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Leukemia, Philadelphia chromosome-positive, resistant to imatinib

MedGen UID:
864833
•Concept ID:
C4016396
•
Finding
Synonym: LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB
 
OMIM®: 189980

Professional guidelines

PubMed

Targeting BCR-Abl in the treatment of Philadelphia-chromosome positive chronic myelogenous leukemia.
Roskoski R Jr
Pharmacol Res 2022 Apr;178:106156. Epub 2022 Mar 4 doi: 10.1016/j.phrs.2022.106156. PMID: 35257901
New Treatment Strategies for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.
Saini L, Brandwein J
Curr Hematol Malig Rep 2017 Apr;12(2):136-142. doi: 10.1007/s11899-017-0372-3. PMID: 28243848
Current and future management of Ph/BCR-ABL positive ALL.
Maino E, Sancetta R, Viero P, Imbergamo S, Scattolin AM, Vespignani M, Bassan R
Expert Rev Anticancer Ther 2014 Jun;14(6):723-40. Epub 2014 Mar 10 doi: 10.1586/14737140.2014.895669. PMID: 24611626

Recent clinical studies

Etiology

Ponatinib vs Imatinib in Frontline Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Jabbour E, Kantarjian HM, Aldoss I, Montesinos P, Leonard JT, Gómez-Almaguer D, Baer MR, Gambacorti-Passerini C, McCloskey J, Minami Y, Papayannidis C, Rocha V, Rousselot P, Vachhani P, Wang ES, Wang B, Hennessy M, Vorog A, Patel N, Yeh T, Ribera JM
JAMA 2024 Jun 4;331(21):1814-1823. doi: 10.1001/jama.2024.4783. PMID: 38722621Free PMC Article
Dasatinib Plus Intensive Chemotherapy in Children, Adolescents, and Young Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of Children's Oncology Group Trial AALL0622.
Slayton WB, Schultz KR, Kairalla JA, Devidas M, Mi X, Pulsipher MA, Chang BH, Mullighan C, Iacobucci I, Silverman LB, Borowitz MJ, Carroll AJ, Heerema NA, Gastier-Foster JM, Wood BL, Mizrahy SL, Merchant T, Brown VI, Sieger L, Siegel MJ, Raetz EA, Winick NJ, Loh ML, Carroll WL, Hunger SP
J Clin Oncol 2018 Aug 1;36(22):2306-2314. Epub 2018 May 29 doi: 10.1200/JCO.2017.76.7228. PMID: 29812996Free PMC Article
Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: current treatments and future perspectives.
Yilmaz M, Kantarjian H, Ravandi-Kashani F, Short NJ, Jabbour E
Clin Adv Hematol Oncol 2018 Mar;16(3):216-223. PMID: 29742077
New Treatment Strategies for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.
Saini L, Brandwein J
Curr Hematol Malig Rep 2017 Apr;12(2):136-142. doi: 10.1007/s11899-017-0372-3. PMID: 28243848
Dasatinib.
Lindauer M, Hochhaus A
Recent Results Cancer Res 2010;184:83-102. doi: 10.1007/978-3-642-01222-8_7. PMID: 20072833

Diagnosis

Ponatinib vs Imatinib in Frontline Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Jabbour E, Kantarjian HM, Aldoss I, Montesinos P, Leonard JT, Gómez-Almaguer D, Baer MR, Gambacorti-Passerini C, McCloskey J, Minami Y, Papayannidis C, Rocha V, Rousselot P, Vachhani P, Wang ES, Wang B, Hennessy M, Vorog A, Patel N, Yeh T, Ribera JM
JAMA 2024 Jun 4;331(21):1814-1823. doi: 10.1001/jama.2024.4783. PMID: 38722621Free PMC Article
Dasatinib Plus Intensive Chemotherapy in Children, Adolescents, and Young Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of Children's Oncology Group Trial AALL0622.
Slayton WB, Schultz KR, Kairalla JA, Devidas M, Mi X, Pulsipher MA, Chang BH, Mullighan C, Iacobucci I, Silverman LB, Borowitz MJ, Carroll AJ, Heerema NA, Gastier-Foster JM, Wood BL, Mizrahy SL, Merchant T, Brown VI, Sieger L, Siegel MJ, Raetz EA, Winick NJ, Loh ML, Carroll WL, Hunger SP
J Clin Oncol 2018 Aug 1;36(22):2306-2314. Epub 2018 May 29 doi: 10.1200/JCO.2017.76.7228. PMID: 29812996Free PMC Article
Bosutinib Versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia: Results From the Randomized BFORE Trial.
Cortes JE, Gambacorti-Passerini C, Deininger MW, Mauro MJ, Chuah C, Kim DW, Dyagil I, Glushko N, Milojkovic D, le Coutre P, Garcia-Gutierrez V, Reilly L, Jeynes-Ellis A, Leip E, Bardy-Bouxin N, Hochhaus A, Brümmendorf TH
J Clin Oncol 2018 Jan 20;36(3):231-237. Epub 2017 Nov 1 doi: 10.1200/JCO.2017.74.7162. PMID: 29091516Free PMC Article
Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
Foà R, Vitale A, Vignetti M, Meloni G, Guarini A, De Propris MS, Elia L, Paoloni F, Fazi P, Cimino G, Nobile F, Ferrara F, Castagnola C, Sica S, Leoni P, Zuffa E, Fozza C, Luppi M, Candoni A, Iacobucci I, Soverini S, Mandelli F, Martinelli G, Baccarani M; GIMEMA Acute Leukemia Working Party
Blood 2011 Dec 15;118(25):6521-8. Epub 2011 Sep 19 doi: 10.1182/blood-2011-05-351403. PMID: 21931113
First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia.
Ravandi F, O'Brien S, Thomas D, Faderl S, Jones D, Garris R, Dara S, Jorgensen J, Kebriaei P, Champlin R, Borthakur G, Burger J, Ferrajoli A, Garcia-Manero G, Wierda W, Cortes J, Kantarjian H
Blood 2010 Sep 23;116(12):2070-7. Epub 2010 May 13 doi: 10.1182/blood-2009-12-261586. PMID: 20466853Free PMC Article

