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Susceptibility to severe cutaneous adverse reaction

MedGen UID:
326760
•Concept ID:
C1840548
•
Finding
Synonym: SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO
 
Genes (locations): HLA-A (6p22.1); HLA-B (6p21.33)
 
OMIM®: 608579

Professional guidelines

PubMed

Clinical presentation and management of atypical and recalcitrant acute generalized exanthematous pustulosis.
Hadavand MA, Kaffenberger B, Cartron AM, Trinidad JCL
J Am Acad Dermatol 2022 Sep;87(3):632-639. Epub 2020 Sep 11 doi: 10.1016/j.jaad.2020.09.024. PMID: 32926975
Adverse drug reactions in tuberculosis and management.
Prasad R, Singh A, Gupta N
Indian J Tuberc 2019 Oct;66(4):520-532. doi: 10.1016/j.ijtb.2019.11.005. PMID: 31813444
Pharmacogenetics of hypersensitivity drug reactions.
Negrini S, Becquemont L
Therapie 2017 Apr;72(2):231-243. Epub 2017 Jan 3 doi: 10.1016/j.therap.2016.12.009. PMID: 28162244

Recent clinical studies

Etiology

Clinical and pathogenic aspects of the severe cutaneous adverse reaction epidermal necrolysis (EN).
Kuijper EC, French LE, Tensen CP, Vermeer MH, Bouwes Bavinck JN
J Eur Acad Dermatol Venereol 2020 Sep;34(9):1957-1971. Epub 2020 May 15 doi: 10.1111/jdv.16339. PMID: 32415695Free PMC Article
Adverse drug reactions in tuberculosis and management.
Prasad R, Singh A, Gupta N
Indian J Tuberc 2019 Oct;66(4):520-532. doi: 10.1016/j.ijtb.2019.11.005. PMID: 31813444
Immunopathogenesis and risk factors for allopurinol severe cutaneous adverse reactions.
Wang CW, Dao RL, Chung WH
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):339-45. doi: 10.1097/ACI.0000000000000286. PMID: 27362322
Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury.
Kaniwa N, Saito Y
J Hum Genet 2013 Jun;58(6):317-26. Epub 2013 May 2 doi: 10.1038/jhg.2013.37. PMID: 23635947
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Diagnosis

Cytokines/Chemokines: Novel Biomarkers Associated with Severe Cutaneous Adverse Reactions.
Zhang X, Lu WS, Qin XM
J Interferon Cytokine Res 2020 Apr;40(4):172-181. Epub 2020 Mar 20 doi: 10.1089/jir.2019.0012. PMID: 32195616
Making a diagnosis in severe cutaneous drug hypersensitivity reactions.
Ardern-Jones MR, Mockenhaupt M
Curr Opin Allergy Clin Immunol 2019 Aug;19(4):283-293. doi: 10.1097/ACI.0000000000000546. PMID: 31247634
Adverse cutaneous drug eruptions: current understanding.
Hoetzenecker W, Nägeli M, Mehra ET, Jensen AN, Saulite I, Schmid-Grendelmeier P, Guenova E, Cozzio A, French LE
Semin Immunopathol 2016 Jan;38(1):75-86. Epub 2015 Nov 9 doi: 10.1007/s00281-015-0540-2. PMID: 26553194
DRESS syndrome.
Descamps V, Ranger-Rogez S
Joint Bone Spine 2014 Jan;81(1):15-21. Epub 2013 Jun 29 doi: 10.1016/j.jbspin.2013.05.002. PMID: 23816504
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Therapy

Adverse drug reactions in tuberculosis and management.
Prasad R, Singh A, Gupta N
Indian J Tuberc 2019 Oct;66(4):520-532. doi: 10.1016/j.ijtb.2019.11.005. PMID: 31813444
Pharmacogenetics of hypersensitivity drug reactions.
Negrini S, Becquemont L
Therapie 2017 Apr;72(2):231-243. Epub 2017 Jan 3 doi: 10.1016/j.therap.2016.12.009. PMID: 28162244
Drug-reaction eosinophilia and systemic symptoms and drug-induced hypersensitivity syndrome.
Fernando SL
Australas J Dermatol 2014 Feb;55(1):15-23. Epub 2013 Jul 19 doi: 10.1111/ajd.12085. PMID: 23866082
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article
Allopurinol in dermatology.
Tsai TF, Yeh TY
Am J Clin Dermatol 2010;11(4):225-32. doi: 10.2165/11533190-000000000-00000. PMID: 20509717

Prognosis

Pharmacogenetics of hypersensitivity drug reactions.
Negrini S, Becquemont L
Therapie 2017 Apr;72(2):231-243. Epub 2017 Jan 3 doi: 10.1016/j.therap.2016.12.009. PMID: 28162244
Immunopathogenesis and risk factors for allopurinol severe cutaneous adverse reactions.
Wang CW, Dao RL, Chung WH
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):339-45. doi: 10.1097/ACI.0000000000000286. PMID: 27362322
Adverse cutaneous drug eruptions: current understanding.
Hoetzenecker W, Nägeli M, Mehra ET, Jensen AN, Saulite I, Schmid-Grendelmeier P, Guenova E, Cozzio A, French LE
Semin Immunopathol 2016 Jan;38(1):75-86. Epub 2015 Nov 9 doi: 10.1007/s00281-015-0540-2. PMID: 26553194
DRESS syndrome.
Descamps V, Ranger-Rogez S
Joint Bone Spine 2014 Jan;81(1):15-21. Epub 2013 Jun 29 doi: 10.1016/j.jbspin.2013.05.002. PMID: 23816504
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Clinical prediction guides

Adverse drug reactions in tuberculosis and management.
Prasad R, Singh A, Gupta N
Indian J Tuberc 2019 Oct;66(4):520-532. doi: 10.1016/j.ijtb.2019.11.005. PMID: 31813444
HLA-associated drug hypersensitivity and the prediction of adverse drug reactions.
Negrini S, Becquemont L
Pharmacogenomics 2017 Oct;18(15):1441-1457. Epub 2017 Oct 11 doi: 10.2217/pgs-2017-0090. PMID: 29017379
Pharmacogenetics of hypersensitivity drug reactions.
Negrini S, Becquemont L
Therapie 2017 Apr;72(2):231-243. Epub 2017 Jan 3 doi: 10.1016/j.therap.2016.12.009. PMID: 28162244
Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury.
Kaniwa N, Saito Y
J Hum Genet 2013 Jun;58(6):317-26. Epub 2013 May 2 doi: 10.1038/jhg.2013.37. PMID: 23635947
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Recent systematic reviews

Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis.
Alfares I, Javaid MS, Chen Z, Anderson A, Antonic-Baker A, Kwan P
CNS Drugs 2021 Feb;35(2):161-176. Epub 2021 Feb 12 doi: 10.1007/s40263-021-00794-0. PMID: 33580477
HLA genotypes and cold medicine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications: a systematic review and meta-analysis.
Tangamornsuksan W, Chanprasert S, Nadee P, Rungruang S, Meesilsat N, Ueta M, Lohitnavy M
Sci Rep 2020 Jun 29;10(1):10589. doi: 10.1038/s41598-020-67610-5. PMID: 32601360Free PMC Article
HLA alleles and hypersensitivity to carbamazepine: an updated systematic review with meta-analysis.
Grover S, Kukreti R
Pharmacogenet Genomics 2014 Feb;24(2):94-112. doi: 10.1097/FPC.0000000000000021. PMID: 24336023

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