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Vascular endothelial growth factor (VEGF) inhibitor response

MedGen UID:
1003819
•Concept ID:
CN322758
•
Sign or Symptom
Synonyms: Vascular Endothelial Growth Factor Inhibitor response; VEGF Inhibitors response
Drug:
Vascular endothelial growth factor (VEGF) inhibitor
MedGen UID:
1778084
•Concept ID:
C4521299
•
Pharmacologic Substance
Vascular endothelial growth factor (VEGF) inhibitor

Professional guidelines

PubMed

Management of Central and Peripheral Nervous System Tumors in Patients with Neurofibromatosis.
Brown R
Curr Oncol Rep 2023 Dec;25(12):1409-1417. Epub 2023 Oct 31 doi: 10.1007/s11912-023-01451-z. PMID: 37906356
First-Line Management of Advanced High-Grade Serous Ovarian Cancer.
Mahmood RD, Morgan RD, Edmondson RJ, Clamp AR, Jayson GC
Curr Oncol Rep 2020 Jun 4;22(6):64. doi: 10.1007/s11912-020-00933-8. PMID: 32494876Free PMC Article
Current management of metastatic renal cell carcinoma: evolving new therapies.
Kumar R, Kapoor A
Curr Opin Support Palliat Care 2017 Sep;11(3):231-237. doi: 10.1097/SPC.0000000000000277. PMID: 28590313

Recent clinical studies

Etiology

Efficacy of Every Four Monthly and Quarterly Dosing of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration: The STAIRWAY Phase 2 Randomized Clinical Trial.
Khanani AM, Patel SS, Ferrone PJ, Osborne A, Sahni J, Grzeschik S, Basu K, Ehrlich JS, Haskova Z, Dugel PU
JAMA Ophthalmol 2020 Sep 1;138(9):964-972. doi: 10.1001/jamaophthalmol.2020.2699. PMID: 32729897Free PMC Article
Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK
Nat Rev Clin Oncol 2018 May;15(5):325-340. Epub 2018 Mar 6 doi: 10.1038/nrclinonc.2018.29. PMID: 29508855Free PMC Article
Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa.
Khan KA, Kerbel RS
Nat Rev Clin Oncol 2018 May;15(5):310-324. Epub 2018 Feb 13 doi: 10.1038/nrclinonc.2018.9. PMID: 29434333
Radiotherapy, chemotherapy and atherosclerosis.
Min SS, Wierzbicki AS
Curr Opin Cardiol 2017 Jul;32(4):441-447. doi: 10.1097/HCO.0000000000000404. PMID: 28306672
Defining response to anti-VEGF therapies in neovascular AMD.
Amoaku WM, Chakravarthy U, Gale R, Gavin M, Ghanchi F, Gibson J, Harding S, Johnston RL, Kelly SP, Lotery A, Mahmood S, Menon G, Sivaprasad S, Talks J, Tufail A, Yang Y
Eye (Lond) 2015 Jun;29(6):721-31. Epub 2015 Apr 17 doi: 10.1038/eye.2015.48. PMID: 25882328Free PMC Article

Diagnosis

Prognostic Biomarkers for Response to Vascular Endothelial Growth Factor-Targeted Therapy for Renal Cell Carcinoma.
Winer AG, Motzer RJ, Hakimi AA
Urol Clin North Am 2016 Feb;43(1):95-104. Epub 2015 Oct 31 doi: 10.1016/j.ucl.2015.08.009. PMID: 26614032Free PMC Article
DIABETIC MACULAR EDEMA.
Musat O, Cernat C, Labib M, Gheorghe A, Toma O, Zamfir M, Boureanu AM
Rom J Ophthalmol 2015 Jul-Sep;59(3):133-6. PMID: 26978879Free PMC Article
VEGF Manipulation in Glioblastoma.
Weathers SP, de Groot J
Oncology (Williston Park) 2015 Oct;29(10):720-7. PMID: 26470893
Defining response to anti-VEGF therapies in neovascular AMD.
Amoaku WM, Chakravarthy U, Gale R, Gavin M, Ghanchi F, Gibson J, Harding S, Johnston RL, Kelly SP, Lotery A, Mahmood S, Menon G, Sivaprasad S, Talks J, Tufail A, Yang Y
Eye (Lond) 2015 Jun;29(6):721-31. Epub 2015 Apr 17 doi: 10.1038/eye.2015.48. PMID: 25882328Free PMC Article
Resistance to antiangiogenic therapies.
Bartolotti M, Franceschi E, Poggi R, Tosoni A, Di Battista M, Brandes AA
Future Oncol 2014 Jun;10(8):1417-25. doi: 10.2217/fon.14.57. PMID: 25052752

Therapy

Molecular mechanism of VEGF and its role in pathological angiogenesis.
Ahmad A, Nawaz MI
J Cell Biochem 2022 Dec;123(12):1938-1965. Epub 2022 Oct 26 doi: 10.1002/jcb.30344. PMID: 36288574
Targeting the HIF2-VEGF axis in renal cell carcinoma.
Choueiri TK, Kaelin WG Jr
Nat Med 2020 Oct;26(10):1519-1530. Epub 2020 Oct 5 doi: 10.1038/s41591-020-1093-z. PMID: 33020645
Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK
Nat Rev Clin Oncol 2018 May;15(5):325-340. Epub 2018 Mar 6 doi: 10.1038/nrclinonc.2018.29. PMID: 29508855Free PMC Article
Defining response to anti-VEGF therapies in neovascular AMD.
Amoaku WM, Chakravarthy U, Gale R, Gavin M, Ghanchi F, Gibson J, Harding S, Johnston RL, Kelly SP, Lotery A, Mahmood S, Menon G, Sivaprasad S, Talks J, Tufail A, Yang Y
Eye (Lond) 2015 Jun;29(6):721-31. Epub 2015 Apr 17 doi: 10.1038/eye.2015.48. PMID: 25882328Free PMC Article
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.
Hicklin DJ, Ellis LM
J Clin Oncol 2005 Feb 10;23(5):1011-27. Epub 2004 Dec 7 doi: 10.1200/JCO.2005.06.081. PMID: 15585754

