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In Vitro Enzyme Activity Assay from Article 10.1021/bi030031h: "Thermodynamic characterization of the binding of nucleotides to glycyl-tRNA synthetase."
Assay data:2 Active, 2 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Insecticidal activity against third instar larvae of Bombyx mori (silkworm) measured after 24 hrs
Assay data:6 Tested
SummaryPubMed Citation
Precocious metamorphosis-inducing activity in Bombyx mori Shunrei x Shougetsu fourth-instar larvae assessed as change in body weight compound applied topically measured every 12 hr during fourth-instar period
Assay data:20 Tested
Summary
Induction of precocious metamorphosis-inducing activity against fourth-instar larvae of Bombyx mori Shunrei x shogetsu compound treated topically
Assay data:25 Tested
Juvenile hormone like activity in fourth-instar larvae of Bombyx mori C137 x N137 assessed as induction of precocious metamorphosis applied topically
Assay data:15 Tested
Juvenile hormone like activity in fourth-instar larvae of Bombyx mori C146 x N137 assessed as induction of precocious metamorphosis applied topically
Insecticidal activity against third instar larvae of silkworm assessed per gm diet
Assay data:4 Tested
Agonist activity at ecdysone receptor in Bombyx mori Bm5 cells after 24 hr by luciferase reporter gene assay
Assay data:70 Active, 56 Activity ≤ 1 µM, 88 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:35 Active, 1 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 40 Tested
Antagonist activity at ecdysone receptor in Bombyx mori Bm5 cells assessed as tebufenozide-induced effect treated 24 hr before tebufenozide challenge measured after 24 hr by luciferase reporter gene assay
Assay data:2 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Cytotoxicity against Bombyx mori Bm5 cells assessed as cell viability after 24 hr by MTT assay
Assay data:2 Active, 10 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of Mamestra brassicae trehalase
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of Bombyx mori trehalase
Dose affording 50% of maximum transactivation for ecdysone receptor from Bombyx mori (BmEcR) and a beta-galactosidase reporter gene in HEK293 cell-line
Assay data:17 Active, 4 Activity ≤ 1 µM, 19 Tested
Dose affording 50% of maximum transactivation for ecdysone receptor from Choristoneura fumiferana (CfEcR) and a luciferase reporter gene in CHO cells; Not tested
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of Bombyx mori Ecdysone receptor V454I and Y474E mutant (amino acids 272-606)-mediated mylz2 gene expression expressed in AB zebrafish embryos transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (468-490) assessed as mylz2-promoter driven fats skeletal muscle specific GFP expression at 10 uM exposed during 3 to 48 hrs post fertilization by Gal4 dependent luciferase reportre gene assay relative to untreated control
Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in HEK293 cells transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (468-490) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control
Assay data:2 Tested
Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in HEK293 cells transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (456-490) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control
Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in HEK293 cells transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (413-476) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control
Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in HEK293 cells transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (413-468) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control
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