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Items: 3

1.

Abortive cerebellar ataxia

'Behr syndrome' is a clinical term that refers to the constellation of early-onset optic atrophy accompanied by neurologic features, including ataxia, pyramidal signs, spasticity, and mental retardation (Behr, 1909; Thomas et al., 1984). Patients with mutations in genes other than OPA1 can present with clinical features reminiscent of Behr syndrome. Mutations in one of these genes, OPA3 (606580), result in type III 3-methylglutaconic aciduria (MGCA3; 258501). Lerman-Sagie (1995) noted that the abnormal urinary pattern in MGCA3 may not be picked up by routine organic acid analysis, suggesting that early reports of Behr syndrome with normal metabolic features may actually have been 3-methylglutaconic aciduria type III. [from OMIM]

MedGen UID:
66358
Concept ID:
C0221061
Disease or Syndrome
2.

Isolated microphthalmia 8

Any isolated microphthalmia in which the cause of the disease is a mutation in the ALDH1A3 gene. [from MONDO]

MedGen UID:
767438
Concept ID:
C3554524
Disease or Syndrome
3.

Early-onset progressive encephalopathy-hearing loss-pons hypoplasia-brain atrophy syndrome

A rare genetic neurological disorder with characteristics of early-onset severe global developmental delay with regression, congenital or acquired microcephaly, hearing loss, truncal hypotonia, appendicular spasticity, and dystonia and/or myoclonus. Additional reported manifestations include seizures, optic atrophy, cortical visual impairment, scoliosis, and dysphagia. Brain imaging shows pontine hypoplasia, partial agenesis of the corpus callosum, and diffuse cerebral atrophy with relative sparing of the cerebellum. [from SNOMEDCT_US]

MedGen UID:
1798652
Concept ID:
C5567229
Disease or Syndrome
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