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Advanced sleep phase syndrome 2(FASPS2)

MedGen UID:
815204
•Concept ID:
C3808874
•
Disease or Syndrome
Synonym: Advanced sleep phase syndrome, familial, 2
 
Gene (location): CSNK1D (17q25.3)
 
Monarch Initiative: MONDO:0014088
OMIM®: 615224

Definition

Advanced sleep phase syndrome is characterized by very early sleep onset and offset (summary by Jones et al., 1999). For a discussion of genetic heterogeneity of advanced sleep phase syndrome, see FASPS1 (604348). [from OMIM]

Clinical features

From HPO
Migraine
MedGen UID:
57451
•Concept ID:
C0149931
•
Disease or Syndrome
Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms.
See: Feature record | Search on this feature
Migraine with aura
MedGen UID:
57822
•Concept ID:
C0154723
•
Disease or Syndrome
A type of migraine in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession.
See: Feature record | Search on this feature
Migraine without aura
MedGen UID:
137899
•Concept ID:
C0338480
•
Disease or Syndrome
Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria
See: Feature record | Search on this feature
Circadian rhythm sleep disorder
MedGen UID:
167920
•Concept ID:
C0877792
•
Pathologic Function
Any abnormality of an individual's circadian rhythm that affects the timing of sleeping and being awake is referred to as a sleep-wake disorder.
See: Feature record | Search on this feature
Early chronotype
MedGen UID:
1646349
•Concept ID:
C4703587
•
Finding
A tendency towards rising very early in the morning and going to bed early in the evening.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Insomnia in neurological disorders: Prevalence, mechanisms, impact and treatment approaches.
de Bergeyck R, Geoffroy PA
Rev Neurol (Paris) 2023 Oct;179(7):767-781. Epub 2023 Aug 22 doi: 10.1016/j.neurol.2023.08.008. PMID: 37620177
Clinical management of jet lag: what can be proposed when performance is critical?
Coste O, Lagarde D
Travel Med Infect Dis 2009 Mar;7(2):82-7. Epub 2008 Nov 7 doi: 10.1016/j.tmaid.2008.08.004. PMID: 19237141
Melatonin for the prevention and treatment of jet lag.
Herxheimer A, Petrie KJ
Cochrane Database Syst Rev 2002;(2):CD001520. doi: 10.1002/14651858.CD001520. PMID: 12076414

Recent clinical studies

Etiology

Interconnection between circadian clocks and thyroid function.
Ikegami K, Refetoff S, Van Cauter E, Yoshimura T
Nat Rev Endocrinol 2019 Oct;15(10):590-600. Epub 2019 Aug 12 doi: 10.1038/s41574-019-0237-z. PMID: 31406343Free PMC Article
The Circadian Syndrome: is the Metabolic Syndrome and much more!
Zimmet P, Alberti KGMM, Stern N, Bilu C, El-Osta A, Einat H, Kronfeld-Schor N
J Intern Med 2019 Aug;286(2):181-191. Epub 2019 Jun 10 doi: 10.1111/joim.12924. PMID: 31081577Free PMC Article
Working against the biological clock: a review for the Occupational Physician.
Copertaro A, Bracci M
Ind Health 2019 Sep 26;57(5):557-569. Epub 2019 Feb 22 doi: 10.2486/indhealth.2018-0173. PMID: 30799323Free PMC Article
Impacts of shift work on sleep and circadian rhythms.
Boivin DB, Boudreau P
Pathol Biol (Paris) 2014 Oct;62(5):292-301. Epub 2014 Sep 20 doi: 10.1016/j.patbio.2014.08.001. PMID: 25246026
Excessive sleepiness.
Tsai SC
Clin Chest Med 2010 Jun;31(2):341-51. doi: 10.1016/j.ccm.2010.02.007. PMID: 20488292