Prognosis

Persistent diabetic macular edema: Definition, incidence, biomarkers, and treatment methods.
Sorour OA, Levine ES, Baumal CR, Elnahry AG, Braun P, Girgis J, Waheed NK
Surv Ophthalmol 2023 Mar-Apr;68(2):147-174. Epub 2022 Nov 24 doi: 10.1016/j.survophthal.2022.11.008. PMID: 36436614
Vascular endothelial growth factor and programmed death-1 pathway inhibitors in renal cell carcinoma.
Mantia CM, McDermott DF
Cancer 2019 Dec 1;125(23):4148-4157. Epub 2019 Sep 18 doi: 10.1002/cncr.32361. PMID: 31532565Free PMC Article
Prognostic Biomarkers for Response to Vascular Endothelial Growth Factor-Targeted Therapy for Renal Cell Carcinoma.
Winer AG, Motzer RJ, Hakimi AA
Urol Clin North Am 2016 Feb;43(1):95-104. Epub 2015 Oct 31 doi: 10.1016/j.ucl.2015.08.009. PMID: 26614032Free PMC Article
Defining response to anti-VEGF therapies in neovascular AMD.
Amoaku WM, Chakravarthy U, Gale R, Gavin M, Ghanchi F, Gibson J, Harding S, Johnston RL, Kelly SP, Lotery A, Mahmood S, Menon G, Sivaprasad S, Talks J, Tufail A, Yang Y
Eye (Lond) 2015 Jun;29(6):721-31. Epub 2015 Apr 17 doi: 10.1038/eye.2015.48. PMID: 25882328Free PMC Article
Bevacizumab.
Kazazi-Hyseni F, Beijnen JH, Schellens JH
Oncologist 2010;15(8):819-25. Epub 2010 Aug 5 doi: 10.1634/theoncologist.2009-0317. PMID: 20688807Free PMC Article

Clinical prediction guides

Vascular endothelial growth factor and programmed death-1 pathway inhibitors in renal cell carcinoma.
Mantia CM, McDermott DF
Cancer 2019 Dec 1;125(23):4148-4157. Epub 2019 Sep 18 doi: 10.1002/cncr.32361. PMID: 31532565Free PMC Article
Prognostic Biomarkers for Response to Vascular Endothelial Growth Factor-Targeted Therapy for Renal Cell Carcinoma.
Winer AG, Motzer RJ, Hakimi AA
Urol Clin North Am 2016 Feb;43(1):95-104. Epub 2015 Oct 31 doi: 10.1016/j.ucl.2015.08.009. PMID: 26614032Free PMC Article
Defining response to anti-VEGF therapies in neovascular AMD.
Amoaku WM, Chakravarthy U, Gale R, Gavin M, Ghanchi F, Gibson J, Harding S, Johnston RL, Kelly SP, Lotery A, Mahmood S, Menon G, Sivaprasad S, Talks J, Tufail A, Yang Y
Eye (Lond) 2015 Jun;29(6):721-31. Epub 2015 Apr 17 doi: 10.1038/eye.2015.48. PMID: 25882328Free PMC Article
Anti-vascular endothelial growth factor therapy in breast cancer.
Kristensen TB, Knutsson ML, Wehland M, Laursen BE, Grimm D, Warnke E, Magnusson NE
Int J Mol Sci 2014 Dec 11;15(12):23024-41. doi: 10.3390/ijms151223024. PMID: 25514409Free PMC Article
Role of platelet-derived growth factors in physiology and medicine.
Andrae J, Gallini R, Betsholtz C
Genes Dev 2008 May 15;22(10):1276-312. doi: 10.1101/gad.1653708. PMID: 18483217Free PMC Article

Recent systematic reviews

ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR DOSING AND EXPECTED ACUITY OUTCOME AT 1 YEAR.
Spaide RF
Retina 2021 Jun 1;41(6):1153-1163. doi: 10.1097/IAE.0000000000003116. PMID: 33464022
Polymorphisms and endometriosis: a systematic review and meta-analyses.
Méar L, Herr M, Fauconnier A, Pineau C, Vialard F
Hum Reprod Update 2020 Jan 1;26(1):73-102. doi: 10.1093/humupd/dmz034. PMID: 31821471
Anti-vascular endothelial growth factor combined with intravitreal steroids for diabetic macular oedema.
Mehta H, Hennings C, Gillies MC, Nguyen V, Campain A, Fraser-Bell S
Cochrane Database Syst Rev 2018 Apr 18;4(4):CD011599. doi: 10.1002/14651858.CD011599.pub2. PMID: 29669176Free PMC Article
Anti-vascular endothelial growth factor for control of wound healing in glaucoma surgery.
Cheng JW, Cheng SW, Wei RL, Lu GC
Cochrane Database Syst Rev 2016 Jan 15;2016(1):CD009782. doi: 10.1002/14651858.CD009782.pub2. PMID: 26769010Free PMC Article
Vascular-endothelial-growth-factor (VEGF) targeting therapies for endocrine refractory or resistant metastatic breast cancer.
Wagner AD, Thomssen C, Haerting J, Unverzagt S
Cochrane Database Syst Rev 2012 Jul 11;(7):CD008941. doi: 10.1002/14651858.CD008941.pub2. PMID: 22786517

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