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Major affective disorder 7(MAFD7)

MedGen UID:
438008
Concept ID:
C2700438
Mental or Behavioral Dysfunction
Synonym: MAFD7
 
Gene (location): XBP1 (22q12.1)
 
Monarch Initiative: MONDO:0012881
OMIM®: 612371

Definition

Bipolar disorder is classified into several types based on the mood changes that occur. Bipolar I involves manic episodes, which can be accompanied by psychotic symptoms, and hypomanic or depressive episodes. Bipolar II involves hypomanic episodes and depressive episodes. Cyclothymic disorder involves hypomanic episodes and depressive episodes that are typically less severe than those in bipolar I or bipolar II.

Manic and depressive episodes can include psychotic symptoms, such as false perceptions (hallucinations) or strongly held false beliefs (delusions). Mixed episodes, which have features of manic and depressive episodes at the same time, also occur in some affected individuals.

Bipolar disorder often occurs with other mental health conditions, including anxiety disorders (such as panic attacks), behavioral disorders (such as attention-deficit/hyperactivity disorder), and substance abuse.

Depressive episodes are marked by low energy and activity, a feeling of hopelessness, and an inability to perform everyday tasks. People with bipolar disorder often have repeated thoughts of death and suicide, and they have a much greater risk of dying by suicide than the general population.

Manic episodes are characterized by increased energy and activity, irritability, restlessness, an inability to sleep, and reckless behavior. Some people with bipolar disorder experience hypomanic episodes, which are similar to but less extreme than manic episodes.

People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes. These episodes can last from hours to weeks, and many people have no symptoms between episodes.

Bipolar disorder is a mental health condition that causes extreme shifts in mood, energy, and behavior. This disorder most often appears in late adolescence or early adulthood, although symptoms can begin at any time of life. [from MedlinePlus Genetics]

Professional guidelines

PubMed

Kverno KS, Mangano E
J Psychosoc Nurs Ment Health Serv 2021 Sep;59(9):7-11. Epub 2021 Sep 1 doi: 10.3928/02793695-20210816-01. PMID: 34459676
Cuijpers P, Quero S, Dowrick C, Arroll B
Curr Psychiatry Rep 2019 Nov 23;21(12):129. doi: 10.1007/s11920-019-1117-x. PMID: 31760505Free PMC Article
Kooij JJS, Bijlenga D, Salerno L, Jaeschke R, Bitter I, Balázs J, Thome J, Dom G, Kasper S, Nunes Filipe C, Stes S, Mohr P, Leppämäki S, Casas M, Bobes J, Mccarthy JM, Richarte V, Kjems Philipsen A, Pehlivanidis A, Niemela A, Styr B, Semerci B, Bolea-Alamanac B, Edvinsson D, Baeyens D, Wynchank D, Sobanski E, Philipsen A, McNicholas F, Caci H, Mihailescu I, Manor I, Dobrescu I, Saito T, Krause J, Fayyad J, Ramos-Quiroga JA, Foeken K, Rad F, Adamou M, Ohlmeier M, Fitzgerald M, Gill M, Lensing M, Motavalli Mukaddes N, Brudkiewicz P, Gustafsson P, Tani P, Oswald P, Carpentier PJ, De Rossi P, Delorme R, Markovska Simoska S, Pallanti S, Young S, Bejerot S, Lehtonen T, Kustow J, Müller-Sedgwick U, Hirvikoski T, Pironti V, Ginsberg Y, Félegyházy Z, Garcia-Portilla MP, Asherson P
Eur Psychiatry 2019 Feb;56:14-34. Epub 2018 Nov 16 doi: 10.1016/j.eurpsy.2018.11.001. PMID: 30453134

Curated

UK NICE Clinical Guideline CG185, Bipolar disorder: assessment and management, 2023

