Sirtuins
A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.
Year introduced: 2003
PubMed search builder options
Subheadings:
Tree Number(s): D08.811.277.087.520.200.650, D08.811.913.400.725.115.961, D12.776.476.900
MeSH Unique ID: D037761
Registry Number: EC 3.5.1.-
Entry Terms:
- SIRT
- Sirtuin
- SIRTs
- Silent Mating Type Information Regulator 2-like Proteins
- Silent Mating Type Information Regulator 2 like Proteins
- Sir2-like Proteins
- Sir2 like Proteins
Previous Indexing:
See Also: