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P18-I10 peptide [Supplementary Concept]
Date introduced: April 20, 2004
env Gene Products, Human Immunodeficiency Virus
Proteins encoded by the ENV GENE of the HUMAN IMMUNODEFICIENCY VIRUS.
Year introduced: 2008
Human Immunodeficiency Virus Proteins
Proteins synthesized by HUMAN IMMUNODEFICIENCY VIRUSES such as the HIV-1 and HIV-2.
HIV Envelope Protein gp120
External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.
Year introduced: 1990
Gene Products, env
Retroviral proteins, often glycosylated, coded by the envelope (env) gene. They are usually synthesized as protein precursors (POLYPROTEINS) and later cleaved into the final viral envelope glycoproteins by a viral protease.
Viral Structural Proteins
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
HIV Antigens
Antigens associated with specific proteins of the human adult T-cell immunodeficiency virus (HIV); also called HTLV-III-associated and lymphadenopathy-associated virus (LAV) antigens.
Year introduced: 1989
Viral Proteins
Proteins found in any species of virus.
Viral Envelope Proteins
Integral membrane proteins that are incorporated into the VIRAL ENVELOPE. They are glycosylated during VIRAL ASSEMBLY.
Year introduced: 1984
Retroviridae Proteins
Proteins from the family Retroviridae. The most frequently encountered member of this family is the Rous sarcoma virus protein.
Year introduced: 1986
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Year introduced: /metabolism was PROTEIN METABOLISM 1963-1965
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS.
Peptide Fragments
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Year introduced: 1974
Biological Factors
Endogenously synthesized compounds that influence biological processes not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS.
Antigens, Viral
Substances elaborated by viruses that have antigenic activity.
Year introduced: 1973
Antigens
Substances that are recognized by the immune system and induce an immune reaction.
Amino Acids, Peptides, and Proteins
Amino acids and chains of amino acids connected by peptide linkages.
Year introduced: 1998