Recent clinical studies

Etiology

Tomasik J, Harrison SJ, Rustogi N, Olmert T, Barton-Owen G, Han SYS, Cooper JD, Eljasz P, Farrag LP, Friend LV, Bell E, Cowell D, Bahn S
JAMA Psychiatry 2024 Jan 1;81(1):101-106. doi: 10.1001/jamapsychiatry.2023.4096. PMID: 37878349Free PMC Article
Nikolova VL, Cleare AJ, Young AH, Stone JM
JAMA Psychiatry 2023 Aug 1;80(8):842-847. doi: 10.1001/jamapsychiatry.2023.1817. PMID: 37314797Free PMC Article
Kuś A, Kjaergaard AD, Marouli E, Del Greco M F, Sterenborg RBTM, Chaker L, Peeters RP, Bednarczuk T, Åsvold BO, Burgess S, Deloukas P, Teumer A, Ellervik C, Medici M
Thyroid 2021 Aug;31(8):1171-1181. Epub 2021 May 26 doi: 10.1089/thy.2020.0884. PMID: 33899528Free PMC Article
Sandstrom A, Perroud N, Alda M, Uher R, Pavlova B
Acta Psychiatr Scand 2021 May;143(5):380-391. Epub 2021 Feb 15 doi: 10.1111/acps.13283. PMID: 33528847
Kessler RC, Petukhova M, Sampson NA, Zaslavsky AM, Wittchen H -U
Int J Methods Psychiatr Res 2012 Sep;21(3):169-84. Epub 2012 Aug 1 doi: 10.1002/mpr.1359. PMID: 22865617Free PMC Article

Diagnosis

Tomasik J, Harrison SJ, Rustogi N, Olmert T, Barton-Owen G, Han SYS, Cooper JD, Eljasz P, Farrag LP, Friend LV, Bell E, Cowell D, Bahn S
JAMA Psychiatry 2024 Jan 1;81(1):101-106. doi: 10.1001/jamapsychiatry.2023.4096. PMID: 37878349Free PMC Article
Leichsenring F, Heim N, Leweke F, Spitzer C, Steinert C, Kernberg OF
JAMA 2023 Feb 28;329(8):670-679. doi: 10.1001/jama.2023.0589. PMID: 36853245
Sandstrom A, Perroud N, Alda M, Uher R, Pavlova B
Acta Psychiatr Scand 2021 May;143(5):380-391. Epub 2021 Feb 15 doi: 10.1111/acps.13283. PMID: 33528847
Kessler RC, Petukhova M, Sampson NA, Zaslavsky AM, Wittchen H -U
Int J Methods Psychiatr Res 2012 Sep;21(3):169-84. Epub 2012 Aug 1 doi: 10.1002/mpr.1359. PMID: 22865617Free PMC Article
Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE
Arch Gen Psychiatry 2005 Jun;62(6):617-27. doi: 10.1001/archpsyc.62.6.617. PMID: 15939839Free PMC Article

Therapy

Neuteboom D, Zantvoord JB, Goya-Maldonado R, Wilkening J, Dols A, van Exel E, Lok A, de Haan L, Scheepstra KWF
Psychiatry Res 2023 Sep;327:115429. Epub 2023 Aug 21 doi: 10.1016/j.psychres.2023.115429. PMID: 37625365
Nikolova VL, Cleare AJ, Young AH, Stone JM
JAMA Psychiatry 2023 Aug 1;80(8):842-847. doi: 10.1001/jamapsychiatry.2023.1817. PMID: 37314797Free PMC Article
Sandstrom A, Perroud N, Alda M, Uher R, Pavlova B
Acta Psychiatr Scand 2021 May;143(5):380-391. Epub 2021 Feb 15 doi: 10.1111/acps.13283. PMID: 33528847
Kaur Gill A, Bansal Y, Bhandari R, Kaur S, Kaur J, Singh R, Kuhad A, Kuhad A
Drugs Today (Barc) 2019 Jul;55(7):423-437. doi: 10.1358/dot.2019.55.7.2958474. PMID: 31347611
Sinyor M, Schaffer A, Levitt A
Can J Psychiatry 2010 Mar;55(3):126-35. doi: 10.1177/070674371005500303. PMID: 20370962

