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Attention deficit-hyperactivity disorder 8(ADHD8)

MedGen UID:
1808030
Concept ID:
C5677018
Mental or Behavioral Dysfunction
Synonym: ADHD8
 
Gene (location): CDH2 (18q12.1)
 
Monarch Initiative: MONDO:0859261
OMIM®: 619957

Definition

Attention deficit-hyperactivity disorder-8 (ADHD8) is a severe early-childhood neuropsychiatric disorder characterized by a persistent pattern of hyperactive behavior and impulsivity (Halperin et al., 2021). For a general phenotypic description and a discussion of genetic heterogeneity of attention deficit-hyperactivity disorder, see 143465. [from OMIM]

Clinical features

From HPO
Attention deficit hyperactivity disorder
MedGen UID:
220387
Concept ID:
C1263846
Mental or Behavioral Dysfunction
Attention-deficit/hyperactivity disorder (ADHD) is a behavioral disorder that typically begins in childhood and is characterized by a short attention span (inattention), an inability to be calm and stay still (hyperactivity), and poor impulse control (impulsivity). Some people with ADHD have problems with only inattention or with hyperactivity and impulsivity, but most have problems related to all three features.\n\nIn people with ADHD, the characteristic behaviors are frequent and severe enough to interfere with the activities of daily living such as school, work, and relationships with others. Because of an inability to stay focused on tasks, people with inattention may be easily distracted, forgetful, avoid tasks that require sustained attention, have difficulty organizing tasks, or frequently lose items.\n\nHyperactivity is usually shown by frequent movement. Individuals with this feature often fidget or tap their foot when seated, leave their seat when it is inappropriate to do so (such as in the classroom), or talk a lot and interrupt others.\n\nImpulsivity can result in hasty actions without thought for the consequences. Individuals with poor impulse control may have difficulty waiting for their turn, deferring to others, or considering their actions before acting.\n\nMore than two-thirds of all individuals with ADHD have additional conditions, including insomnia, mood or anxiety disorders, learning disorders, or substance use disorders. Affected individuals may also have autism spectrum disorder, which is characterized by impaired communication and social interaction, or Tourette syndrome, which is a disorder characterized by repetitive and involuntary movements or noises called tics.\n\nIn most affected individuals, ADHD continues throughout life, but in about one-third of individuals, signs and symptoms of ADHD go away by adulthood.
Mild global developmental delay
MedGen UID:
861405
Concept ID:
C4012968
Finding
A mild delay in the achievement of motor or mental milestones in the domains of development of a child.

Professional guidelines

PubMed

May T, Birch E, Chaves K, Cranswick N, Culnane E, Delaney J, Derrick M, Eapen V, Edlington C, Efron D, Ewais T, Garner I, Gathercole M, Jagadheesan K, Jobson L, Kramer J, Mack M, Misso M, Murrup-Stewart C, Savage E, Sciberras E, Singh B, Testa R, Vale L, Weirman A, Petch E, Williams K, Bellgrove M
Aust N Z J Psychiatry 2023 Aug;57(8):1101-1116. Epub 2023 May 30 doi: 10.1177/00048674231166329. PMID: 37254562Free PMC Article
Coghill D, Banaschewski T, Cortese S, Asherson P, Brandeis D, Buitelaar J, Daley D, Danckaerts M, Dittmann RW, Doepfner M, Ferrin M, Hollis C, Holtmann M, Paramala S, Sonuga-Barke E, Soutullo C, Steinhausen HC, Van der Oord S, Wong ICK, Zuddas A, Simonoff E
Eur Child Adolesc Psychiatry 2023 Aug;32(8):1337-1361. Epub 2021 Oct 22 doi: 10.1007/s00787-021-01871-x. PMID: 34677682Free PMC Article
Cichoń L, Janas-Kozik M, Siwiec A, Rybakowski JK
Psychiatr Pol 2020 Mar 29;54(1):35-50. doi: 10.12740/PP/OnlineFirst/92740. PMID: 32447355

