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mTOR Inhibitor response

MedGen UID:
1002027
Concept ID:
CN322755
Sign or Symptom
Synonym: mTOR inhibitor immunosuppressant response
Drug:
mTOR Inhibitor
MedGen UID:
411559
Concept ID:
C2746052
Pharmacologic Substance
Any substance that inhibits mammalian target of rapamycin (mTOR or FK506 binding protein 12-rapamycin associated protein 1 (FRAP1)), a serine/threonine protein kinase that is active in the control of cell growth, cell proliferation, and cell motility. Inhibition of mTOR can inhibit cell proliferation. [from NCI]

Professional guidelines

PubMed

Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Wilson BN, John AM, Handler MZ, Schwartz RA
J Am Acad Dermatol 2021 Jun;84(6):1667-1676. Epub 2020 Aug 6 doi: 10.1016/j.jaad.2020.07.105. PMID: 32771543
Lee L, Ito T, Jensen RT
Expert Opin Pharmacother 2018 Jun;19(8):909-928. Epub 2018 May 24 doi: 10.1080/14656566.2018.1476492. PMID: 29757017Free PMC Article

Recent clinical studies

Etiology

Yu J, Ling S, Hong J, Zhang L, Zhou W, Yin L, Xu S, Que Q, Wu Y, Zhan Q, Bao J, Xu N, Liu Y, Chen K, Wei X, Liu Z, Feng T, Zhou L, Xie H, Wang S, Liu J, Zheng S, Xu X
J Immunother Cancer 2023 Nov 29;11(11) doi: 10.1136/jitc-2023-007479. PMID: 38030304Free PMC Article
Canaud G, Hammill AM, Adams D, Vikkula M, Keppler-Noreuil KM
Orphanet J Rare Dis 2021 Jul 8;16(1):306. doi: 10.1186/s13023-021-01929-8. PMID: 34238334Free PMC Article
Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, Lonetto MA, Maecker HT, Kovarik J, Carson S, Glass DJ, Klickstein LB
Sci Transl Med 2014 Dec 24;6(268):268ra179. doi: 10.1126/scitranslmed.3009892. PMID: 25540326
Schulze M, Stock C, Zaccagnini M, Teber D, Rassweiler JJ
Recent Results Cancer Res 2014;201:393-403. doi: 10.1007/978-3-642-54490-3_24. PMID: 24756806
Baselga J, Campone M, Piccart M, Burris HA 3rd, Rugo HS, Sahmoud T, Noguchi S, Gnant M, Pritchard KI, Lebrun F, Beck JT, Ito Y, Yardley D, Deleu I, Perez A, Bachelot T, Vittori L, Xu Z, Mukhopadhyay P, Lebwohl D, Hortobagyi GN
N Engl J Med 2012 Feb 9;366(6):520-9. Epub 2011 Dec 7 doi: 10.1056/NEJMoa1109653. PMID: 22149876Free PMC Article

Diagnosis

Canaud G, Hammill AM, Adams D, Vikkula M, Keppler-Noreuil KM
Orphanet J Rare Dis 2021 Jul 8;16(1):306. doi: 10.1186/s13023-021-01929-8. PMID: 34238334Free PMC Article
Franzin R, Netti GS, Spadaccino F, Porta C, Gesualdo L, Stallone G, Castellano G, Ranieri E
Front Immunol 2020;11:574271. Epub 2020 Oct 8 doi: 10.3389/fimmu.2020.574271. PMID: 33162990Free PMC Article
Graillon T, Sanson M, Campello C, Idbaih A, Peyre M, Peyrière H, Basset N, Autran D, Roche C, Kalamarides M, Roche PH, Fuentes S, Tabouret E, Barrie M, Cohen A, Honoré S, Boucekine M, Baumstarck K, Figarella-Branger D, Barlier A, Dufour H, Chinot OL
Clin Cancer Res 2020 Feb 1;26(3):552-557. Epub 2020 Jan 22 doi: 10.1158/1078-0432.CCR-19-2109. PMID: 31969329
Rahmani M, Nkwocha J, Hawkins E, Pei X, Parker RE, Kmieciak M, Leverson JD, Sampath D, Ferreira-Gonzalez A, Grant S
Cancer Res 2018 Jun 1;78(11):3075-3086. Epub 2018 Mar 20 doi: 10.1158/0008-5472.CAN-17-3024. PMID: 29559471Free PMC Article
Baselga J, Campone M, Piccart M, Burris HA 3rd, Rugo HS, Sahmoud T, Noguchi S, Gnant M, Pritchard KI, Lebrun F, Beck JT, Ito Y, Yardley D, Deleu I, Perez A, Bachelot T, Vittori L, Xu Z, Mukhopadhyay P, Lebwohl D, Hortobagyi GN
N Engl J Med 2012 Feb 9;366(6):520-9. Epub 2011 Dec 7 doi: 10.1056/NEJMoa1109653. PMID: 22149876Free PMC Article

Therapy

Barchiesi G, Mazzotta M, Krasniqi E, Pizzuti L, Marinelli D, Capomolla E, Sergi D, Amodio A, Natoli C, Gamucci T, Vizza E, Marchetti P, Botti C, Sanguineti G, Ciliberto G, Barba M, Vici P
Int J Mol Sci 2020 May 16;21(10) doi: 10.3390/ijms21103528. PMID: 32429381Free PMC Article
Graillon T, Sanson M, Campello C, Idbaih A, Peyre M, Peyrière H, Basset N, Autran D, Roche C, Kalamarides M, Roche PH, Fuentes S, Tabouret E, Barrie M, Cohen A, Honoré S, Boucekine M, Baumstarck K, Figarella-Branger D, Barlier A, Dufour H, Chinot OL
Clin Cancer Res 2020 Feb 1;26(3):552-557. Epub 2020 Jan 22 doi: 10.1158/1078-0432.CCR-19-2109. PMID: 31969329
Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, Lonetto MA, Maecker HT, Kovarik J, Carson S, Glass DJ, Klickstein LB
Sci Transl Med 2014 Dec 24;6(268):268ra179. doi: 10.1126/scitranslmed.3009892. PMID: 25540326
Baselga J, Campone M, Piccart M, Burris HA 3rd, Rugo HS, Sahmoud T, Noguchi S, Gnant M, Pritchard KI, Lebrun F, Beck JT, Ito Y, Yardley D, Deleu I, Perez A, Bachelot T, Vittori L, Xu Z, Mukhopadhyay P, Lebwohl D, Hortobagyi GN
N Engl J Med 2012 Feb 9;366(6):520-9. Epub 2011 Dec 7 doi: 10.1056/NEJMoa1109653. PMID: 22149876Free PMC Article
Stock C, Zaccagnini M, Schulze M, Teber D, Rassweiler JJ
Recent Results Cancer Res 2010;184:189-97. doi: 10.1007/978-3-642-01222-8_13. PMID: 20072839

Prognosis

He Y, Wang X
Comput Biol Med 2023 Dec;167:107591. Epub 2023 Oct 18 doi: 10.1016/j.compbiomed.2023.107591. PMID: 37875043
Choueiri TK, Eto M, Motzer R, De Giorgi U, Buchler T, Basappa NS, Méndez-Vidal MJ, Tjulandin S, Hoon Park S, Melichar B, Hutson T, Alemany C, McGregor B, Powles T, Grünwald V, Alekseev B, Rha SY, Kopyltsov E, Kapoor A, Alonso Gordoa T, Goh JC, Staehler M, Merchan JR, Xie R, Perini RF, Mody K, McKenzie J, Porta CG
Lancet Oncol 2023 Mar;24(3):228-238. doi: 10.1016/S1470-2045(23)00049-9. PMID: 36858721
Schmitt M, Ceteci F, Gupta J, Pesic M, Böttger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisözü A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR
Nature 2022 Dec;612(7939):347-353. Epub 2022 Nov 16 doi: 10.1038/s41586-022-05426-1. PMID: 36385525Free PMC Article
Graillon T, Sanson M, Campello C, Idbaih A, Peyre M, Peyrière H, Basset N, Autran D, Roche C, Kalamarides M, Roche PH, Fuentes S, Tabouret E, Barrie M, Cohen A, Honoré S, Boucekine M, Baumstarck K, Figarella-Branger D, Barlier A, Dufour H, Chinot OL
Clin Cancer Res 2020 Feb 1;26(3):552-557. Epub 2020 Jan 22 doi: 10.1158/1078-0432.CCR-19-2109. PMID: 31969329
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544