Prognosis

Schulte EC, Kondofersky I, Budde M, Papiol S, Senner F, Schaupp SK, Reich-Erkelenz D, Klöhn-Saghatolislam F, Kalman JL, Gade K, Hake M, Comes AL, Anderson-Schmidt H, Adorjan K, Juckel G, Schmauß M, Zimmermann J, Reimer J, Wiltfang J, Reininghaus EZ, Anghelescu IG, Konrad C, Figge C, von Hagen M, Jäger M, Dietrich DE, Spitzer C, Witt SH, Forstner AJ, Rietschel M, Nöthen MM, Falkai P, Heilbronner U, Mueller NS, Schulze TG
Schizophr Res 2022 Jun;244:29-38. Epub 2022 May 11 doi: 10.1016/j.schres.2022.05.001. PMID: 35567871
Kuś A, Kjaergaard AD, Marouli E, Del Greco M F, Sterenborg RBTM, Chaker L, Peeters RP, Bednarczuk T, Åsvold BO, Burgess S, Deloukas P, Teumer A, Ellervik C, Medici M
Thyroid 2021 Aug;31(8):1171-1181. Epub 2021 May 26 doi: 10.1089/thy.2020.0884. PMID: 33899528Free PMC Article
Schramm E, Klein DN, Elsaesser M, Furukawa TA, Domschke K
Lancet Psychiatry 2020 Sep;7(9):801-812. doi: 10.1016/S2215-0366(20)30099-7. PMID: 32828168
Worley LLM, Wise-Ehlers A
Obstet Gynecol Clin North Am 2020 Jun;47(2):333-340. doi: 10.1016/j.ogc.2020.02.009. PMID: 32451021
Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T
Obstet Gynecol 2005 Nov;106(5 Pt 1):1071-83. doi: 10.1097/01.AOG.0000183597.31630.db. PMID: 16260528

Clinical prediction guides

Tomasik J, Harrison SJ, Rustogi N, Olmert T, Barton-Owen G, Han SYS, Cooper JD, Eljasz P, Farrag LP, Friend LV, Bell E, Cowell D, Bahn S
JAMA Psychiatry 2024 Jan 1;81(1):101-106. doi: 10.1001/jamapsychiatry.2023.4096. PMID: 37878349Free PMC Article
Nikolova VL, Cleare AJ, Young AH, Stone JM
JAMA Psychiatry 2023 Aug 1;80(8):842-847. doi: 10.1001/jamapsychiatry.2023.1817. PMID: 37314797Free PMC Article
Leichsenring F, Heim N, Leweke F, Spitzer C, Steinert C, Kernberg OF
JAMA 2023 Feb 28;329(8):670-679. doi: 10.1001/jama.2023.0589. PMID: 36853245
Henter ID, Park LT, Zarate CA Jr
CNS Drugs 2021 May;35(5):527-543. Epub 2021 Apr 26 doi: 10.1007/s40263-021-00816-x. PMID: 33904154Free PMC Article
Kuś A, Kjaergaard AD, Marouli E, Del Greco M F, Sterenborg RBTM, Chaker L, Peeters RP, Bednarczuk T, Åsvold BO, Burgess S, Deloukas P, Teumer A, Ellervik C, Medici M
Thyroid 2021 Aug;31(8):1171-1181. Epub 2021 May 26 doi: 10.1089/thy.2020.0884. PMID: 33899528Free PMC Article

Recent systematic reviews

Yildiz A, Siafis S, Mavridis D, Vieta E, Leucht S
Lancet Psychiatry 2023 Sep;10(9):693-705. doi: 10.1016/S2215-0366(23)00199-2. PMID: 37595997
Pearce M, Garcia L, Abbas A, Strain T, Schuch FB, Golubic R, Kelly P, Khan S, Utukuri M, Laird Y, Mok A, Smith A, Tainio M, Brage S, Woodcock J
JAMA Psychiatry 2022 Jun 1;79(6):550-559. doi: 10.1001/jamapsychiatry.2022.0609. PMID: 35416941Free PMC Article
Bahji A, Vazquez GH, Zarate CA Jr
J Affect Disord 2021 Jan 1;278:542-555. Epub 2020 Sep 23 doi: 10.1016/j.jad.2020.09.071. PMID: 33022440Free PMC Article
Gobbi G, Atkin T, Zytynski T, Wang S, Askari S, Boruff J, Ware M, Marmorstein N, Cipriani A, Dendukuri N, Mayo N
JAMA Psychiatry 2019 Apr 1;76(4):426-434. doi: 10.1001/jamapsychiatry.2018.4500. PMID: 30758486Free PMC Article
Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T
Obstet Gynecol 2005 Nov;106(5 Pt 1):1071-83. doi: 10.1097/01.AOG.0000183597.31630.db. PMID: 16260528

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Clinical Guideline CG185, Bipolar disorder: assessment and management, 2023

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