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Oligoastrocytoma

MedGen UID:
154285
•Concept ID:
C0547065
•
Neoplastic Process
Synonyms: Mixed Oligoastrocytoma; Mixed Oligoastrocytomas; Oligoastrocytoma, Mixed
SNOMED CT: Mixed oligoastrocytoma (716647001); Mixed oligoastrocytoma (253071005)
 
Monarch Initiative: MONDO:0016702
Orphanet: ORPHA251656

Definition

Oligoastrocytoma is a type of low-grade glioma with a mixed astrocytoma and oligodendroglioma histology, manifesting with headaches, speech and motor problems, seizures and, in some, subarachnoid haemorrhage. [from ORDO]

Professional guidelines

PubMed

Treatment Outcomes in 1p19q Co-deleted/Partially Deleted Gliomas.
McNamara MG, Jiang H, Lim-Fat MJ, Sahebjam S, Kiehl TR, Karamchandani J, Coire C, Chung C, Millar BA, Laperriere N, Mason WP
Can J Neurol Sci 2017 May;44(3):288-294. doi: 10.1017/cjn.2016.420. PMID: 28488951
Anaplastic glioma: current treatment and management.
Le Rhun E, Taillibert S, Chamberlain MC
Expert Rev Neurother 2015 Jun;15(6):601-20. Epub 2015 May 2 doi: 10.1586/14737175.2015.1042455. PMID: 25936680
The potential for genetically altered microglia to influence glioma treatment.
Li W, Holsinger RM, Kruse CA, Flügel A, Graeber MB
CNS Neurol Disord Drug Targets 2013 Sep;12(6):750-62. doi: 10.2174/18715273113126660171. PMID: 24047526Free PMC Article

Recent clinical studies

Etiology

WHO 2016 Classification of gliomas.
Wesseling P, Capper D
Neuropathol Appl Neurobiol 2018 Feb;44(2):139-150. doi: 10.1111/nan.12432. PMID: 28815663
Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma.
Buckner JC, Shaw EG, Pugh SL, Chakravarti A, Gilbert MR, Barger GR, Coons S, Ricci P, Bullard D, Brown PD, Stelzer K, Brachman D, Suh JH, Schultz CJ, Bahary JP, Fisher BJ, Kim H, Murtha AD, Bell EH, Won M, Mehta MP, Curran WJ Jr
N Engl J Med 2016 Apr 7;374(14):1344-55. doi: 10.1056/NEJMoa1500925. PMID: 27050206Free PMC Article
Chemotherapy in glioma.
Taal W, Bromberg JE, van den Bent MJ
CNS Oncol 2015;4(3):179-92. Epub 2015 Apr 23 doi: 10.2217/cns.15.2. PMID: 25906059Free PMC Article
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Diagnosis

WHO 2016 Classification of gliomas.
Wesseling P, Capper D
Neuropathol Appl Neurobiol 2018 Feb;44(2):139-150. doi: 10.1111/nan.12432. PMID: 28815663
Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma.
Buckner JC, Shaw EG, Pugh SL, Chakravarti A, Gilbert MR, Barger GR, Coons S, Ricci P, Bullard D, Brown PD, Stelzer K, Brachman D, Suh JH, Schultz CJ, Bahary JP, Fisher BJ, Kim H, Murtha AD, Bell EH, Won M, Mehta MP, Curran WJ Jr
N Engl J Med 2016 Apr 7;374(14):1344-55. doi: 10.1056/NEJMoa1500925. PMID: 27050206Free PMC Article
Low-grade and anaplastic oligodendroglioma.
Van Den Bent MJ, Bromberg JE, Buckner J
Handb Clin Neurol 2016;134:361-80. doi: 10.1016/B978-0-12-802997-8.00022-0. PMID: 26948366
Chemotherapy in glioma.
Taal W, Bromberg JE, van den Bent MJ
CNS Oncol 2015;4(3):179-92. Epub 2015 Apr 23 doi: 10.2217/cns.15.2. PMID: 25906059Free PMC Article
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082

