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Accelerated tumor formation, susceptibility to(ACTFS)

MedGen UID:
482320
Concept ID:
C3280690
Finding
Synonym: ACTFS
 
Gene (location): MDM2 (12q15)
 
OMIM®: 614401

Professional guidelines

PubMed

Xu C, Zhang L, Xu S, Wang Z, Han Q, Lv Y, Wang X, Zhang X, Zhang Q, Zhang Y, He S, Yuan Q, Bian Y, Li C, Wang J, Xu F, Cao Y, Pang J, Chen Y
Cell Mol Immunol 2024 May;21(5):510-526. Epub 2024 Mar 12 doi: 10.1038/s41423-024-01146-w. PMID: 38472357Free PMC Article
Wang Y, Wang C, Guan X, Ma Y, Zhang S, Li F, Yin Y, Sun Z, Chen X, Yin H
Adv Sci (Weinh) 2023 Dec;10(36):e2303812. Epub 2023 Nov 16 doi: 10.1002/advs.202303812. PMID: 37973560Free PMC Article
Eksteen B
Clin Liver Dis 2016 Feb;20(1):1-14. Epub 2015 Sep 26 doi: 10.1016/j.cld.2015.08.012. PMID: 26593287

Recent clinical studies

Etiology

Zhao R, Yang J, Zhai Y, Zhang H, Zhou Y, Hong L, Yuan D, Xia R, Liu Y, Pan J, Shafi S, Shi G, Zhang R, Luo D, Yuan J, Pan D, Peng C, Li S, Sun M
Nat Immunol 2024 Sep;25(9):1565-1579. Epub 2024 Aug 5 doi: 10.1038/s41590-024-01921-x. PMID: 39103576Free PMC Article
He F, Zhang P, Liu J, Wang R, Kaufman RJ, Yaden BC, Karin M
J Hepatol 2023 Aug;79(2):362-377. Epub 2023 Mar 28 doi: 10.1016/j.jhep.2023.03.016. PMID: 36996941Free PMC Article
Qian Y, Li Y, Li R, Yang T, Jia R, Ge YZ
J Cell Mol Med 2021 Nov;25(22):10349-10361. Epub 2021 Oct 26 doi: 10.1111/jcmm.16996. PMID: 34697887Free PMC Article
Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ, Kazmi N, Robinson TM, Albanes D, Aleksandrova K, Berndt SI, Timothy Bishop D, Brenner H, Buchanan DD, Bueno-de-Mesquita B, Campbell PT, Castellví-Bel S, Chan AT, Chang-Claude J, Ellingjord-Dale M, Figueiredo JC, Gallinger SJ, Giles GG, Giovannucci E, Gruber SB, Gsur A, Hampe J, Hampel H, Harlid S, Harrison TA, Hoffmeister M, Hopper JL, Hsu L, María Huerta J, Huyghe JR, Jenkins MA, Keku TO, Kühn T, La Vecchia C, Le Marchand L, Li CI, Li L, Lindblom A, Lindor NM, Lynch B, Markowitz SD, Masala G, May AM, Milne R, Monninkhof E, Moreno L, Moreno V, Newcomb PA, Offit K, Perduca V, Pharoah PDP, Platz EA, Potter JD, Rennert G, Riboli E, Sánchez MJ, Schmit SL, Schoen RE, Severi G, Sieri S, Slattery ML, Song M, Tangen CM, Thibodeau SN, Travis RC, Trichopoulou A, Ulrich CM, van Duijnhoven FJB, Van Guelpen B, Vodicka P, White E, Wolk A, Woods MO, Wu AH, Peters U, Gunter MJ, Murphy N
Nat Commun 2020 Jan 30;11(1):597. doi: 10.1038/s41467-020-14389-8. PMID: 32001714Free PMC Article
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487

