Spastic Paraplegia, Hereditary
A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
Year introduced: 1991(1989)
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Tree Number(s): C10.500.300.820, C10.574.500.495.820, C10.668.829.800.300.820, C16.131.666.300.820, C16.320.400.375.820
MeSH Unique ID: D015419
Entry Terms:
- Hereditary Spastic Paraplegia
- Hereditary Spastic Paraplegias
- Paraplegia, Hereditary Spastic
- Paraplegias, Hereditary Spastic
- Spastic Paraplegias, Hereditary
- Paraplegia, Spastic, Hereditary
- Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia
- Hypertrophic Motor Sensory Neuropathy Spastic Paraplegia
- Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy
- Spastic Paraplegia Hypertrophic Motor Sensory Neuropathy
- X-Linked, Spastic Paraplegia, Hereditary
- Hereditary X-Linked Recessive Spastic Paraplegia
- Hereditary X Linked Recessive Spastic Paraplegia
- Hereditary, Spastic Paraplegia, X-Linked Recessive
- Spastic Paraplegia, Hereditary, X-Linked Recessive
- Spastic Paraplegia, X-Linked Recessive, Hereditary
- X-linked Recessive Hereditary Spastic Paraplegia
- Spastic Paraplegia Type 2
- Spastic Paraplegia 2
- X Linked Recessive Hereditary Spastic Paraplegia
- Hereditary Autosomal Dominant Spastic Paraplegia
- Autosomal Dominant Spastic Paraplegia Hereditary
- Autosomal Dominant Hereditary Spastic Paraplegia
- Spastic Paraplegia, Autosomal Dominant, Hereditary
- Spastic Paraplegia, Hereditary, Autosomal Dominant
- Hereditary, Spastic Paraplegia, Autosomal Dominant
- Charcot-Marie-Tooth Disease with Pyramidal Features, Autosomal Dominant
- Charcot Marie Tooth Disease with Pyramidal Features, Autosomal Dominant
- Peroneal Muscular Atrophy with Pyramidal Features, Autosomal Dominant
- Autosomal Recessive Hereditary Spastic Paraplegia
- Hereditary Autosomal Recessive Spastic Paraplegia
- Spastic Paraplegia, Autosomal Recessive, Hereditary
- Spastic Paraplegia, Hereditary, Autosomal Recessive
- Hereditary Spastic Paraplegia, Autosomal Recessive
- Autosomal Recessive Spastic Paraplegia, Hereditary
- Hereditary Motor-Sensory Neuropathy with Pyramidal Signs
- Hereditary Motor Sensory Neuropathy with Pyramidal Signs
- HMSN V (Hereditary Motor and Sensory Neuropathy Type V)
- Type V Hereditary Motor and Sensory Neuropathy
- Hereditary Motor and Sensory Neuropathy 5
- Hereditary Motor And Sensory Neuropathy V
- HMSN V
- CMT with Pyramidal Features
- HMSN 5
- HMSN Type V
- Type V, HMSN
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