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Primary degenerative dementia of the Alzheimer type, presenile onset

MedGen UID:
1830291
•Concept ID:
C5779573
•
Disease or Syndrome
Synonyms: Alzheimer disease, early onset; Early-onset Alzheimer's disease
SNOMED CT: Primary degenerative dementia of the Alzheimer type, presenile onset (416780008); Primary degenerative dementia of the Alzheimer type, early onset (416780008); Dementia in Alzheimer's disease with early onset (416780008); Dementia of the Alzheimers type with early onset (416780008); Presenile dementia, Alzheimer's type (416780008); Alzheimer's disease with early onset (416780008); Dementia in Alzheimer's disease - type 2 (416780008)

Recent clinical studies

Etiology

Usefulness of biomarkers in the diagnosis and prognosis of early-onset cognitive impairment.
Balasa M, Sánchez-Valle R, Antonell A, Bosch B, Olives J, Rami L, Castellví M, Molinuevo JL, Lladó A
J Alzheimers Dis 2014;40(4):919-27. doi: 10.3233/JAD-132195. PMID: 24577466
Duration of EEG alpha wave blockade by tone stimulation is prolonged in early stage of presenile onset dementia of the Alzheimer type.
Müller G, Richter RA, Weisbrod S, Klingberg F
Biomed Biochim Acta 1991;50(8):987-91. PMID: 1781778
Gray-matter degeneration in presenile Alzheimer's disease.
Prohovnik I, Smith G, Sackeim HA, Mayeux R, Stern Y
Ann Neurol 1989 Feb;25(2):117-24. doi: 10.1002/ana.410250203. PMID: 2919865

Diagnosis

Usefulness of biomarkers in the diagnosis and prognosis of early-onset cognitive impairment.
Balasa M, Sánchez-Valle R, Antonell A, Bosch B, Olives J, Rami L, Castellví M, Molinuevo JL, Lladó A
J Alzheimers Dis 2014;40(4):919-27. doi: 10.3233/JAD-132195. PMID: 24577466
A pre-senile case of limbic encephalitis and cerebellar degeneration, with subacute onset of progressive dementia.
Mori O, Yamazaki M, Yamazaki M, Komiyama T, Ohaki Y, Katayama Y, Naito Z
J Nippon Med Sch 2004 Dec;71(6):412-6. doi: 10.1272/jnms.71.412. PMID: 15673963
Neuropathological findings in patients with clinical diagnoses of probable Alzheimer's disease.
Risse SC, Raskind MA, Nochlin D, Sumi SM, Lampe TH, Bird TD, Cubberley L, Peskind ER
Am J Psychiatry 1990 Feb;147(2):168-72. doi: 10.1176/ajp.147.2.168. PMID: 2301654
Gray-matter degeneration in presenile Alzheimer's disease.
Prohovnik I, Smith G, Sackeim HA, Mayeux R, Stern Y
Ann Neurol 1989 Feb;25(2):117-24. doi: 10.1002/ana.410250203. PMID: 2919865

Prognosis

Usefulness of biomarkers in the diagnosis and prognosis of early-onset cognitive impairment.
Balasa M, Sánchez-Valle R, Antonell A, Bosch B, Olives J, Rami L, Castellví M, Molinuevo JL, Lladó A
J Alzheimers Dis 2014;40(4):919-27. doi: 10.3233/JAD-132195. PMID: 24577466
Gray-matter degeneration in presenile Alzheimer's disease.
Prohovnik I, Smith G, Sackeim HA, Mayeux R, Stern Y
Ann Neurol 1989 Feb;25(2):117-24. doi: 10.1002/ana.410250203. PMID: 2919865

Clinical prediction guides

Usefulness of biomarkers in the diagnosis and prognosis of early-onset cognitive impairment.
Balasa M, Sánchez-Valle R, Antonell A, Bosch B, Olives J, Rami L, Castellví M, Molinuevo JL, Lladó A
J Alzheimers Dis 2014;40(4):919-27. doi: 10.3233/JAD-132195. PMID: 24577466
A pre-senile case of limbic encephalitis and cerebellar degeneration, with subacute onset of progressive dementia.
Mori O, Yamazaki M, Yamazaki M, Komiyama T, Ohaki Y, Katayama Y, Naito Z
J Nippon Med Sch 2004 Dec;71(6):412-6. doi: 10.1272/jnms.71.412. PMID: 15673963

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