Diagnosis

Wei H, Li W, Zeng L, Ding N, Li K, Yu H, Jiang F, Yin H, Xia Y, Deng C, Cai N, Chen X, Gu L, Chen H, Zhang F, He Y, Li J, Zhang C
Mol Cancer 2024 Jun 7;23(1):124. doi: 10.1186/s12943-024-02016-9. PMID: 38849840Free PMC Article
Wang Y, Wang C, Guan X, Ma Y, Zhang S, Li F, Yin Y, Sun Z, Chen X, Yin H
Adv Sci (Weinh) 2023 Dec;10(36):e2303812. Epub 2023 Nov 16 doi: 10.1002/advs.202303812. PMID: 37973560Free PMC Article
Qian Y, Li Y, Li R, Yang T, Jia R, Ge YZ
J Cell Mol Med 2021 Nov;25(22):10349-10361. Epub 2021 Oct 26 doi: 10.1111/jcmm.16996. PMID: 34697887Free PMC Article
Chen L, Qin D, Guo X, Wang Q, Li J
Front Immunol 2021;12:593255. Epub 2021 Feb 23 doi: 10.3389/fimmu.2021.593255. PMID: 33708196Free PMC Article
Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ, Kazmi N, Robinson TM, Albanes D, Aleksandrova K, Berndt SI, Timothy Bishop D, Brenner H, Buchanan DD, Bueno-de-Mesquita B, Campbell PT, Castellví-Bel S, Chan AT, Chang-Claude J, Ellingjord-Dale M, Figueiredo JC, Gallinger SJ, Giles GG, Giovannucci E, Gruber SB, Gsur A, Hampe J, Hampel H, Harlid S, Harrison TA, Hoffmeister M, Hopper JL, Hsu L, María Huerta J, Huyghe JR, Jenkins MA, Keku TO, Kühn T, La Vecchia C, Le Marchand L, Li CI, Li L, Lindblom A, Lindor NM, Lynch B, Markowitz SD, Masala G, May AM, Milne R, Monninkhof E, Moreno L, Moreno V, Newcomb PA, Offit K, Perduca V, Pharoah PDP, Platz EA, Potter JD, Rennert G, Riboli E, Sánchez MJ, Schmit SL, Schoen RE, Severi G, Sieri S, Slattery ML, Song M, Tangen CM, Thibodeau SN, Travis RC, Trichopoulou A, Ulrich CM, van Duijnhoven FJB, Van Guelpen B, Vodicka P, White E, Wolk A, Woods MO, Wu AH, Peters U, Gunter MJ, Murphy N
Nat Commun 2020 Jan 30;11(1):597. doi: 10.1038/s41467-020-14389-8. PMID: 32001714Free PMC Article

Therapy

Bai Z, Zhou Y, Ye Z, Xiong J, Lan H, Wang F
Front Immunol 2021;12:808964. Epub 2022 Jan 14 doi: 10.3389/fimmu.2021.808964. PMID: 35095898Free PMC Article
Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T
Mol Neurodegener 2021 Mar 22;16(1):18. doi: 10.1186/s13024-021-00440-9. PMID: 33752701Free PMC Article
Li D, Patel CB, Xu G, Iagaru A, Zhu Z, Zhang L, Cheng Z
Front Immunol 2020;11:592389. Epub 2020 Oct 30 doi: 10.3389/fimmu.2020.592389. PMID: 33193439Free PMC Article
Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ, Kazmi N, Robinson TM, Albanes D, Aleksandrova K, Berndt SI, Timothy Bishop D, Brenner H, Buchanan DD, Bueno-de-Mesquita B, Campbell PT, Castellví-Bel S, Chan AT, Chang-Claude J, Ellingjord-Dale M, Figueiredo JC, Gallinger SJ, Giles GG, Giovannucci E, Gruber SB, Gsur A, Hampe J, Hampel H, Harlid S, Harrison TA, Hoffmeister M, Hopper JL, Hsu L, María Huerta J, Huyghe JR, Jenkins MA, Keku TO, Kühn T, La Vecchia C, Le Marchand L, Li CI, Li L, Lindblom A, Lindor NM, Lynch B, Markowitz SD, Masala G, May AM, Milne R, Monninkhof E, Moreno L, Moreno V, Newcomb PA, Offit K, Perduca V, Pharoah PDP, Platz EA, Potter JD, Rennert G, Riboli E, Sánchez MJ, Schmit SL, Schoen RE, Severi G, Sieri S, Slattery ML, Song M, Tangen CM, Thibodeau SN, Travis RC, Trichopoulou A, Ulrich CM, van Duijnhoven FJB, Van Guelpen B, Vodicka P, White E, Wolk A, Woods MO, Wu AH, Peters U, Gunter MJ, Murphy N
Nat Commun 2020 Jan 30;11(1):597. doi: 10.1038/s41467-020-14389-8. PMID: 32001714Free PMC Article
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487

