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Renal hypomagnesemia 6(HOMG6)

MedGen UID:
462645
•Concept ID:
C3151295
•
Disease or Syndrome
Synonyms: HOMG6; HYPOMAGNESEMIA 6, RENAL
 
Gene (location): CNNM2 (10q24.32)
 
Monarch Initiative: MONDO:0013480
OMIM®: 613882

Clinical features

From HPO
Impaired renal tubular reabsorption of magnesium
MedGen UID:
1778245
•Concept ID:
C5539797
•
Finding
Decreased renal tubular reabsorption of magnesium.
See: Feature record | Search on this feature
Vertigo
MedGen UID:
53006
•Concept ID:
C0042571
•
Sign or Symptom
An abnormal sensation of spinning while the body is actually stationary.
See: Feature record | Search on this feature
Headache
MedGen UID:
9149
•Concept ID:
C0018681
•
Sign or Symptom
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.
See: Feature record | Search on this feature
Muscle weakness
MedGen UID:
57735
•Concept ID:
C0151786
•
Finding
Reduced strength of muscles.
See: Feature record | Search on this feature
Hypomagnesemia
MedGen UID:
57481
•Concept ID:
C0151723
•
Disease or Syndrome
An abnormally decreased magnesium concentration in the blood.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Wang B, Bonkovsky HL, Lim JK, Balwani M
Gastroenterology 2023 Mar;164(3):484-491. Epub 2023 Jan 13 doi: 10.1053/j.gastro.2022.11.034. PMID: 36642627Free PMC Article
Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: presentations, causes, and treatment strategies.
Hamed SA
Expert Rev Clin Pharmacol 2019 Jan;12(1):61-90. Epub 2019 Jan 11 doi: 10.1080/17512433.2019.1555468. PMID: 30501441
Protocol for the detection and nutritional management of high-output stomas.
Arenas Villafranca JJ, López-Rodríguez C, Abilés J, Rivera R, Gándara Adán N, Utrilla Navarro P
Nutr J 2015 May 9;14:45. doi: 10.1186/s12937-015-0034-z. PMID: 25956387Free PMC Article

Recent clinical studies

Etiology

AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Wang B, Bonkovsky HL, Lim JK, Balwani M
Gastroenterology 2023 Mar;164(3):484-491. Epub 2023 Jan 13 doi: 10.1053/j.gastro.2022.11.034. PMID: 36642627Free PMC Article
Serum Magnesium after Kidney Transplantation: A Systematic Review.
Garnier AS, Duveau A, Planchais M, Subra JF, Sayegh J, Augusto JF
Nutrients 2018 Jun 6;10(6) doi: 10.3390/nu10060729. PMID: 29882768Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial.
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544
Protocol for the detection and nutritional management of high-output stomas.
Arenas Villafranca JJ, López-Rodríguez C, Abilés J, Rivera R, Gándara Adán N, Utrilla Navarro P
Nutr J 2015 May 9;14:45. doi: 10.1186/s12937-015-0034-z. PMID: 25956387Free PMC Article

Diagnosis

The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury.
Mapuskar KA, Pulliam CF, Tomanek-Chalkley A, Rastogi P, Wen H, Dayal S, Griffin BR, Zepeda-Orozco D, Sindler AL, Anderson CM, Beardsley R, Kennedy EP, Spitz DR, Allen BG
Redox Biol 2024 Apr;70:103022. Epub 2024 Jan 1 doi: 10.1016/j.redox.2023.103022. PMID: 38215546Free PMC Article
AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Wang B, Bonkovsky HL, Lim JK, Balwani M
Gastroenterology 2023 Mar;164(3):484-491. Epub 2023 Jan 13 doi: 10.1053/j.gastro.2022.11.034. PMID: 36642627Free PMC Article
Pathophysiologic approach in genetic hypokalemia: An update.
Blanchard A
Ann Endocrinol (Paris) 2023 Apr;84(2):298-307. Epub 2023 Jan 10 doi: 10.1016/j.ando.2022.11.005. PMID: 36639120
Diagnostic strategy for inherited hypomagnesemia.
Horinouchi T, Nozu K, Kamiyoshi N, Kamei K, Togawa H, Shima Y, Urahama Y, Yamamura T, Minamikawa S, Nakanishi K, Fujimura J, Morioka I, Ninchoji T, Kaito H, Nakanishi K, Iijima K
Clin Exp Nephrol 2017 Dec;21(6):1003-1010. Epub 2017 Mar 1 doi: 10.1007/s10157-017-1396-7. PMID: 28251383
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118

Therapy

AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Wang B, Bonkovsky HL, Lim JK, Balwani M
Gastroenterology 2023 Mar;164(3):484-491. Epub 2023 Jan 13 doi: 10.1053/j.gastro.2022.11.034. PMID: 36642627Free PMC Article
Serum Magnesium after Kidney Transplantation: A Systematic Review.
Garnier AS, Duveau A, Planchais M, Subra JF, Sayegh J, Augusto JF
Nutrients 2018 Jun 6;10(6) doi: 10.3390/nu10060729. PMID: 29882768Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial.
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544
Viomycin-induced electrolyte abnormalities.
Schwartz JS, Kempa JS, Vasilomanolakis EC, Szidon JP, Coe FL, Jao W
Respiration 1980;40(5):284-92. doi: 10.1159/000194291. PMID: 6262892

Prognosis

Impact of Serum Magnesium Levels on Kidney and Cardiovascular Prognosis and Mortality in CKD Patients.
Galán Carrillo I, Vega A, Goicoechea M, Shabaka A, Gatius S, Abad S, López-Gómez JM
J Ren Nutr 2021 Sep;31(5):494-502. Epub 2020 Dec 9 doi: 10.1053/j.jrn.2020.09.004. PMID: 33309408
Hypomagnesemia During Teriparatide Treatment in Osteoporosis: Incidence and Determinants.
Bégin MJ, Ste-Marie LG, Coupal L, Ethier J, Räkel A
J Bone Miner Res 2018 Aug;33(8):1444-1449. Epub 2018 May 17 doi: 10.1002/jbmr.3438. PMID: 29637622
Hypocalcaemia of malignancy.
Schattner A, Dubin I, Huber R, Gelber M
Neth J Med 2016 Jul;74(6):231-9. PMID: 27571720
Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial.
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544
Electrolyte disturbances and acute kidney injury in patients with cancer.
Lameire N, Van Biesen W, Vanholder R
Semin Nephrol 2010 Nov;30(6):534-47. doi: 10.1016/j.semnephrol.2010.09.002. PMID: 21146119

Clinical prediction guides

Electrolyte disorders in stable renal allograft recipients.
Beilhack G, Lindner G, Funk GC, Monteforte R, Schwarz C
Swiss Med Wkly 2020 Oct 19;150:w20366. Epub 2020 Nov 12 doi: 10.4414/smw.2020.20366. PMID: 33181857
Extreme hypomagnesemia: characteristics of 119 consecutive inpatients.
Cheminet G, Clain G, Jannot AS, Ranque B, Passeron A, Michon A, De Luna G, Diehl JL, Oudard S, Cellier C, Karras A, Vedié B, Prot-Bertoye C, Pouchot J, Arlet JB
Intern Emerg Med 2018 Dec;13(8):1201-1209. Epub 2018 Jun 27 doi: 10.1007/s11739-018-1898-7. PMID: 29951810
Hypomagnesemia During Teriparatide Treatment in Osteoporosis: Incidence and Determinants.
Bégin MJ, Ste-Marie LG, Coupal L, Ethier J, Räkel A
J Bone Miner Res 2018 Aug;33(8):1444-1449. Epub 2018 May 17 doi: 10.1002/jbmr.3438. PMID: 29637622
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Protocol for the detection and nutritional management of high-output stomas.
Arenas Villafranca JJ, López-Rodríguez C, Abilés J, Rivera R, Gándara Adán N, Utrilla Navarro P
Nutr J 2015 May 9;14:45. doi: 10.1186/s12937-015-0034-z. PMID: 25956387Free PMC Article

Recent systematic reviews

Early and late adverse renal effects after potentially nephrotoxic treatment for childhood cancer.
Kooijmans EC, Bökenkamp A, Tjahjadi NS, Tettero JM, van Dulmen-den Broeder E, van der Pal HJ, Veening MA
Cochrane Database Syst Rev 2019 Mar 11;3(3):CD008944. doi: 10.1002/14651858.CD008944.pub3. PMID: 30855726Free PMC Article
Serum Magnesium after Kidney Transplantation: A Systematic Review.
Garnier AS, Duveau A, Planchais M, Subra JF, Sayegh J, Augusto JF
Nutrients 2018 Jun 6;10(6) doi: 10.3390/nu10060729. PMID: 29882768Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Hypomagnesemia and mortality in patients admitted to intensive care unit: a systematic review and meta-analysis.
Upala S, Jaruvongvanich V, Wijarnpreecha K, Sanguankeo A
QJM 2016 Jul;109(7):453-459. Epub 2016 Mar 24 doi: 10.1093/qjmed/hcw048. PMID: 27016536
Early and late renal adverse effects after potentially nephrotoxic treatment for childhood cancer.
Knijnenburg SL, Mulder RL, Schouten-Van Meeteren AY, Bökenkamp A, Blufpand H, van Dulmen-den Broeder E, Veening MA, Kremer LC, Jaspers MW
Cochrane Database Syst Rev 2013 Oct 8;(10):CD008944. doi: 10.1002/14651858.CD008944.pub2. PMID: 24101439

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