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Antiviral activity against Zaire ebolavirus infected in African green monkey Vero cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against Zaire ebolavirus infected in African green monkey Vero cells assessed as reduction in virus induced cytopathic effect preincubated with cells for 1 hr followed by viral infection and measured after 48 hrs
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against ZEBOV at 5 uM
Assay data:1 Active, 2 Tested
Antiviral activity against Zaire ebolavirus infected in african green monkey assessed as reduction in viral infection preincubated for 1 hr followed by viral infection 1 hr and measured after 8 days by crystal violet staining based plaque assay
Assay data:2 Active, 2 Tested
Antiviral activity against Zaire ebola virus infected in African green monkey Vero cells
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of envelope glycoprotein in HIV pseudotyped Zaire Ebolavirus infected in human A549 cells assessed as reduction in virus entry measured after 48 hrs by luciferase reporter gene assay
Assay data:44 Active, 7 Activity ≤ 1 µM, 59 Tested
Inhibition of Zaire Ebola virus pseudoparticle GP HR2 domain-mediated virus-host fusion in human A549 cells incubated for 72 hrs by Bright-Glo reagent based assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of Zaire Ebola virus pseudoparticle GP HR2 domain-mediated virus-host fusion in human 293T cells incubated for 72 hrs by Bright-Glo reagent based assay
Antiviral activity against Zaire ebolavirus infected in African green monkey Vero cells assessed as inhibition of viral infection by measuring reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis
Assay data:1 Active, 7 Tested
Antiviral activity against pseudotyped Ebola virus - Mayinga, Zaire infected in human A549 cells assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay
Assay data:31 Active, 22 Activity ≤ 1 µM, 31 Tested
Antiviral activity against Ebola virus 1976 Mayinga infected in African green monkey Vero cells
Antiviral activity against Ebola virus 1976 Mayinga infected in African green monkey Vero cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay
Antiviral activity against Ebola virus 1976 Mayinga infected in human HeLa cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay
Assay data:11 Active, 6 Activity ≤ 1 µM, 12 Tested
Antiviral activity against Zaire EBOV-Mayinga expressing GFP infected in human HeLa cells preincubated for 1 hr followed by viral infection after 24 hrs by DAPI-staining based fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antiviral activity against Zaire ebolavirus infected in African monkey Vero cells
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Antiviral activity against Zaire ebolavirus infected in human HepG2 cells
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of compound-pretreated Ebolavirus GP pseudotyped in HIV virions infected in human 293T cells assessed as inhibition of viral-cell entry after 48 hrs by luciferase gene assay relative to DMSO-treated control
Assay data:4 Active, 5 Tested
Inhibition of compound-pretreated Ebolavirus GP pseudotyped in HIV virions infected in human HeLa cells assessed as inhibition of viral-cell entry after 48 hrs by luciferase gene assay relative to DMSO-treated control
Antiviral activity against Zaire ebolavirus expressing enhanced GFP in Vero 76 cells after 48 hrs by standard Plaque assay
Assay data:3 Active, 3 Tested
Antiviral activity against Zaire ebolavirus expressing GFP in african green monkey Vero E6 cells after 48 hrs by standard plaque assay
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