Diagnosis

Circadian Rhythm Sleep-Wake Disorders in Older Adults.
Kim JH, Elkhadem AR, Duffy JF
Sleep Med Clin 2022 Jun;17(2):241-252. doi: 10.1016/j.jsmc.2022.02.003. PMID: 35659077Free PMC Article
Telemedicine in Pediatric Sleep.
Paruthi S
Sleep Med Clin 2020 Sep;15(3S):e1-e7. Epub 2020 Sep 3 doi: 10.1016/j.jsmc.2020.07.003. PMID: 33008491Free PMC Article
Jet lag modification.
Simmons E, McGrane O, Wedmore I
Curr Sports Med Rep 2015 Mar-Apr;14(2):123-8. doi: 10.1249/JSR.0000000000000133. PMID: 25757008
International classification of sleep disorders-third edition: highlights and modifications.
Sateia MJ
Chest 2014 Nov;146(5):1387-1394. doi: 10.1378/chest.14-0970. PMID: 25367475
Sleep patterns and predictors of disturbed sleep in a large population of college students.
Lund HG, Reider BD, Whiting AB, Prichard JR
J Adolesc Health 2010 Feb;46(2):124-32. Epub 2009 Aug 3 doi: 10.1016/j.jadohealth.2009.06.016. PMID: 20113918

Therapy

Circadian Biology and Stroke.
Lo EH, Albers GW, Dichgans M, Donnan G, Esposito E, Foster R, Howells DW, Huang YG, Ji X, Klerman EB, Lee S, Li W, Liebeskind DS, Lizasoain I, Mandeville ET, Moro MA, Ning M, Ray D, Sakadžić S, Saver JL, Scheer FAJL, Selim M, Tiedt S, Zhang F, Buchan AM
Stroke 2021 Jun;52(6):2180-2190. Epub 2021 May 4 doi: 10.1161/STROKEAHA.120.031742. PMID: 33940951
British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update.
Wilson S, Anderson K, Baldwin D, Dijk DJ, Espie A, Espie C, Gringras P, Krystal A, Nutt D, Selsick H, Sharpley A
J Psychopharmacol 2019 Aug;33(8):923-947. Epub 2019 Jul 4 doi: 10.1177/0269881119855343. PMID: 31271339
Circadian regulation of metabolism.
Bailey SM, Udoh US, Young ME
J Endocrinol 2014 Aug;222(2):R75-96. Epub 2014 Jun 13 doi: 10.1530/JOE-14-0200. PMID: 24928941Free PMC Article
Circadian rhythms, sleep, and metabolism.
Huang W, Ramsey KM, Marcheva B, Bass J
J Clin Invest 2011 Jun;121(6):2133-41. Epub 2011 Jun 1 doi: 10.1172/JCI46043. PMID: 21633182Free PMC Article
The pathophysiology of jet lag.
Sack RL
Travel Med Infect Dis 2009 Mar;7(2):102-10. Epub 2009 Feb 14 doi: 10.1016/j.tmaid.2009.01.006. PMID: 19237143

Prognosis

Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease.
Rigat L, Ouk K, Kramer A, Priller J
Acta Physiol (Oxf) 2023 Jun;238(2):e13970. Epub 2023 Apr 18 doi: 10.1111/apha.13970. PMID: 37000425
Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study.
Richmond RC, Anderson EL, Dashti HS, Jones SE, Lane JM, Strand LB, Brumpton B, Rutter MK, Wood AR, Straif K, Relton CL, Munafò M, Frayling TM, Martin RM, Saxena R, Weedon MN, Lawlor DA, Smith GD
BMJ 2019 Jun 26;365:l2327. doi: 10.1136/bmj.l2327. PMID: 31243001Free PMC Article
Sleep Regulation, Physiology and Development, Sleep Duration and Patterns, and Sleep Hygiene in Infants, Toddlers, and Preschool-Age Children.
Bathory E, Tomopoulos S
Curr Probl Pediatr Adolesc Health Care 2017 Feb;47(2):29-42. Epub 2017 Jan 20 doi: 10.1016/j.cppeds.2016.12.001. PMID: 28117135
Impacts of shift work on sleep and circadian rhythms.
Boivin DB, Boudreau P
Pathol Biol (Paris) 2014 Oct;62(5):292-301. Epub 2014 Sep 20 doi: 10.1016/j.patbio.2014.08.001. PMID: 25246026
Sleep patterns and predictors of disturbed sleep in a large population of college students.
Lund HG, Reider BD, Whiting AB, Prichard JR
J Adolesc Health 2010 Feb;46(2):124-32. Epub 2009 Aug 3 doi: 10.1016/j.jadohealth.2009.06.016. PMID: 20113918