Therapy

Ponatinib vs Imatinib in Frontline Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Jabbour E, Kantarjian HM, Aldoss I, Montesinos P, Leonard JT, Gómez-Almaguer D, Baer MR, Gambacorti-Passerini C, McCloskey J, Minami Y, Papayannidis C, Rocha V, Rousselot P, Vachhani P, Wang ES, Wang B, Hennessy M, Vorog A, Patel N, Yeh T, Ribera JM
JAMA 2024 Jun 4;331(21):1814-1823. doi: 10.1001/jama.2024.4783. PMID: 38722621Free PMC Article
Dasatinib.
Lindauer M, Hochhaus A
Recent Results Cancer Res 2018;212:29-68. doi: 10.1007/978-3-319-91439-8_2. PMID: 30069624
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR
Nature 2017 Mar 30;543(7647):733-737. Epub 2017 Mar 22 doi: 10.1038/nature21702. PMID: 28329763
Nilotinib.
Ostendorf BN, le Coutre P, Kim TD, Quintás-Cardama A
Recent Results Cancer Res 2014;201:67-80. doi: 10.1007/978-3-642-54490-3_3. PMID: 24756785
Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
Foà R, Vitale A, Vignetti M, Meloni G, Guarini A, De Propris MS, Elia L, Paoloni F, Fazi P, Cimino G, Nobile F, Ferrara F, Castagnola C, Sica S, Leoni P, Zuffa E, Fozza C, Luppi M, Candoni A, Iacobucci I, Soverini S, Mandelli F, Martinelli G, Baccarani M; GIMEMA Acute Leukemia Working Party
Blood 2011 Dec 15;118(25):6521-8. Epub 2011 Sep 19 doi: 10.1182/blood-2011-05-351403. PMID: 21931113

Prognosis

Dasatinib Plus Intensive Chemotherapy in Children, Adolescents, and Young Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of Children's Oncology Group Trial AALL0622.
Slayton WB, Schultz KR, Kairalla JA, Devidas M, Mi X, Pulsipher MA, Chang BH, Mullighan C, Iacobucci I, Silverman LB, Borowitz MJ, Carroll AJ, Heerema NA, Gastier-Foster JM, Wood BL, Mizrahy SL, Merchant T, Brown VI, Sieger L, Siegel MJ, Raetz EA, Winick NJ, Loh ML, Carroll WL, Hunger SP
J Clin Oncol 2018 Aug 1;36(22):2306-2314. Epub 2018 May 29 doi: 10.1200/JCO.2017.76.7228. PMID: 29812996Free PMC Article
Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: current treatments and future perspectives.
Yilmaz M, Kantarjian H, Ravandi-Kashani F, Short NJ, Jabbour E
Clin Adv Hematol Oncol 2018 Mar;16(3):216-223. PMID: 29742077
Managing Philadelphia chromosome-positive acute lymphoblastic leukemia: role of tyrosine kinase inhibitors.
Ravandi F
Clin Lymphoma Myeloma Leuk 2011 Apr;11(2):198-203. Epub 2011 Apr 8 doi: 10.1016/j.clml.2011.03.002. PMID: 21575924Free PMC Article
Philadelphia chromosome-positive acute lymphoblastic leukemia: current treatment and future perspectives.
Lee HJ, Thompson JE, Wang ES, Wetzler M
Cancer 2011 Apr 15;117(8):1583-94. Epub 2010 Nov 8 doi: 10.1002/cncr.25690. PMID: 21472706
Dasatinib.
Lindauer M, Hochhaus A
Recent Results Cancer Res 2010;184:83-102. doi: 10.1007/978-3-642-01222-8_7. PMID: 20072833

Clinical prediction guides

The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR
Nature 2017 Mar 30;543(7647):733-737. Epub 2017 Mar 22 doi: 10.1038/nature21702. PMID: 28329763
Dasatinib.
Korashy HM, Rahman AF, Kassem MG
Profiles Drug Subst Excip Relat Methodol 2014;39:205-37. doi: 10.1016/B978-0-12-800173-8.00004-0. PMID: 24794907
Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
Foà R, Vitale A, Vignetti M, Meloni G, Guarini A, De Propris MS, Elia L, Paoloni F, Fazi P, Cimino G, Nobile F, Ferrara F, Castagnola C, Sica S, Leoni P, Zuffa E, Fozza C, Luppi M, Candoni A, Iacobucci I, Soverini S, Mandelli F, Martinelli G, Baccarani M; GIMEMA Acute Leukemia Working Party
Blood 2011 Dec 15;118(25):6521-8. Epub 2011 Sep 19 doi: 10.1182/blood-2011-05-351403. PMID: 21931113
New approaches to the management of Philadelphia-chromosome-positive acute lymphocytic leukemia.
Thomas DA, O'Brien S, Cortes J, Kantarjian H
Curr Hematol Malig Rep 2007 Jul;2(3):183-9. doi: 10.1007/s11899-007-0025-z. PMID: 20425368
Dasatinib.
Shah NP
Drugs Today (Barc) 2007 Jan;43(1):5-12. doi: 10.1358/dot.2007.43.1.1050791. PMID: 17315048

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