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Potentiation of KD-247-induced viral neutralizing activity against SHIV KS2661 infected in human TZM-bl cells assessed as fold reduction in KD-247 IC50 for viral neutralization at 10 uM measured after 48 hrs by luciferase assay relative to KD-247
Assay data:1 Tested
SummaryPubMed Citation
Potentiation of KD-247-induced viral neutralizing activity against SHIV KS2661 infected in human TZM-bl cells assessed as KD-247 IC50 for viral neutralization at 20 uM measured after 48 hrs by luciferase assay (Rvb = 2.422 ug/ml)
Assay data:2 Tested
Potentiation of KD-247-induced viral neutralizing activity against SHIV KS2661 infected in human TZM-bl cells assessed as KD-247 IC50 for viral neutralization at 10 uM measured after 48 hrs by luciferase assay (Rvb = 2.422 ug/ml)
Potentiation of KD-247-induced viral neutralizing activity against SHIV KS2661 infected in human TZM-bl cells assessed as KD-247 IC50 for viral neutralization at 5 uM measured after 48 hrs by luciferase assay (Rvb = 2.422 ug/ml)
Antiviral activity against nevirapine-resistant SIV mac251 infected in human MT4 cells
Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against Simian immunodeficiency virus infected CEM174 cells assessed as inhibition of virus-induced syncytium after 5 days by microscopic analysis
Assay data:17 Active, 4 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Antiviral activity against Simian immunodeficiency virus infected CEM174 cells assessed as inhibition of viral-induced syncytium formation after 5 days by microscopic analysis
Assay data:16 Active, 1 Activity ≤ 1 µM, 23 Tested
Antiviral activity against Simian immunodeficiency virus PBj infected in human PBMC assessed as inhibition of viral replication by RT activity
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against Simian immunodeficiency virus-mac 251 infected in human PBMC assessed as inhibition of viral replication by RT activity
Antiviral activity against simian immunodeficiency virus 69R infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Antiviral activity against simian immunodeficiency virus Mac251 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Antiretroviral activity against Simian immunodeficiency virus MAC 251 infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested
Antiviral activity against SIV mac251 infected in human Raji cells expressing DC-SIGN gene assessed as prevention of syncytium formation between persistently HIV-1 3B-infected Raji cells and uninfected human C8166 cells after 60 mins by ELISA
Antiviral activity against SIV mac251 infected in human Raji cells expressing DC-SIGN gene assessed as inhibition of virus capture by Raji cells after 60 mins by ELISA
Antiviral activity against SIV mac251 infected in human HUT78 cells assessed as prevention of syncytium formation between persistently SIV mac251-infected HUT-78 cells and uninfected CEM cells after 3 to 4 days by ELISA
Assay data:1 Active, 2 Tested
Antiviral activity against SIV mac251 infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity after 7 days by trypan blue staining
Assay data:2 Active, 2 Tested
Antiviral activity against SIV MAC251 infected in human MT4 cells after 5 days by MTT assay
Assay data:1 Active, 2 Activity ≤ 1 µM, 25 Tested
Antiviral activity against SIV-induced syncytium in human CEM174 cells assessed as inhibition of virus-induced cytopathogenicity after 5 days
Assay data:23 Active, 5 Activity ≤ 1 µM, 25 Tested
Antiviral activity against SIV in human CEM cells assessed as inhibition of virus-induced cytopathogenicity
Assay data:26 Active, 3 Activity ≤ 1 µM, 31 Tested
Antiviral activity against SIV in human CEM cells assessed as protection against virus-induced cytopathogenicity
Assay data:29 Active, 32 Tested
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