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Oligospermia

MedGen UID:
18162
•Concept ID:
C0028960
•
Disease or Syndrome
Synonyms: Hypospermatogeneses; Hypospermatogenesis; Low Sperm Count; Low Sperm Counts; Oligoasthenoteratozoospermia; Oligoasthenoteratozoospermias; Oligozoospermia; Sperm Count, Low; Sperm Counts, Low
 
Monarch Initiative: MONDO:0001913

Definition

Decreased number of spermatozoa in the semen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOligospermia

Professional guidelines

PubMed

Male factor infertility and assisted reproductive technologies: indications, minimum access criteria and outcomes.
Mazzilli R, Rucci C, Vaiarelli A, Cimadomo D, Ubaldi FM, Foresta C, Ferlin A
J Endocrinol Invest 2023 Jun;46(6):1079-1085. Epub 2023 Jan 12 doi: 10.1007/s40618-022-02000-4. PMID: 36633791Free PMC Article
Recent advances in clinical diagnosis and treatment of male factor infertility.
Miller D, Vukina J
Postgrad Med 2020 Dec;132(sup4):28-34. Epub 2020 Oct 28 doi: 10.1080/00325481.2020.1830589. PMID: 32990123
Fertility management of Klinefelter syndrome.
Fainberg J, Hayden RP, Schlegel PN
Expert Rev Endocrinol Metab 2019 Nov;14(6):369-380. Epub 2019 Oct 7 doi: 10.1080/17446651.2019.1671821. PMID: 31587581

Recent clinical studies

Etiology

Metabolomic analysis of seminal fluids in infertile individuals.
Arslan E, Koyuncu I, Temız E, Arı M, Uyanıkoglu H
Eur Rev Med Pharmacol Sci 2023 Dec;27(24):11923-11931. doi: 10.26355/eurrev_202312_34791. PMID: 38164856
Fertility outcomes in men with prior history of anabolic steroid use.
Ledesma BR, Weber A, Venigalla G, Muthigi A, Thomas J, Narasimman M, White J, Ramasamy R
Fertil Steril 2023 Dec;120(6):1203-1209. Epub 2023 Sep 26 doi: 10.1016/j.fertnstert.2023.09.016. PMID: 37769866Free PMC Article
Modeling methods for busulfan-induced oligospermia and asthenozoospermia in mice: a systematic review and meta-analysis.
Pu R, Liu J, Zhang A, Yang J, Zhang W, Long X, Ren X, Hua H, Shi D, Zhang W, Liu L, Liu Y, Wu Y, Bai Y, Cheng N
J Assist Reprod Genet 2023 Jan;40(1):19-32. Epub 2022 Dec 12 doi: 10.1007/s10815-022-02674-y. PMID: 36508035Free PMC Article
Acupuncture for oligospermia and asthenozoospermia: A systematic review and meta-analysis.
Jia W, Wang C, Yin Y
Medicine (Baltimore) 2021 Dec 3;100(48):e27816. doi: 10.1097/MD.0000000000027816. PMID: 35049183Free PMC Article
Nonobstructive azoospermia.
Chan PT, Schlegel PN
Curr Opin Urol 2000 Nov;10(6):617-24. doi: 10.1097/00042307-200011000-00015. PMID: 11148736

Diagnosis

Nonsurgical Management of Oligozoospermia.
Choy JT, Amory JK
J Clin Endocrinol Metab 2020 Dec 1;105(12):e4194-207. doi: 10.1210/clinem/dgaa390. PMID: 32583849Free PMC Article
European Academy of Andrology guideline Management of oligo-astheno-teratozoospermia.
Colpi GM, Francavilla S, Haidl G, Link K, Behre HM, Goulis DG, Krausz C, Giwercman A
Andrology 2018 Jul;6(4):513-524. doi: 10.1111/andr.12502. PMID: 30134082
Male infertility.
Chow V, Cheung AP
J Reprod Med 2006 Mar;51(3):149-56. PMID: 16674008
Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte.
Palermo G, Joris H, Devroey P, Van Steirteghem AC
Lancet 1992 Jul 4;340(8810):17-8. doi: 10.1016/0140-6736(92)92425-f. PMID: 1351601
The male factor.
Troen P, Oshima H
N Engl J Med 1980 Sep 25;303(13):751-2. doi: 10.1056/NEJM198009253031309. PMID: 7402272

Therapy

Fertility outcomes in men with prior history of anabolic steroid use.
Ledesma BR, Weber A, Venigalla G, Muthigi A, Thomas J, Narasimman M, White J, Ramasamy R
Fertil Steril 2023 Dec;120(6):1203-1209. Epub 2023 Sep 26 doi: 10.1016/j.fertnstert.2023.09.016. PMID: 37769866Free PMC Article
Acupuncture for oligospermia and asthenozoospermia: A systematic review and meta-analysis.
Jia W, Wang C, Yin Y
Medicine (Baltimore) 2021 Dec 3;100(48):e27816. doi: 10.1097/MD.0000000000027816. PMID: 35049183Free PMC Article
Empiric therapy for idiopathic oligoasthenoteratozoospermia.
García-Baquero R, Fernández-Ávila CM, Álvarez-Ossorio JL
Actas Urol Esp (Engl Ed) 2020 Jun;44(5):281-288. Epub 2020 Apr 10 doi: 10.1016/j.acuro.2019.10.007. PMID: 32284159
Male contraception.
Chao J, Page ST, Anderson RA
Best Pract Res Clin Obstet Gynaecol 2014 Aug;28(6):845-57. Epub 2014 Jun 5 doi: 10.1016/j.bpobgyn.2014.05.008. PMID: 24947599Free PMC Article
Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia.
Biswas TK, Pandit S, Mondal S, Biswas SK, Jana U, Ghosh T, Tripathi PC, Debnath PK, Auddy RG, Auddy B
Andrologia 2010 Feb;42(1):48-56. doi: 10.1111/j.1439-0272.2009.00956.x. PMID: 20078516

