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Chlorpropamide response

MedGen UID:
1093727
•Concept ID:
CN427423
•
Sign or Symptom
Drug:
Chlorpropamide
MedGen UID:
40256
•Concept ID:
C0008287
•
Pharmacologic Substance
A long-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to other sulfonylureas, chlorpropamide has an increased risk of prolonged hypoglycemia because of its long half-life. [from NCI]
Chlorpropamide
 
Gene (location): G6PD (Xq28)

Recent clinical studies

Etiology

Evaluation of 2-deoxy-2-[18F]fluoro-D-glucose- and 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography as biomarkers of therapy response in platinum-resistant ovarian cancer.
Perumal M, Stronach EA, Gabra H, Aboagye EO
Mol Imaging Biol 2012 Dec;14(6):753-61. doi: 10.1007/s11307-012-0554-2. PMID: 22484552
Administration of sulfonylureas can increase glucose-induced insulin secretion for decades in patients with maturity-onset diabetes of the young.
Fajans SS, Brown MB
Diabetes Care 1993 Sep;16(9):1254-61. doi: 10.2337/diacare.16.9.1254. PMID: 8404429
Clinical pharmacology of sulfonylureas.
Melander A
Metabolism 1987 Feb;36(2 Suppl 1):12-6. doi: 10.1016/0026-0495(87)90195-8. PMID: 3543616
Effects of oral sulfonylureas on the spectrum of defects in non-insulin-dependent diabetes mellitus.
Owens DR
Am J Med 1985 Aug 23;79(2B):27-32. doi: 10.1016/0002-9343(85)90582-0. PMID: 3929599
Comparison of chlorpropamide and metformin treatment on weight and blood-glucose response of uncontrolled obese diabetics.
Clarke BF, Duncan LJ
Lancet 1968 Jan 20;1(7534):123-6. doi: 10.1016/s0140-6736(68)92726-8. PMID: 4169605

Diagnosis

Evaluation of 2-deoxy-2-[18F]fluoro-D-glucose- and 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography as biomarkers of therapy response in platinum-resistant ovarian cancer.
Perumal M, Stronach EA, Gabra H, Aboagye EO
Mol Imaging Biol 2012 Dec;14(6):753-61. doi: 10.1007/s11307-012-0554-2. PMID: 22484552
Diabetes insipidus in a quadriplegic patient.
Farrell CA, Staas WE Jr
Arch Phys Med Rehabil 1986 Feb;67(2):132-4. doi: 10.1016/0003-9993(86)90126-7. PMID: 3954565
Chlorpropamide alcohol flushing at high chlorpropamide dose is not specific for non-insulin dependent diabetes.
Lipp A, Tang A, Wiles PG
Horm Metab Res 1985 Sep;17(9):480. doi: 10.1055/s-2007-1013581. PMID: 4043928
Acute and chronic effects of sulfonylurea drugs on pancreatic islet function in man.
Pfeifer MA, Halter JB, Judzewitsch RG, Beard JC, Best JD, Ward WK, Porte D Jr
Diabetes Care 1984 May-Jun;7 Suppl 1:25-34. PMID: 6376026
Flushing reactions: consequences and mechanisms.
Wilkin JK
Ann Intern Med 1981 Oct;95(4):468-76. doi: 10.7326/0003-4819-95-4-468. PMID: 6169300

Therapy

Evaluation of 2-deoxy-2-[18F]fluoro-D-glucose- and 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography as biomarkers of therapy response in platinum-resistant ovarian cancer.
Perumal M, Stronach EA, Gabra H, Aboagye EO
Mol Imaging Biol 2012 Dec;14(6):753-61. doi: 10.1007/s11307-012-0554-2. PMID: 22484552
Effects of oral sulfonylureas on the spectrum of defects in non-insulin-dependent diabetes mellitus.
Owens DR
Am J Med 1985 Aug 23;79(2B):27-32. doi: 10.1016/0002-9343(85)90582-0. PMID: 3929599
The chlorpropamide alcohol flush.
Wiles PG, Pyke DA
Clin Sci (Lond) 1984 Oct;67(4):375-81. doi: 10.1042/cs0670375. PMID: 6380892
Flushing reactions: consequences and mechanisms.
Wilkin JK
Ann Intern Med 1981 Oct;95(4):468-76. doi: 10.7326/0003-4819-95-4-468. PMID: 6169300
Response to saluretics and oral antidiabetics in diabetes insipidus and psychic polydipsia.
László FA, Czakó L, Szijj I, Kovács K
Acta Med Acad Sci Hung 1970;27(1):45-55. PMID: 5454558

