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Imatinib Mesylate
A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors.
Year introduced: 2016 (1996)
Antineoplastic Agents
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Tyrosine Kinase Inhibitors
Protein kinase inhibitors that inhibit TYROSINE PROTEIN KINASES.
Year introduced: 2023
Pyrimidines
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
Year introduced: THONZYLAMINE was heading 1972-1984 (Prov 1972)
Piperazines
Compounds that are derived from PIPERAZINE.
Organic Chemicals
A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.
Year introduced: 1998
Hydrocarbons, Cyclic
Organic compounds composed exclusively of carbon and hydrogen forming a closed ring that may be either alicyclic or aromatic.
Hydrocarbons, Aromatic
Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.
Hydrocarbons
Organic compounds that primarily contain carbon and hydrogen atoms with the carbon atoms forming a linear or circular structure.
Heterocyclic Compounds, 1-Ring
Organic compounds that contain a ring structure made up of carbon and one or more additional elements such as nitrogen and oxygen.
Heterocyclic Compounds
Cyclic compounds that include atoms other than carbon in their ring structure.
Carboxylic Acids
Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.
Year introduced: 1973(1971)
Benzoates
Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.
Year introduced: 1963
Benzene Derivatives
Organic compounds derived from BENZENE.
Year introduced: 1968
Benzamides
BENZOIC ACID amides.
Year introduced: 1973
Amides
Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant and Hackh's Chemical Dictionary, 5th ed)
Acids, Carbocyclic
Carboxylic acids that have a homocyclic ring structure in which all the ring atoms are carbon.
Protein Kinase Inhibitors
Agents that inhibit PROTEIN KINASES.
Year introduced: 2005
Therapeutic Uses
Uses of chemicals which affect the course of conditions, diseases, syndromes or pathology to benefit the health of an individual.
Year introduced: 2004
Molecular Mechanisms of Pharmacological Action
Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY.
Year introduced: 2008(2004)