Therapy

Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma.
Buckner JC, Shaw EG, Pugh SL, Chakravarti A, Gilbert MR, Barger GR, Coons S, Ricci P, Bullard D, Brown PD, Stelzer K, Brachman D, Suh JH, Schultz CJ, Bahary JP, Fisher BJ, Kim H, Murtha AD, Bell EH, Won M, Mehta MP, Curran WJ Jr
N Engl J Med 2016 Apr 7;374(14):1344-55. doi: 10.1056/NEJMoa1500925. PMID: 27050206Free PMC Article
Low-grade and anaplastic oligodendroglioma.
Van Den Bent MJ, Bromberg JE, Buckner J
Handb Clin Neurol 2016;134:361-80. doi: 10.1016/B978-0-12-802997-8.00022-0. PMID: 26948366
Chemotherapy in glioma.
Taal W, Bromberg JE, van den Bent MJ
CNS Oncol 2015;4(3):179-92. Epub 2015 Apr 23 doi: 10.2217/cns.15.2. PMID: 25906059Free PMC Article
Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402.
Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J, Fink K, Souhami L, Laperriere N, Curran W, Mehta M
J Clin Oncol 2013 Jan 20;31(3):337-43. Epub 2012 Oct 15 doi: 10.1200/JCO.2012.43.2674. PMID: 23071247Free PMC Article
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Prognosis

Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma.
Buckner JC, Shaw EG, Pugh SL, Chakravarti A, Gilbert MR, Barger GR, Coons S, Ricci P, Bullard D, Brown PD, Stelzer K, Brachman D, Suh JH, Schultz CJ, Bahary JP, Fisher BJ, Kim H, Murtha AD, Bell EH, Won M, Mehta MP, Curran WJ Jr
N Engl J Med 2016 Apr 7;374(14):1344-55. doi: 10.1056/NEJMoa1500925. PMID: 27050206Free PMC Article
Low-grade and anaplastic oligodendroglioma.
Van Den Bent MJ, Bromberg JE, Buckner J
Handb Clin Neurol 2016;134:361-80. doi: 10.1016/B978-0-12-802997-8.00022-0. PMID: 26948366
Glioma biology and molecular markers.
Cohen AL, Colman H
Cancer Treat Res 2015;163:15-30. doi: 10.1007/978-3-319-12048-5_2. PMID: 25468223
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Clinical prediction guides

Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article
Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma.
Buckner JC, Shaw EG, Pugh SL, Chakravarti A, Gilbert MR, Barger GR, Coons S, Ricci P, Bullard D, Brown PD, Stelzer K, Brachman D, Suh JH, Schultz CJ, Bahary JP, Fisher BJ, Kim H, Murtha AD, Bell EH, Won M, Mehta MP, Curran WJ Jr
N Engl J Med 2016 Apr 7;374(14):1344-55. doi: 10.1056/NEJMoa1500925. PMID: 27050206Free PMC Article
Low-grade and anaplastic oligodendroglioma.
Van Den Bent MJ, Bromberg JE, Buckner J
Handb Clin Neurol 2016;134:361-80. doi: 10.1016/B978-0-12-802997-8.00022-0. PMID: 26948366
Oligodendroglioma: pathology, molecular mechanisms and markers.
Wesseling P, van den Bent M, Perry A
Acta Neuropathol 2015 Jun;129(6):809-27. Epub 2015 May 6 doi: 10.1007/s00401-015-1424-1. PMID: 25943885Free PMC Article
Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402.
Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J, Fink K, Souhami L, Laperriere N, Curran W, Mehta M
J Clin Oncol 2013 Jan 20;31(3):337-43. Epub 2012 Oct 15 doi: 10.1200/JCO.2012.43.2674. PMID: 23071247Free PMC Article

Recent systematic reviews

Genetically Distinct Oligosarcoma Arising from Oligodendroglioma: Systematic Review & Illustrative Case Example.
Evans AR, Prather KY, Battiste J, Fung KM, Dunn IF, Graffeo CS
World Neurosurg 2024 May;185:e1093-e1100. Epub 2024 Mar 13 doi: 10.1016/j.wneu.2024.03.028. PMID: 38490447
Early versus delayed postoperative radiotherapy for treatment of low-grade gliomas.
Dhawan S, Patil CG, Chen C, Venteicher AS
Cochrane Database Syst Rev 2020 Jan 20;1(1):CD009229. doi: 10.1002/14651858.CD009229.pub3. PMID: 31958162Free PMC Article
Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Nahed BV, Redjal N, Brat DJ, Chi AS, Oh K, Batchelor TT, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):609-30. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1910-2. PMID: 26530264
Early versus delayed postoperative radiotherapy for treatment of low-grade gliomas.
Sarmiento JM, Venteicher AS, Patil CG
Cochrane Database Syst Rev 2015 Jun 29;6(6):CD009229. doi: 10.1002/14651858.CD009229.pub2. PMID: 26118544Free PMC Article
Adjuvant chemotherapy for adults with malignant glioma: a systematic review.
Perry J, Laperriere N, Zuraw L, Chambers A, Spithoff K, Cairncross JG; Neuro-oncology Disease Site Group; Cancer Care Ontario Program in Evidence-Based Care
Can J Neurol Sci 2007 Nov;34(4):402-10. doi: 10.1017/s0317167100007265. PMID: 18062446

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