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Plasma triglyceride level quantitative trait locus(TGQTL)

MedGen UID:
862990
•Concept ID:
C4014553
•
Finding
Synonyms: PLASMA TRIGLYCERIDE LEVEL QUANTITATIVE TRAIT LOCUS, LOW; TGQTL
 
Gene (location): ANGPTL4 (19p13.2)
 
OMIM®: 615881

Recent clinical studies

Etiology

Exploring the Role of Plasma Lipids and Statin Interventions on Multiple Sclerosis Risk and Severity: A Mendelian Randomization Study.
Almramhi MM, Finan C, Storm CS, Schmidt AF, Kia DA, Coneys R, Chopade S, Hingorani AD, Wood NW
Neurology 2023 Oct 24;101(17):e1729-e1740. Epub 2023 Sep 1 doi: 10.1212/WNL.0000000000207777. PMID: 37657941Free PMC Article
Genetic Evidence for a Causal Relationship between Hyperlipidemia and Type 2 Diabetes in Mice.
Shi LJ, Tang X, He J, Shi W
Int J Mol Sci 2022 May 31;23(11) doi: 10.3390/ijms23116184. PMID: 35682864Free PMC Article
Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes.
Jha P, McDevitt MT, Halilbasic E, Williams EG, Quiros PM, Gariani K, Sleiman MB, Gupta R, Ulbrich A, Jochem A, Coon JJ, Trauner M, Pagliarini DJ, Auwerx J
Cell Syst 2018 Jun 27;6(6):709-721.e6. Epub 2018 Jun 13 doi: 10.1016/j.cels.2018.05.009. PMID: 29909275Free PMC Article
Methods for meta-analysis of multiple traits using GWAS summary statistics.
Ray D, Boehnke M
Genet Epidemiol 2018 Mar;42(2):134-145. Epub 2017 Dec 10 doi: 10.1002/gepi.22105. PMID: 29226385Free PMC Article
Genome-wide scan for quantitative trait loci influencing LDL size and plasma triglyceride in familial hypertriglyceridemia.
Austin MA, Edwards KL, Monks SA, Koprowicz KM, Brunzell JD, Motulsky AG, Mahaney MC, Hixson JE
J Lipid Res 2003 Nov;44(11):2161-8. Epub 2003 Aug 16 doi: 10.1194/jlr.M300272-JLR200. PMID: 12923221

Diagnosis

Metabolic effects of genetic variation in the human REPIN1 gene.
Krüger J, Berger C, Weidle K, Schleinitz D, Tönjes A, Stumvoll M, Blüher M, Kovacs P, Klöting N
Int J Obes (Lond) 2019 Apr;43(4):821-831. Epub 2018 Jun 18 doi: 10.1038/s41366-018-0123-0. PMID: 29915365
Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study.
Lakka TA, Rankinen T, Rice T, Leon AS, Rao DC, Skinner JS, Bouchard C
Physiol Genomics 2006 Oct 11;27(2):103-7. Epub 2006 Jul 5 doi: 10.1152/physiolgenomics.00054.2005. PMID: 16822830
Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: the HERITAGE Family Study.
Feitosa MF, Rice T, North KE, Kraja A, Rankinen T, Leon AS, Skinner JS, Blangero J, Bouchard C, Rao DC
Atherosclerosis 2006 Apr;185(2):426-32. Epub 2005 Jul 25 doi: 10.1016/j.atherosclerosis.2005.06.023. PMID: 16046215

Therapy

Exploring the Role of Plasma Lipids and Statin Interventions on Multiple Sclerosis Risk and Severity: A Mendelian Randomization Study.
Almramhi MM, Finan C, Storm CS, Schmidt AF, Kia DA, Coneys R, Chopade S, Hingorani AD, Wood NW
Neurology 2023 Oct 24;101(17):e1729-e1740. Epub 2023 Sep 1 doi: 10.1212/WNL.0000000000207777. PMID: 37657941Free PMC Article
Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults.
Li B, Veturi Y, Verma A, Bradford Y, Daar ES, Gulick RM, Riddler SA, Robbins GK, Lennox JL, Haas DW, Ritchie MD
PLoS Genet 2021 Apr;17(4):e1009464. Epub 2021 Apr 26 doi: 10.1371/journal.pgen.1009464. PMID: 33901188Free PMC Article
Functional genetic variants of the catecholamine-release-inhibitory peptide catestatin in an Indian population: allele-specific effects on metabolic traits.
Sahu BS, Obbineni JM, Sahu G, Allu PK, Subramanian L, Sonawane PJ, Singh PK, Sasi BK, Senapati S, Maji SK, Bera AK, Gomathi BS, Mullasari AS, Mahapatra NR
J Biol Chem 2012 Dec 21;287(52):43840-52. Epub 2012 Oct 26 doi: 10.1074/jbc.M112.407916. PMID: 23105094Free PMC Article
Interactions between dietary fat intake and FASN genetic variation influence LDL peak particle diameter.
Dolley G, Boisclair ME, Lamarche B, Després JP, Bouchard C, Pérusse L, Vohl MC
J Nutrigenet Nutrigenomics 2011;4(3):137-45. Epub 2011 Jun 1 doi: 10.1159/000327778. PMID: 21646813
Pleiotropic QTL on chromosome 12q23-q24 influences triglyceride and high-density lipoprotein cholesterol levels: the HERITAGE family study.
Feitosa ME, Rice T, Borecki IB, Rankinen T, Leon AS, Skinner JS, Després JP, Blangero J, Bouchard C, Rao DC
Hum Biol 2006 Jun;78(3):317-27. doi: 10.1353/hub.2006.0043. PMID: 17216804

