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Protein binding in marmoset plasma
Assay data:1 Tested
SummaryPubMed Citation
Cmax in common marmoset at 40 mg/kg, po measured on day 1 by LS/MS/MS analysis
Half life in common marmoset at 40 mg/kg, po measured on day 1 by LS/MS/MS analysis
AUC in common marmoset at 40 mg/kg, po measured on day 1 by LS/MS/MS analysis
Half life in common marmoset at 40 mg/kg, po BID measured on day 1 by LS/MS/MS analysis
Cmax in common marmoset at 40 mg/kg, po BID measured on day 1 by LS/MS/MS analysis
AUC in common marmoset at 40 mg/kg, po BID measured on day 1 by LS/MS/MS analysis
Half life in common marmoset at 40 mg/kg, po BID measured on day 7 by LS/MS/MS analysis
Cmax in common marmoset at 40 mg/kg, po BID measured on day 7 by LS/MS/MS analysis
AUC in common marmoset at 40 mg/kg, po BID measured on day 7 by LS/MS/MS analysis
Tmax in common marmoset at 40 mg/kg, po BID measured on day 7 by LS/MS/MS analysis
Bradykinin-induced licking in male marmoset monkey
Total plasma concentration in human CGRPalpha-induced migraine marmoset model at 3 mg/kg, sc measured after 15 to 105 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Total plasma concentration in human CGRPalpha-induced migraine marmoset model at 7 mg/kg, sc measured after 15 to 105 mins
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
AUC (0-96 or 0-168h) of total radioactivity following single intravenous administration of [14C] aliskiren hemifumarate at 1 mg.Kg-1 level in marmoset
Summary
AUC (0-96 or 0-168h) of unlabeled aliskiren hemifumarate following single intravenous administration of aliskiren hemifumarate at 1 mg.Kg-1 level in marmoset
AUC (0-96 or 0-168h) of total radioactivity following single oral administration of [14C] aliskiren hemifumarate at 3 mg.Kg-1 level in marmoset
AUC (0-96 or 0-168h) of unlabeled aliskiren hemifumarate following single oral administration of aliskiren hemifumarate at 3 mg.Kg-1 level in marmoset
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 100 mg.Kg-1 level studied on day 14 in female Callithrix jacchus
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 50 mg.Kg-1 level studied on day 14 in female Callithrix jacchus
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