Clinical prediction guides

Sleep disorders in people with type 2 diabetes and associated health outcomes: a review of the literature.
Schipper SBJ, Van Veen MM, Elders PJM, van Straten A, Van Der Werf YD, Knutson KL, Rutters F
Diabetologia 2021 Nov;64(11):2367-2377. Epub 2021 Aug 16 doi: 10.1007/s00125-021-05541-0. PMID: 34401953Free PMC Article
Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing.
Phillips AJK, Clerx WM, O'Brien CS, Sano A, Barger LK, Picard RW, Lockley SW, Klerman EB, Czeisler CA
Sci Rep 2017 Jun 12;7(1):3216. doi: 10.1038/s41598-017-03171-4. PMID: 28607474Free PMC Article
Impacts of shift work on sleep and circadian rhythms.
Boivin DB, Boudreau P
Pathol Biol (Paris) 2014 Oct;62(5):292-301. Epub 2014 Sep 20 doi: 10.1016/j.patbio.2014.08.001. PMID: 25246026
Circadian rhythms, sleep, and metabolism.
Huang W, Ramsey KM, Marcheva B, Bass J
J Clin Invest 2011 Jun;121(6):2133-41. Epub 2011 Jun 1 doi: 10.1172/JCI46043. PMID: 21633182Free PMC Article
Sleep patterns and predictors of disturbed sleep in a large population of college students.
Lund HG, Reider BD, Whiting AB, Prichard JR
J Adolesc Health 2010 Feb;46(2):124-32. Epub 2009 Aug 3 doi: 10.1016/j.jadohealth.2009.06.016. PMID: 20113918

Recent systematic reviews

Social jetlag and obesity: A systematic review and meta-analysis.
Arab A, Karimi E, Garaulet M, Scheer FAJL
Obes Rev 2024 Mar;25(3):e13664. Epub 2023 Dec 10 doi: 10.1111/obr.13664. PMID: 38072635
Circadian preference and mental health outcomes in youth: A systematic review and meta-analysis.
Cheung FTW, Li X, Hui TK, Chan NY, Chan JW, Wing YK, Li SX
Sleep Med Rev 2023 Dec;72:101851. Epub 2023 Sep 17 doi: 10.1016/j.smrv.2023.101851. PMID: 37793219
Shift Work and Poor Mental Health: A Meta-Analysis of Longitudinal Studies.
Torquati L, Mielke GI, Brown WJ, Burton NW, Kolbe-Alexander TL
Am J Public Health 2019 Nov;109(11):e13-e20. Epub 2019 Sep 19 doi: 10.2105/AJPH.2019.305278. PMID: 31536404Free PMC Article
British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update.
Wilson S, Anderson K, Baldwin D, Dijk DJ, Espie A, Espie C, Gringras P, Krystal A, Nutt D, Selsick H, Sharpley A
J Psychopharmacol 2019 Aug;33(8):923-947. Epub 2019 Jul 4 doi: 10.1177/0269881119855343. PMID: 31271339
Melatonin for the prevention and treatment of jet lag.
Herxheimer A, Petrie KJ
Cochrane Database Syst Rev 2002;(2):CD001520. doi: 10.1002/14651858.CD001520. PMID: 12076414

Supplemental Content

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      Clinical tests in GTR
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      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
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