Recent clinical studies

Etiology

Wong SYS, Chan SKC, Yip BHK, Wang W, Lo HHM, Zhang D, Bögels SM
Psychother Psychosom 2023;92(6):379-390. Epub 2023 Dec 1 doi: 10.1159/000534962. PMID: 38043516Free PMC Article
S Alamri A
Pak J Biol Sci 2021 Jan;24(8):913-919. doi: 10.3923/pjbs.2021.913.919. PMID: 34486359
Del-Ponte B, Anselmi L, Assunção MCF, Tovo-Rodrigues L, Munhoz TN, Matijasevich A, Rohde LA, Santos IS
J Affect Disord 2019 Jan 15;243:290-296. Epub 2018 Sep 17 doi: 10.1016/j.jad.2018.09.051. PMID: 30257225Free PMC Article
Banerjee TD, Middleton F, Faraone SV
Acta Paediatr 2007 Sep;96(9):1269-74. doi: 10.1111/j.1651-2227.2007.00430.x. PMID: 17718779
Biederman J, Faraone SV
Lancet 2005 Jul 16-22;366(9481):237-48. doi: 10.1016/S0140-6736(05)66915-2. PMID: 16023516

Diagnosis

Anbarasan D, Kitchin M, Adler LA
Curr Psychiatry Rep 2020 Oct 23;22(12):72. doi: 10.1007/s11920-020-01194-9. PMID: 33095375
Salvi V, Migliarese G, Venturi V, Rossi F, Torriero S, Viganò V, Cerveri G, Mencacci C
Riv Psichiatr 2019 Mar-Apr;54(2):84-89. doi: 10.1708/3142.31249. PMID: 30985833
Del-Ponte B, Anselmi L, Assunção MCF, Tovo-Rodrigues L, Munhoz TN, Matijasevich A, Rohde LA, Santos IS
J Affect Disord 2019 Jan 15;243:290-296. Epub 2018 Sep 17 doi: 10.1016/j.jad.2018.09.051. PMID: 30257225Free PMC Article
Thomas R, Sanders S, Doust J, Beller E, Glasziou P
Pediatrics 2015 Apr;135(4):e994-1001. Epub 2015 Mar 2 doi: 10.1542/peds.2014-3482. PMID: 25733754
Biederman J, Faraone SV
Lancet 2005 Jul 16-22;366(9481):237-48. doi: 10.1016/S0140-6736(05)66915-2. PMID: 16023516

Therapy

Rubia K, Westwood S, Aggensteiner PM, Brandeis D
Cells 2021 Aug 21;10(8) doi: 10.3390/cells10082156. PMID: 34440925Free PMC Article
Sciberras E, Efron D, Patel P, Mulraney M, Lee KJ, Mihalopoulos C, Engel L, Rapee RM, Anderson V, Nicholson JM, Schembri R, Hiscock H
BMC Psychiatry 2019 Nov 13;19(1):359. doi: 10.1186/s12888-019-2276-3. PMID: 31722690Free PMC Article
Del-Ponte B, Anselmi L, Assunção MCF, Tovo-Rodrigues L, Munhoz TN, Matijasevich A, Rohde LA, Santos IS
J Affect Disord 2019 Jan 15;243:290-296. Epub 2018 Sep 17 doi: 10.1016/j.jad.2018.09.051. PMID: 30257225Free PMC Article
Thomas R, Sanders S, Doust J, Beller E, Glasziou P
Pediatrics 2015 Apr;135(4):e994-1001. Epub 2015 Mar 2 doi: 10.1542/peds.2014-3482. PMID: 25733754
Banerjee TD, Middleton F, Faraone SV
Acta Paediatr 2007 Sep;96(9):1269-74. doi: 10.1111/j.1651-2227.2007.00430.x. PMID: 17718779

