremont RD, Huerta LE, Brittain EL, Hemnes AR
Respir Med 2020 Apr-May;165:105933. Epub 2020 Mar 19 doi: 10.1016/j.rmed.2020.105933. PMID: 32308201Free PMC Article
Heart rate and cardiovascular protection.
Caetano J, Delgado Alves J
Eur J Intern Med 2015 May;26(4):217-22. Epub 2015 Feb 20 doi: 10.1016/j.ejim.2015.02.009. PMID: 25704330
Resting heart rate: risk indicator and emerging risk factor in cardiovascular disease.
Böhm M, Reil JC, Deedwania P, Kim JB, Borer JS
Am J Med 2015 Mar;128(3):219-28. Epub 2014 Oct 15 doi: 10.1016/j.amjmed.2014.09.016. PMID: 25447617
The Physical Activity Scale for the Elderly (PASE): development and evaluation.
Washburn RA, Smith KW, Jette AM, Janney CA
J Clin Epidemiol 1993 Feb;46(2):153-62. doi: 10.1016/0895-4356(93)90053-4. PMID: 8437031

Recent systematic reviews

Isometric Resistance Training to Manage Hypertension: Systematic Review and Meta-analysis.
Baffour-Awuah B, Pearson MJ, Dieberg G, Smart NA
Curr Hypertens Rep 2023 Apr;25(4):35-49. Epub 2023 Feb 28 doi: 10.1007/s11906-023-01232-w. PMID: 36853479Free PMC Article
Cardiovascular Effects of ADHD Therapies: JACC Review Topic of the Week.
Torres-Acosta N, O'Keefe JH, O'Keefe CL, Lavie CJ
J Am Coll Cardiol 2020 Aug 18;76(7):858-866. doi: 10.1016/j.jacc.2020.05.081. PMID: 32792083
Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis.
Kite C, Lahart IM, Afzal I, Broom DR, Randeva H, Kyrou I, Brown JE
Syst Rev 2019 Feb 12;8(1):51. doi: 10.1186/s13643-019-0962-3. PMID: 30755271Free PMC Article
Yoga, mindfulness-based stress reduction and stress-related physiological measures: A meta-analysis.
Pascoe MC, Thompson DR, Ski CF
Psychoneuroendocrinology 2017 Dec;86:152-168. Epub 2017 Aug 30 doi: 10.1016/j.psyneuen.2017.08.008. PMID: 28963884
Isometric exercise training for blood pressure management: a systematic review and meta-analysis.
Carlson DJ, Dieberg G, Hess NC, Millar PJ, Smart NA
Mayo Clin Proc 2014 Mar;89(3):327-34. doi: 10.1016/j.mayocp.2013.10.030. PMID: 24582191

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    • ClinVar
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      Clinical tests in GTR
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    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
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