Prognosis

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer.
Tenbaum SP, Ordóñez-Morán P, Puig I, Chicote I, Arqués O, Landolfi S, Fernández Y, Herance JR, Gispert JD, Mendizabal L, Aguilar S, Ramón y Cajal S, Schwartz S Jr, Vivancos A, Espín E, Rojas S, Baselga J, Tabernero J, Muñoz A, Palmer HG
Nat Med 2012 Jun;18(6):892-901. doi: 10.1038/nm.2772. PMID: 22610277
Administration of sulfonylureas can increase glucose-induced insulin secretion for decades in patients with maturity-onset diabetes of the young.
Fajans SS, Brown MB
Diabetes Care 1993 Sep;16(9):1254-61. doi: 10.2337/diacare.16.9.1254. PMID: 8404429
Alcohol in asthma and the bronchoconstrictor effect of chlorpropamide.
Ayres J, Clark TJ
Br J Dis Chest 1982 Jan;76(1):79-87. PMID: 7059489
Influence of sulfonylureas on the secretion, disposal and effect of insulin.
Almér LO, Johansson E, Melander A, Wåhlin-Boll E
Eur J Clin Pharmacol 1982;22(1):27-32. doi: 10.1007/BF00606421. PMID: 7047169
Clinical evaluation of a new sulfonylurea in maturity onset diabetes - glipizide (K-4024).
Bandisode MS, Boshell BR
Horm Metab Res 1976 Mar;8(2):89-91. PMID: 770300

Clinical prediction guides

Consensus guidelines for oral dosing of primarily renally cleared medications in older adults.
Hanlon JT, Aspinall SL, Semla TP, Weisbord SD, Fried LF, Good CB, Fine MJ, Stone RA, Pugh MJ, Rossi MI, Handler SM
J Am Geriatr Soc 2009 Feb;57(2):335-40. Epub 2008 Dec 10 doi: 10.1111/j.1532-5415.2008.02098.x. PMID: 19170784Free PMC Article
Enzymes that hydrolyze adenine nucleotides in diabetes and associated pathologies.
Lunkes GI, Lunkes D, Stefanello F, Morsch A, Morsch VM, Mazzanti CM, Schetinger MR
Thromb Res 2003 Feb 15;109(4):189-94. doi: 10.1016/s0049-3848(03)00178-6. PMID: 12757773
Effect of magnesium hydroxide on the absorption and efficacy of tolbutamide and chlorpropamide.
Kivistö KT, Neuvonen PJ
Eur J Clin Pharmacol 1992;42(6):675-9. doi: 10.1007/BF00265936. PMID: 1623912
Roles of chlorpropamide, alcohol and acetaldehyde in determining the chlorpropamide-alcohol flush.
Groop L, Eriksson CJ, Huupponen R, Ylikahri R, Pelkonen R
Diabetologia 1984 Jan;26(1):34-8. doi: 10.1007/BF00252260. PMID: 6706043
"Essential" hypernatremia due to ineffective osmotic and intact volume regulation of vasopressin secretion.
DeRubertis FR, Michelis MF, Beck N, Field JB, Davis BB
J Clin Invest 1971 Jan;50(1):97-111. doi: 10.1172/JCI106489. PMID: 5101300Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • CPIC, 2022
      Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.
    • DailyMed Drug Label, 2019
      DailyMed Drug Label, CHLORPROPAMIDE- Discontinued in the US, 2019

    Consumer resources

    Reviews

    Related information

    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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