Prognosis

Sibley MH, Kennedy TM, Swanson JM, Arnold LE, Jensen PS, Hechtman LT, Molina BSG, Howard A, Greenhill L, Chronis-Tuscano A, Mitchell JT, Newcorn JH, Rohde LA, Hinshaw SP
J Clin Psychiatry 2024 Oct 16;85(4) doi: 10.4088/JCP.24m15395. PMID: 39431909
Li L, Zhu N, Zhang L, Kuja-Halkola R, D'Onofrio BM, Brikell I, Lichtenstein P, Cortese S, Larsson H, Chang Z
JAMA 2024 Mar 12;331(10):850-860. doi: 10.1001/jama.2024.0851. PMID: 38470385Free PMC Article
Salvi V, Migliarese G, Venturi V, Rossi F, Torriero S, Viganò V, Cerveri G, Mencacci C
Riv Psichiatr 2019 Mar-Apr;54(2):84-89. doi: 10.1708/3142.31249. PMID: 30985833
Cooper RE, Williams E, Seegobin S, Tye C, Kuntsi J, Asherson P
Eur Neuropsychopharmacol 2017 Aug;27(8):795-808. Epub 2017 May 30 doi: 10.1016/j.euroneuro.2017.05.005. PMID: 28576350
Weinstein A, Lejoyeux M
Am J Drug Alcohol Abuse 2010 Sep;36(5):277-83. doi: 10.3109/00952990.2010.491880. PMID: 20545603

Clinical prediction guides

Wong SYS, Chan SKC, Yip BHK, Wang W, Lo HHM, Zhang D, Bögels SM
Psychother Psychosom 2023;92(6):379-390. Epub 2023 Dec 1 doi: 10.1159/000534962. PMID: 38043516Free PMC Article
Du R, Zhou Y, You C, Liu K, King DA, Liang ZS, Ranson JM, Llewellyn DJ, Huang J, Zhang Z
Int J Stroke 2023 Mar;18(3):346-353. Epub 2022 Jul 6 doi: 10.1177/17474930221108272. PMID: 35670701
Hontelez S, Stobernack T, Pelsser LM, van Baarlen P, Frankena K, Groefsema MM, Kleerebezem M, Rodrigues Pereira R, Postma EM, Smeets PAM, Stopyra MA, Zwiers MP, Aarts E
Sci Rep 2021 Nov 12;11(1):22205. doi: 10.1038/s41598-021-01684-7. PMID: 34772996Free PMC Article
Salvi V, Migliarese G, Venturi V, Rossi F, Torriero S, Viganò V, Cerveri G, Mencacci C
Riv Psichiatr 2019 Mar-Apr;54(2):84-89. doi: 10.1708/3142.31249. PMID: 30985833
Sprich SE, Safren SA, Finkelstein D, Remmert JE, Hammerness P
J Child Psychol Psychiatry 2016 Nov;57(11):1218-1226. Epub 2016 Mar 17 doi: 10.1111/jcpp.12549. PMID: 26990084Free PMC Article

Recent systematic reviews

Salari N, Ghasemi H, Abdoli N, Rahmani A, Shiri MH, Hashemian AH, Akbari H, Mohammadi M
Ital J Pediatr 2023 Apr 20;49(1):48. doi: 10.1186/s13052-023-01456-1. PMID: 37081447Free PMC Article
Storebø OJ, Storm MRO, Pereira Ribeiro J, Skoog M, Groth C, Callesen HE, Schaug JP, Darling Rasmussen P, Huus CL, Zwi M, Kirubakaran R, Simonsen E, Gluud C
Cochrane Database Syst Rev 2023 Mar 27;3(3):CD009885. doi: 10.1002/14651858.CD009885.pub3. PMID: 36971690Free PMC Article
GBD 2019 Mental Disorders Collaborators
Lancet Psychiatry 2022 Feb;9(2):137-150. Epub 2022 Jan 10 doi: 10.1016/S2215-0366(21)00395-3. PMID: 35026139Free PMC Article
Nazar BP, Bernardes C, Peachey G, Sergeant J, Mattos P, Treasure J
Int J Eat Disord 2016 Dec;49(12):1045-1057. Epub 2016 Nov 15 doi: 10.1002/eat.22643. PMID: 27859581
Thomas R, Sanders S, Doust J, Beller E, Glasziou P
Pediatrics 2015 Apr;135(4):e994-1001. Epub 2015 Mar 2 doi: 10.1542/peds.2014-3482. PMID: 25733754

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