NLR Family, Pyrin Domain-Containing 3 Protein

An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.

Year introduced: 2017

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Tree Number(s): D12.644.360.539.250

MeSH Unique ID: D000071199

Entry Terms:

• NLR Family, Pyrin Domain Containing 3 Protein
• NLRP3 Protein
• Cold Autoinflammatory Syndrome 1 Protein
• NACHT, LRR and PYD Domains-Containing Protein 3
• NACHT, LRR and PYD Domains Containing Protein 3

Previous Indexing:

• Carrier Proteins (2002-2016)

See Also:

• Cryopyrin-Associated Periodic Syndromes
• Inflammasomes

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Peptides
Intracellular Signaling Peptides and Proteins
NLR Proteins
NLR Family, Pyrin Domain-Containing 3 Protein