U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tooth agenesis, selective, 7(STHAG7)

MedGen UID:
899184
•Concept ID:
C4225231
•
Disease or Syndrome
Synonym: STHAG7
 
Gene (location): LRP6 (12p13.2)
 
Monarch Initiative: MONDO:0014749
OMIM®: 616724

Definition

Any tooth agenesis in which the cause of the disease is a mutation in the LRP6 gene. [from MONDO]

Clinical features

From HPO
Taurodontism
MedGen UID:
75596
•Concept ID:
C0266039
•
Disease or Syndrome
Increased volume of dental pulp of permanent molar characterized by a crown body-root ratio equal or larger than 1:1 or an elongated pulp chambers and apical displacement of the bifurcation or trifurcation of the roots.
See: Feature record | Search on this feature
Agenesis of permanent teeth
MedGen UID:
224851
•Concept ID:
C1290511
•
Congenital Abnormality
A congenital defect characterized by the absence of one or more permanent teeth, including oligodontia, hypodontia, and adontia of the of permanent teeth.
See: Feature record | Search on this feature

Professional guidelines

PubMed

The effect of endodontics and crown restoration techniques on the prognosis of treatment non-vital teeth.
Fastovets OO, Kotelevskyi RA, Matvyeyenko RY
Wiad Lek 2018;71(9):1738-1741. PMID: 30737932
White-spot lesions during multibracket appliance treatment: A challenge for clinical excellence.
Enaia M, Bock N, Ruf S
Am J Orthod Dentofacial Orthop 2011 Jul;140(1):e17-24. doi: 10.1016/j.ajodo.2010.12.016. PMID: 21724067

Recent clinical studies

Etiology

Risk of Dental Discoloration and Enamel Dysplasia in Children Exposed to Tetracycline and Its Derivatives.
Kim SJ, Kim EH, Lee M, Baek JY, Lee JY, Shin JH, Lim SM, Kim MY, Jung I, Ahn JG, Kang CM, Kang JM
Yonsei Med J 2022 Dec;63(12):1113-1120. doi: 10.3349/ymj.2022.0388. PMID: 36444547Free PMC Article
Diagnostic and severity scores for Cockayne syndrome.
Spitz MA, Severac F, Obringer C, Baer S, Le May N, Calmels N, Laugel V
Orphanet J Rare Dis 2021 Feb 3;16(1):63. doi: 10.1186/s13023-021-01686-8. PMID: 33536051Free PMC Article
Long-Term Effects of Distraction Osteogenesis of the Mandible.
Peacock ZS, Salcines A, Troulis MJ, Kaban LB
J Oral Maxillofac Surg 2018 Jul;76(7):1512-1523. Epub 2018 Jan 31 doi: 10.1016/j.joms.2017.12.034. PMID: 29425758
Morphologic and Demographic Predictors of Third Molar Agenesis: A Systematic Review and Meta-analysis.
Carter K, Worthington S
J Dent Res 2015 Jul;94(7):886-94. Epub 2015 Apr 16 doi: 10.1177/0022034515581644. PMID: 25883107
Prevalence of hypodontia and associated factors: a systematic review and meta-analysis.
Khalaf K, Miskelly J, Voge E, Macfarlane TV
J Orthod 2014 Dec;41(4):299-316. doi: 10.1179/1465313314Y.0000000116. PMID: 25404667

Diagnosis

Comparison of root and canal anatomy of taurodont and normal molar teeth: A retrospective cone-beam computed tomography study.
Aydın H, Mobaraki S
Arch Oral Biol 2021 Oct;130:105242. Epub 2021 Aug 13 doi: 10.1016/j.archoralbio.2021.105242. PMID: 34411883
Orofacial signs and dental abnormalities in patients with Mulvihill-Smith syndrome: A literature review on this rare progeroid pathology.
Passarelli PC, Pasquantonio G, Manicone PF, Cerroni L, Condo' R, Mancini M, D'Addona A
Medicine (Baltimore) 2018 May;97(18):e0656. doi: 10.1097/MD.0000000000010656. PMID: 29718885Free PMC Article
Prenatal ultrasound and postmortem histologic evaluation of tooth germs: an observational, transversal study.
Seabra M, Felino A, Nogueira R, Valente F, Braga AC, Vaz P
Head Face Med 2015 May 12;11:18. doi: 10.1186/s13005-015-0075-8. PMID: 25962445Free PMC Article
Prevalence of hypodontia and associated factors: a systematic review and meta-analysis.
Khalaf K, Miskelly J, Voge E, Macfarlane TV
J Orthod 2014 Dec;41(4):299-316. doi: 10.1179/1465313314Y.0000000116. PMID: 25404667
The genetic basis of inherited anomalies of the teeth. Part 2: syndromes with significant dental involvement.
Bailleul-Forestier I, Berdal A, Vinckier F, de Ravel T, Fryns JP, Verloes A
Eur J Med Genet 2008 Sep-Oct;51(5):383-408. Epub 2008 May 23 doi: 10.1016/j.ejmg.2008.05.003. PMID: 18599376

