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Microvascular complications of diabetes, susceptibility to, 4(MVCD4)

MedGen UID:
382527
•Concept ID:
C2675112
•
Finding
Synonym: Microvascular complications of diabetes 4
 
Gene (location): IL1RN (2q14.1)
 
Monarch Initiative: MONDO:0012966
OMIM®: 612628

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the IL1RN gene. [from MONDO]

Professional guidelines

PubMed

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Report of the Committee on the classification and diagnostic criteria of diabetes mellitus.
Kuzuya T, Nakagawa S, Satoh J, Kanazawa Y, Iwamoto Y, Kobayashi M, Nanjo K, Sasaki A, Seino Y, Ito C, Shima K, Nonaka K, Kadowaki T; Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus
Diabetes Res Clin Pract 2002 Jan;55(1):65-85. doi: 10.1016/s0168-8227(01)00365-5. PMID: 11755481

Recent clinical studies

Etiology

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta-analysis.
Fu H, Guo C, Zhang J, Xu L, Jiang S, Guo S, Sheng Q, Zhao J, Liao L
IUBMB Life 2023 Jul;75(7):624-642. Epub 2023 Mar 1 doi: 10.1002/iub.2711. PMID: 36856001
MicroRNA-423 may regulate diabetic vasculopathy.
Blum A, Meerson A, Rohana H, Jabaly H, Nahul N, Celesh D, Romanenko O, Tamir S
Clin Exp Med 2019 Nov;19(4):469-477. Epub 2019 Aug 17 doi: 10.1007/s10238-019-00573-8. PMID: 31422516
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article

Diagnosis

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.
Mansour A, Mousa M, Abdelmannan D, Tay G, Hassoun A, Alsafar H
Front Endocrinol (Lausanne) 2023;14:1143067. Epub 2023 Mar 23 doi: 10.3389/fendo.2023.1143067. PMID: 37033211Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Reactive oxygen species signalling in the diabetic heart: emerging prospect for therapeutic targeting.
Wilson AJ, Gill EK, Abudalo RA, Edgar KS, Watson CJ, Grieve DJ
Heart 2018 Feb;104(4):293-299. Epub 2017 Sep 27 doi: 10.1136/heartjnl-2017-311448. PMID: 28954833
MicroRNAs and diabetic complications.
Natarajan R, Putta S, Kato M
J Cardiovasc Transl Res 2012 Aug;5(4):413-22. Epub 2012 May 3 doi: 10.1007/s12265-012-9368-5. PMID: 22552970Free PMC Article

Therapy

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta-analysis.
Fu H, Guo C, Zhang J, Xu L, Jiang S, Guo S, Sheng Q, Zhao J, Liao L
IUBMB Life 2023 Jul;75(7):624-642. Epub 2023 Mar 1 doi: 10.1002/iub.2711. PMID: 36856001
Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring.
Hermans MP, Ahn SA, Rousseau MF
J Diabetes 2019 Apr;11(4):301-308. Epub 2018 Sep 23 doi: 10.1111/1753-0407.12840. PMID: 30105804
Ranolazine reduces repolarization heterogeneity in symptomatic patients with diabetes and non-flow-limiting coronary artery stenosis.
Evaristo E, Stocco FG, Shah NR, Cheezum MK, Hainer J, Foster C, Nearing BD, Di Carli M, Verrier RL
Ann Noninvasive Electrocardiol 2018 Jan;23(1) Epub 2017 Jun 27 doi: 10.1111/anec.12480. PMID: 28653394Free PMC Article
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article

Prognosis

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Recent advances in exploring the genetic susceptibility to diabetic neuropathy.
Politi C, Ciccacci C, D'Amato C, Novelli G, Borgiani P, Spallone V
Diabetes Res Clin Pract 2016 Oct;120:198-208. Epub 2016 Aug 26 doi: 10.1016/j.diabres.2016.08.006. PMID: 27596057
Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients.
Durlach V, Durlach A, Movesayan I, Socquard E, Zellner C, Clavel C, Nazeyrollas P, Malloy MJ, Pullinger CR, Kane JP, Ducasse A, Aouizerat BE
Diabetes Metab 2011 Feb;37(1):64-71. Epub 2010 Dec 9 doi: 10.1016/j.diabet.2010.07.010. PMID: 21145773
Consequences of pancreas transplantation.
Larsen JL, Stratta RJ
J Investig Med 1994 Dec;42(4):622-31. PMID: 8521025

Clinical prediction guides

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Recent advances in exploring the genetic susceptibility to diabetic neuropathy.
Politi C, Ciccacci C, D'Amato C, Novelli G, Borgiani P, Spallone V
Diabetes Res Clin Pract 2016 Oct;120:198-208. Epub 2016 Aug 26 doi: 10.1016/j.diabres.2016.08.006. PMID: 27596057
Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes: associations with microvascular disease complications in the DCCT/EDIC cohort.
Klein RL, McHenry MB, Lok KH, Hunter SJ, Le NA, Jenkins AJ, Zheng D, Semler A, Page G, Brown WV, Lyons TJ, Garvey WT; DCCT/EDIC Research Group
J Diabetes Complications 2005 Jan-Feb;19(1):18-25. doi: 10.1016/j.jdiacomp.2004.04.005. PMID: 15642486
Consequences of pancreas transplantation.
Larsen JL, Stratta RJ
J Investig Med 1994 Dec;42(4):622-31. PMID: 8521025

Recent systematic reviews

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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