Prognosis

Exploring the Role of Plasma Lipids and Statin Interventions on Multiple Sclerosis Risk and Severity: A Mendelian Randomization Study.
Almramhi MM, Finan C, Storm CS, Schmidt AF, Kia DA, Coneys R, Chopade S, Hingorani AD, Wood NW
Neurology 2023 Oct 24;101(17):e1729-e1740. Epub 2023 Sep 1 doi: 10.1212/WNL.0000000000207777. PMID: 37657941Free PMC Article
Circulating YKL-40 level, but not CHI3L1 gene variants, is associated with atherosclerosis-related quantitative traits and the risk of peripheral artery disease.
Wu S, Hsu LA, Cheng ST, Teng MS, Yeh CH, Sun YC, Huang HL, Ko YL
Int J Mol Sci 2014 Dec 4;15(12):22421-37. doi: 10.3390/ijms151222421. PMID: 25486056Free PMC Article
WWOX gene is associated with HDL cholesterol and triglyceride levels.
Sáez ME, González-Pérez A, Martínez-Larrad MT, Gayán J, Real LM, Serrano-Ríos M, Ruiz A
BMC Med Genet 2010 Oct 14;11:148. doi: 10.1186/1471-2350-11-148. PMID: 20942981Free PMC Article
Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study.
Lakka TA, Rankinen T, Rice T, Leon AS, Rao DC, Skinner JS, Bouchard C
Physiol Genomics 2006 Oct 11;27(2):103-7. Epub 2006 Jul 5 doi: 10.1152/physiolgenomics.00054.2005. PMID: 16822830
Genome-wide scan for quantitative trait loci influencing LDL size and plasma triglyceride in familial hypertriglyceridemia.
Austin MA, Edwards KL, Monks SA, Koprowicz KM, Brunzell JD, Motulsky AG, Mahaney MC, Hixson JE
J Lipid Res 2003 Nov;44(11):2161-8. Epub 2003 Aug 16 doi: 10.1194/jlr.M300272-JLR200. PMID: 12923221

Clinical prediction guides

Exploring the Role of Plasma Lipids and Statin Interventions on Multiple Sclerosis Risk and Severity: A Mendelian Randomization Study.
Almramhi MM, Finan C, Storm CS, Schmidt AF, Kia DA, Coneys R, Chopade S, Hingorani AD, Wood NW
Neurology 2023 Oct 24;101(17):e1729-e1740. Epub 2023 Sep 1 doi: 10.1212/WNL.0000000000207777. PMID: 37657941Free PMC Article
Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes.
Jha P, McDevitt MT, Halilbasic E, Williams EG, Quiros PM, Gariani K, Sleiman MB, Gupta R, Ulbrich A, Jochem A, Coon JJ, Trauner M, Pagliarini DJ, Auwerx J
Cell Syst 2018 Jun 27;6(6):709-721.e6. Epub 2018 Jun 13 doi: 10.1016/j.cels.2018.05.009. PMID: 29909275Free PMC Article
Methods for meta-analysis of multiple traits using GWAS summary statistics.
Ray D, Boehnke M
Genet Epidemiol 2018 Mar;42(2):134-145. Epub 2017 Dec 10 doi: 10.1002/gepi.22105. PMID: 29226385Free PMC Article
Assessing association between protein truncating variants and quantitative traits.
Rivas MA, Pirinen M, Neville MJ, Gaulton KJ, Moutsianas L; GoT2D Consortium, Lindgren CM, Karpe F, McCarthy MI, Donnelly P
Bioinformatics 2013 Oct 1;29(19):2419-26. Epub 2013 Jul 16 doi: 10.1093/bioinformatics/btt409. PMID: 23860716Free PMC Article
INSIG1 influences obesity-related hypertriglyceridemia in humans.
Smith EM, Zhang Y, Baye TM, Gawrieh S, Cole R, Blangero J, Carless MA, Curran JE, Dyer TD, Abraham LJ, Moses EK, Kissebah AH, Martin LJ, Olivier M
J Lipid Res 2010 Apr;51(4):701-8. Epub 2009 Oct 21 doi: 10.1194/jlr.M001404. PMID: 19965593Free PMC Article

Supplemental Content

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    Related information

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    • GTR
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    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
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