Therapy

Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis.
Fonseca-Souza G, de Oliveira LB, Wambier LM, Scariot R, Feltrin-Souza J
Clin Oral Investig 2022 Aug;26(8):5089-5103. Epub 2022 Jun 21 doi: 10.1007/s00784-022-04540-8. PMID: 35729285
Comparison of root and canal anatomy of taurodont and normal molar teeth: A retrospective cone-beam computed tomography study.
Aydın H, Mobaraki S
Arch Oral Biol 2021 Oct;130:105242. Epub 2021 Aug 13 doi: 10.1016/j.archoralbio.2021.105242. PMID: 34411883
Blepharocheilodontic (BCD) syndrome: New insights on craniofacial and dental features.
Awadh W, Kiukkonen A, Nieminen P, Arte S, Hurmerinta K, Rice DP
Am J Med Genet A 2017 Apr;173(4):905-913. Epub 2017 Feb 9 doi: 10.1002/ajmg.a.38088. PMID: 28181393
Prenatal ultrasound and postmortem histologic evaluation of tooth germs: an observational, transversal study.
Seabra M, Felino A, Nogueira R, Valente F, Braga AC, Vaz P
Head Face Med 2015 May 12;11:18. doi: 10.1186/s13005-015-0075-8. PMID: 25962445Free PMC Article
Results after wisdom tooth transplantation. A retrospective study.
Schütz S, Beck I, Kühl S, Filippi A
Schweiz Monatsschr Zahnmed 2013;123(4):303-13. PMID: 23640290

Prognosis

A Case Against the Implant.
Robbins JW
Int J Periodontics Restorative Dent 2024 May 24;44(3):250-251. doi: 10.11607/prd.2024.3.e. PMID: 38787712
Diagnostic and severity scores for Cockayne syndrome.
Spitz MA, Severac F, Obringer C, Baer S, Le May N, Calmels N, Laugel V
Orphanet J Rare Dis 2021 Feb 3;16(1):63. doi: 10.1186/s13023-021-01686-8. PMID: 33536051Free PMC Article
The effect of endodontics and crown restoration techniques on the prognosis of treatment non-vital teeth.
Fastovets OO, Kotelevskyi RA, Matvyeyenko RY
Wiad Lek 2018;71(9):1738-1741. PMID: 30737932
Birth-Weight, Pregnancy Term, Pre-Natal and Natal Complications Related to Child's Dental Anomalies.
Prokocimer T, Amir E, Blumer S, Peretz B
J Clin Pediatr Dent 2015 Summer;39(4):371-6. doi: 10.17796/1053-4628-39.4.371. PMID: 26161610
Morphologic and Demographic Predictors of Third Molar Agenesis: A Systematic Review and Meta-analysis.
Carter K, Worthington S
J Dent Res 2015 Jul;94(7):886-94. Epub 2015 Apr 16 doi: 10.1177/0022034515581644. PMID: 25883107

Clinical prediction guides

A Case Against the Implant.
Robbins JW
Int J Periodontics Restorative Dent 2024 May 24;44(3):250-251. doi: 10.11607/prd.2024.3.e. PMID: 38787712
The role of clinical examination in the detection of permanent maxillary molars with two palatal roots.
Hitij T, Štamfelj I
Folia Morphol (Warsz) 2020;79(1):127-133. Epub 2019 May 7 doi: 10.5603/FM.a2019.0054. PMID: 31063199
Birth-Weight, Pregnancy Term, Pre-Natal and Natal Complications Related to Child's Dental Anomalies.
Prokocimer T, Amir E, Blumer S, Peretz B
J Clin Pediatr Dent 2015 Summer;39(4):371-6. doi: 10.17796/1053-4628-39.4.371. PMID: 26161610
Morphologic and Demographic Predictors of Third Molar Agenesis: A Systematic Review and Meta-analysis.
Carter K, Worthington S
J Dent Res 2015 Jul;94(7):886-94. Epub 2015 Apr 16 doi: 10.1177/0022034515581644. PMID: 25883107
Results after wisdom tooth transplantation. A retrospective study.
Schütz S, Beck I, Kühl S, Filippi A
Schweiz Monatsschr Zahnmed 2013;123(4):303-13. PMID: 23640290

Recent systematic reviews

Self-correction of the ectopic eruption of the maxillary first permanent molar and its predictive factors: A systematic review.
Bastos RTDRM, Dos Santos CCO, Bellini-Pereira SA, Normando D
Int J Paediatr Dent 2024 Jul;34(4):348-359. Epub 2023 Oct 24 doi: 10.1111/ipd.13131. PMID: 37876132
Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis.
Fonseca-Souza G, de Oliveira LB, Wambier LM, Scariot R, Feltrin-Souza J
Clin Oral Investig 2022 Aug;26(8):5089-5103. Epub 2022 Jun 21 doi: 10.1007/s00784-022-04540-8. PMID: 35729285
Morphologic and Demographic Predictors of Third Molar Agenesis: A Systematic Review and Meta-analysis.
Carter K, Worthington S
J Dent Res 2015 Jul;94(7):886-94. Epub 2015 Apr 16 doi: 10.1177/0022034515581644. PMID: 25883107
Prevalence of hypodontia and associated factors: a systematic review and meta-analysis.
Khalaf K, Miskelly J, Voge E, Macfarlane TV
J Orthod 2014 Dec;41(4):299-316. doi: 10.1179/1465313314Y.0000000116. PMID: 25404667

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...