Prognosis

Fertility outcomes in men with prior history of anabolic steroid use.
Ledesma BR, Weber A, Venigalla G, Muthigi A, Thomas J, Narasimman M, White J, Ramasamy R
Fertil Steril 2023 Dec;120(6):1203-1209. Epub 2023 Sep 26 doi: 10.1016/j.fertnstert.2023.09.016. PMID: 37769866Free PMC Article
Fertility management of Klinefelter syndrome.
Fainberg J, Hayden RP, Schlegel PN
Expert Rev Endocrinol Metab 2019 Nov;14(6):369-380. Epub 2019 Oct 7 doi: 10.1080/17446651.2019.1671821. PMID: 31587581
Spermatogenic failure and the Y chromosome.
Krausz C, Casamonti E
Hum Genet 2017 May;136(5):637-655. Epub 2017 Apr 29 doi: 10.1007/s00439-017-1793-8. PMID: 28456834
Male infertility.
Chow V, Cheung AP
J Reprod Med 2006 Mar;51(3):149-56. PMID: 16674008
Nonobstructive azoospermia.
Chan PT, Schlegel PN
Curr Opin Urol 2000 Nov;10(6):617-24. doi: 10.1097/00042307-200011000-00015. PMID: 11148736

Clinical prediction guides

Metabolomic analysis of seminal fluids in infertile individuals.
Arslan E, Koyuncu I, Temız E, Arı M, Uyanıkoglu H
Eur Rev Med Pharmacol Sci 2023 Dec;27(24):11923-11931. doi: 10.26355/eurrev_202312_34791. PMID: 38164856
Fertility outcomes in men with prior history of anabolic steroid use.
Ledesma BR, Weber A, Venigalla G, Muthigi A, Thomas J, Narasimman M, White J, Ramasamy R
Fertil Steril 2023 Dec;120(6):1203-1209. Epub 2023 Sep 26 doi: 10.1016/j.fertnstert.2023.09.016. PMID: 37769866Free PMC Article
Modeling methods for busulfan-induced oligospermia and asthenozoospermia in mice: a systematic review and meta-analysis.
Pu R, Liu J, Zhang A, Yang J, Zhang W, Long X, Ren X, Hua H, Shi D, Zhang W, Liu L, Liu Y, Wu Y, Bai Y, Cheng N
J Assist Reprod Genet 2023 Jan;40(1):19-32. Epub 2022 Dec 12 doi: 10.1007/s10815-022-02674-y. PMID: 36508035Free PMC Article
Historical investigations into varicocele pathophysiology and sperm migration.
Kathrins M
Fertil Steril 2018 Jan;109(1):75-76. Epub 2017 Dec 20 doi: 10.1016/j.fertnstert.2017.11.007. PMID: 29274657
Male infertility.
Chow V, Cheung AP
J Reprod Med 2006 Mar;51(3):149-56. PMID: 16674008

Recent systematic reviews

Azoospermia factor c microdeletions and outcomes of assisted reproductive technology: a systematic review and meta-analysis.
Colaco S, Modi D
Fertil Steril 2024 Jan;121(1):63-71. Epub 2023 Nov 3 doi: 10.1016/j.fertnstert.2023.10.029. PMID: 37923163
Male infertility and urological tumors: Pathogenesis and therapeutical implications.
Gulino G, Distante A, Akhundov A, Bassi PF
Urologia 2023 Nov;90(4):622-630. Epub 2023 Jul 25 doi: 10.1177/03915603221146147. PMID: 37491831Free PMC Article
Modeling methods for busulfan-induced oligospermia and asthenozoospermia in mice: a systematic review and meta-analysis.
Pu R, Liu J, Zhang A, Yang J, Zhang W, Long X, Ren X, Hua H, Shi D, Zhang W, Liu L, Liu Y, Wu Y, Bai Y, Cheng N
J Assist Reprod Genet 2023 Jan;40(1):19-32. Epub 2022 Dec 12 doi: 10.1007/s10815-022-02674-y. PMID: 36508035Free PMC Article
Acupuncture for oligospermia and asthenozoospermia: A systematic review and meta-analysis.
Jia W, Wang C, Yin Y
Medicine (Baltimore) 2021 Dec 3;100(48):e27816. doi: 10.1097/MD.0000000000027816. PMID: 35049183Free PMC Article
Bromocriptine for idiopathic oligo/asthenospermia.
Vandekerckhove P, Lilford R, Vail A, Hughes E
Cochrane Database Syst Rev 2000;1996(2):CD000152. doi: 10.1002/14651858.CD000152. PMID: 10796498Free PMC Article

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      Clinical tests in GTR
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