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Cleft lip/palate

MedGen UID:
57640
•Concept ID:
C0158646
•
Congenital Abnormality; Finding
Synonym: Cleft lip and palate
SNOMED CT: Cleft palate with cleft lip (66948001); Cleft palate and lip (66948001)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0016044
Orphanet: ORPHA199306

Definition

Cleft lip and palate is a fissure type embryopathy extending across the upper lip, nasal base, alveolar ridge and the hard and soft palate. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCleft lip/palate

Professional guidelines

PubMed

Parental anxiety/incompliance and patients' complications during COVID-19 pandemic regarding nasoalveolar molding treatment of infants with cleft lip/palate.
Sarmadi S, Shahroudi AS, Mohammadi F, Shamshiri AR, Safari F
Cleft Palate Craniofac J 2024 Jun;61(6):1033-1040. Epub 2023 Jan 26 doi: 10.1177/10556656231153026. PMID: 36703258Free PMC Article
Cleft Lip and Palate Midfacial Hypoplasia: Criteria to Choose the Treatment.
Fariña R, Lolas J, Moreno E, Alister JP, Uribe MF, Pantoja R, Valladares S, Arrué C
J Craniofac Surg 2022 Mar-Apr 01;33(2):496-501. doi: 10.1097/SCS.0000000000007973. PMID: 34261964
Global Nursing in Low-Resource and Middle-Resource Countries: Challenges and Opportunities in Perioperative Practice.
Pettorini K, Gullatte MM
Oral Maxillofac Surg Clin North Am 2020 Aug;32(3):437-445. Epub 2020 Jun 2 doi: 10.1016/j.coms.2020.04.009. PMID: 32507356

Recent clinical studies

Etiology

Antibiotic prophylaxis in oral and maxillofacial surgery: a systematic review.
Milic T, Raidoo P, Gebauer D
Br J Oral Maxillofac Surg 2021 Jul;59(6):633-642. Epub 2020 Sep 23 doi: 10.1016/j.bjoms.2020.09.020. PMID: 34016464
Ocular manifestations of ectodermal dysplasia.
Landau Prat D, Katowitz WR, Strong A, Katowitz JA
Orphanet J Rare Dis 2021 May 1;16(1):197. doi: 10.1186/s13023-021-01824-2. PMID: 33933124Free PMC Article
Evaluation of the Facial Soft-Tissue Thickness in Patients With Cleft Lip and Palate.
Erdur EA, Baka ZM, Fidanboy M, Erdur O
J Craniofac Surg 2019 Sep;30(6):1706-1709. doi: 10.1097/SCS.0000000000005504. PMID: 31033758
Acro-cardio-facial syndrome.
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article
The pediatric neurotransmitter disorders.
Pearl PL, Taylor JL, Trzcinski S, Sokohl A
J Child Neurol 2007 May;22(5):606-16. doi: 10.1177/0883073807302619. PMID: 17690069

Diagnosis

Oral management of children/adolescents with ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome: A scoping review.
Garrocho-Rangel A, Serrano-Aguilar G, Hernández-Molinar Y, Aranda-Romo S, Alejandri-Gamboa V, Pozos-Guillén A
Spec Care Dentist 2023 Mar;43(2):152-162. Epub 2022 Jul 25 doi: 10.1111/scd.12752. PMID: 35879828
The Molecular Basis of Congenital Hypopituitarism and Related Disorders.
Gregory LC, Dattani MT
J Clin Endocrinol Metab 2020 Jun 1;105(6) doi: 10.1210/clinem/dgz184. PMID: 31702014
Acro-cardio-facial syndrome.
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article
The pediatric neurotransmitter disorders.
Pearl PL, Taylor JL, Trzcinski S, Sokohl A
J Child Neurol 2007 May;22(5):606-16. doi: 10.1177/0883073807302619. PMID: 17690069
Holoprosencephaly.
Dubourg C, Bendavid C, Pasquier L, Henry C, Odent S, David V
Orphanet J Rare Dis 2007 Feb 2;2:8. doi: 10.1186/1750-1172-2-8. PMID: 17274816Free PMC Article

Therapy

Antibiotic prophylaxis in oral and maxillofacial surgery: a systematic review.
Milic T, Raidoo P, Gebauer D
Br J Oral Maxillofac Surg 2021 Jul;59(6):633-642. Epub 2020 Sep 23 doi: 10.1016/j.bjoms.2020.09.020. PMID: 34016464
Biomaterials for Cleft Lip and Palate Regeneration.
Martín-Del-Campo M, Rosales-Ibañez R, Rojo L
Int J Mol Sci 2019 May 2;20(9) doi: 10.3390/ijms20092176. PMID: 31052503Free PMC Article
Manifestations of Gorlin-Goltz syndrome.
Larsen AK, Mikkelsen DB, Hertz JM, Bygum A
Dan Med J 2014 May;61(5):A4829. PMID: 24814739
The importance of monotherapy in pregnancy.
Pennell PB
Neurology 2003 Jun 10;60(11 Suppl 4):S31-8. doi: 10.1212/wnl.60.11_suppl_4.s31. PMID: 12796519
Schisis-association.
Czeizel A
Am J Med Genet 1981;10(1):25-35. doi: 10.1002/ajmg.1320100105. PMID: 7294060

