Upturning of the big toe (and sometimes fanning of the other toes) in response to stimulation of the sole of the foot. If the Babinski sign is present it can indicate damage to the corticospinal tract.

Spasticity and weakness of the leg and hip muscles.

Hyperreflexia is the presence of hyperactive stretch reflexes of the muscles.

Absence of neurologic reflexes such as the knee-jerk reaction.

An abnormality characterized by disruption of the normal functioning of peripheral axons.

An abnormal reduction in sensation in the distal portions of the extremities.

Atrophy of the optic nerve. Optic atrophy results from the death of the retinal ganglion cell axons that comprise the optic nerve and manifesting as a pale optic nerve on fundoscopy.

Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery.

An absolute or relative reduction in the extent of the normal field of vision.