Colorectal Neoplasms, Hereditary Nonpolyposis
A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
Year introduced: 1987
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Subheadings:
Tree Number(s): C04.588.274.476.411.307.190, C04.700.250, C06.301.371.411.307.190, C06.405.249.411.307.190, C06.405.469.158.356.190, C06.405.469.491.307.190, C16.320.700.250, C18.452.284.255
MeSH Unique ID: D003123
Entry Terms:
- Hereditary Nonpolyposis Colorectal Neoplasms
- Familial Nonpolyposis Colon Cancer
- Hereditary Nonpolyposis Colorectal Cancer
- Colon Cancer, Familial Nonpolyposis
- Colorectal Cancer Hereditary Nonpolyposis
- Hereditary Nonpolyposis Colon Cancer
- Lynch Syndrome
- Syndrome, Lynch
- Lynch Syndrome I
- Colorectal Cancer, Hereditary Nonpolyposis, Type 1
- Colon Cancer, Familial Nonpolyposis, Type 1
- Hereditary Nonpolyposis Colorectal Cancer Type 1
- Familial Nonpolyposis Colon Cancer Type 1
- Lynch Cancer Family Syndrome I