Prognosis

Bai Z, Zhou Y, Ye Z, Xiong J, Lan H, Wang F
Front Immunol 2021;12:808964. Epub 2022 Jan 14 doi: 10.3389/fimmu.2021.808964. PMID: 35095898Free PMC Article
Qian Y, Li Y, Li R, Yang T, Jia R, Ge YZ
J Cell Mol Med 2021 Nov;25(22):10349-10361. Epub 2021 Oct 26 doi: 10.1111/jcmm.16996. PMID: 34697887Free PMC Article
Li D, Patel CB, Xu G, Iagaru A, Zhu Z, Zhang L, Cheng Z
Front Immunol 2020;11:592389. Epub 2020 Oct 30 doi: 10.3389/fimmu.2020.592389. PMID: 33193439Free PMC Article
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Sims JS, Ung TH, Neira JA, Canoll P, Bruce JN
J Neurooncol 2015 Jul;123(3):359-72. Epub 2015 Feb 28 doi: 10.1007/s11060-015-1746-9. PMID: 25724916Free PMC Article

Clinical prediction guides

Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Shakil S, Baig MH, Tabrez S, Rizvi SMD, Zaidi SK, Ashraf GM, Ansari SA, Khan AAP, Al-Qahtani MH, Abuzenadah AM, Chaudhary AG
Semin Cancer Biol 2019 Jun;56:47-55. Epub 2017 Nov 6 doi: 10.1016/j.semcancer.2017.11.004. PMID: 29122685
Surman M, Janik ME
Postepy Hig Med Dosw (Online) 2017 Jun 12;71(0):485-499. doi: 10.5604/01.3001.0010.3830. PMID: 28665278
Liggett LA, DeGregori J
Biochim Biophys Acta Rev Cancer 2017 Apr;1867(2):84-94. Epub 2017 Feb 4 doi: 10.1016/j.bbcan.2017.01.005. PMID: 28167050Free PMC Article
Sims JS, Ung TH, Neira JA, Canoll P, Bruce JN
J Neurooncol 2015 Jul;123(3):359-72. Epub 2015 Feb 28 doi: 10.1007/s11060-015-1746-9. PMID: 25724916Free PMC Article

Recent systematic reviews

Song Y, Qi X, Liu X
Gene 2020 Oct 5;757:144924. Epub 2020 Jul 2 doi: 10.1016/j.gene.2020.144924. PMID: 32622992
Gaba F, Manchanda R
Best Pract Res Clin Obstet Gynaecol 2020 May;65:46-65. Epub 2020 Feb 4 doi: 10.1016/j.bpobgyn.2020.01.006. PMID: 32192936
Quarles CC, Bell LC, Stokes AM
Neuroimage 2019 Feb 15;187:32-55. Epub 2018 May 3 doi: 10.1016/j.neuroimage.2018.04.069. PMID: 29729392Free PMC Article

Supplemental Content

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    Clinical resources

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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