Clinical prediction guides

Yu J, Ling S, Hong J, Zhang L, Zhou W, Yin L, Xu S, Que Q, Wu Y, Zhan Q, Bao J, Xu N, Liu Y, Chen K, Wei X, Liu Z, Feng T, Zhou L, Xie H, Wang S, Liu J, Zheng S, Xu X
J Immunother Cancer 2023 Nov 29;11(11) doi: 10.1136/jitc-2023-007479. PMID: 38030304Free PMC Article
Yu L, Wei J, Liu P
Semin Cancer Biol 2022 Oct;85:69-94. Epub 2021 Jun 25 doi: 10.1016/j.semcancer.2021.06.019. PMID: 34175443
Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM
Nature 2018 Aug;560(7718):387-391. Epub 2018 Jun 20 doi: 10.1038/s41586-018-0290-0. PMID: 29925955Free PMC Article
Catena V, Fanciulli M
J Exp Clin Cancer Res 2017 Jan 13;36(1):12. doi: 10.1186/s13046-016-0484-y. PMID: 28086984Free PMC Article
Baselga J, Campone M, Piccart M, Burris HA 3rd, Rugo HS, Sahmoud T, Noguchi S, Gnant M, Pritchard KI, Lebrun F, Beck JT, Ito Y, Yardley D, Deleu I, Perez A, Bachelot T, Vittori L, Xu Z, Mukhopadhyay P, Lebwohl D, Hortobagyi GN
N Engl J Med 2012 Feb 9;366(6):520-9. Epub 2011 Dec 7 doi: 10.1056/NEJMoa1109653. PMID: 22149876Free PMC Article

Recent systematic reviews

Tong J, Ji T, Liu T, Liu J, Chen Y, Li Z, Lu N, Li Q
Epilepsy Behav 2024 Mar;152:109653. Epub 2024 Jan 25 doi: 10.1016/j.yebeh.2024.109653. PMID: 38277848
Wang T, Shen G, Li J, Huo X, Wang M, Liu Z, Zhao F, Ren D, Zhao J
Curr Cancer Drug Targets 2023;23(9):718-730. doi: 10.2174/1568009623666230407101128. PMID: 37026492
Natale P, Palmer SC, Ruospo M, Saglimbene VM, Craig JC, Vecchio M, Samuels JA, Molony DA, Schena FP, Strippoli GF
Cochrane Database Syst Rev 2020 Mar 12;3(3):CD003965. doi: 10.1002/14651858.CD003965.pub3. PMID: 32162319Free PMC Article
Giuliano M, Schettini F, Rognoni C, Milani M, Jerusalem G, Bachelot T, De Laurentiis M, Thomas G, De Placido P, Arpino G, De Placido S, Cristofanilli M, Giordano A, Puglisi F, Pistilli B, Prat A, Del Mastro L, Venturini S, Generali D
Lancet Oncol 2019 Oct;20(10):1360-1369. Epub 2019 Sep 4 doi: 10.1016/S1470-2045(19)30420-6. PMID: 31494037
Statz CM, Patterson SE, Mockus SM
Target Oncol 2017 Feb;12(1):47-59. doi: 10.1007/s11523-016-0453-6. PMID: 27503005

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