Prognosis

Three-dimensional planning accuracy and follow-up of Le Fort I osteotomy in cleft lip/palate patients.
Nys M, Bempt MVD, Shaheen E, Dormaar JT, Politis C
J Stomatol Oral Maxillofac Surg 2023 Sep;124(4):101421. Epub 2023 Feb 9 doi: 10.1016/j.jormas.2023.101421. PMID: 36764580
The Molecular Basis of Congenital Hypopituitarism and Related Disorders.
Gregory LC, Dattani MT
J Clin Endocrinol Metab 2020 Jun 1;105(6) doi: 10.1210/clinem/dgz184. PMID: 31702014
Manifestations of Gorlin-Goltz syndrome.
Larsen AK, Mikkelsen DB, Hertz JM, Bygum A
Dan Med J 2014 May;61(5):A4829. PMID: 24814739
Acro-cardio-facial syndrome.
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article
Holoprosencephaly.
Dubourg C, Bendavid C, Pasquier L, Henry C, Odent S, David V
Orphanet J Rare Dis 2007 Feb 2;2:8. doi: 10.1186/1750-1172-2-8. PMID: 17274816Free PMC Article

Clinical prediction guides

Oral management of children/adolescents with ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome: A scoping review.
Garrocho-Rangel A, Serrano-Aguilar G, Hernández-Molinar Y, Aranda-Romo S, Alejandri-Gamboa V, Pozos-Guillén A
Spec Care Dentist 2023 Mar;43(2):152-162. Epub 2022 Jul 25 doi: 10.1111/scd.12752. PMID: 35879828
p63 in corneal and epidermal differentiation.
Novelli F, Ganini C, Melino G, Nucci C, Han Y, Shi Y, Wang Y, Candi E
Biochem Biophys Res Commun 2022 Jun 25;610:15-22. Epub 2022 Apr 9 doi: 10.1016/j.bbrc.2022.04.022. PMID: 35430447
Global Birth Prevalence of Orofacial Clefts: A Systematic Review.
Panamonta V, Pradubwong S, Panamonta M, Chowchuen B
J Med Assoc Thai 2015 Aug;98 Suppl 7:S11-21. PMID: 26742364
Holoprosencephaly.
Dubourg C, Bendavid C, Pasquier L, Henry C, Odent S, David V
Orphanet J Rare Dis 2007 Feb 2;2:8. doi: 10.1186/1750-1172-2-8. PMID: 17274816Free PMC Article
The telecanthus-hypospadias syndrome.
Stevens CA, Wilroy RS Jr
J Med Genet 1988 Aug;25(8):536-42. doi: 10.1136/jmg.25.8.536. PMID: 3050099Free PMC Article

Recent systematic reviews

Antibiotic prophylaxis in oral and maxillofacial surgery: a systematic review.
Milic T, Raidoo P, Gebauer D
Br J Oral Maxillofac Surg 2021 Jul;59(6):633-642. Epub 2020 Sep 23 doi: 10.1016/j.bjoms.2020.09.020. PMID: 34016464
Polymorphic Variants of V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog B (rs13041247 and rs11696257) and Risk of Non-Syndromic Cleft Lip/Palate: Systematic Review and Meta-Analysis.
Imani MM, Lopez-Jornet P, Pons-Fuster López E, Sadeghi M
Int J Environ Res Public Health 2019 Aug 5;16(15) doi: 10.3390/ijerph16152792. PMID: 31387249Free PMC Article
Polymorphism of reduced folate carrier 1 (A80G) and non-syndromic cleft lip/palate: A systematic review and meta-analysis.
Imani MM, Mozaffari HR, Sharifi R, Sadeghi M
Arch Oral Biol 2019 Feb;98:273-279. Epub 2018 Dec 11 doi: 10.1016/j.archoralbio.2018.12.005. PMID: 30579244
A Systematic Review of the Use of Telemedicine in Plastic and Reconstructive Surgery and Dermatology.
Vyas KS, Hambrick HR, Shakir A, Morrison SD, Tran DC, Pearson K, Vasconez HC, Mardini S, Gosman AA, Dobke M, Granick MS
Ann Plast Surg 2017 Jun;78(6):736-768. doi: 10.1097/SAP.0000000000001044. PMID: 28328635
Global Birth Prevalence of Orofacial Clefts: A Systematic Review.
Panamonta V, Pradubwong S, Panamonta M, Chowchuen B
J Med Assoc Thai 2015 Aug;98 Suppl 7:S11-21. PMID: 26742364

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