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LR2 Assays from US Patent US20240043395: "COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING"
Assay data:57 Active, 26 Activity ≤ 1 µM, 70 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Agonist activity at TLR2/TLR6 (unknown origin) assessed as induction of IL-8 production relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in TNF-alpha production at 0.1 ug/ml incubated for 24 hrs
Assay data:7 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in IL-10 production at 0.1 ug/ml incubated for 24 hrs
Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in IL-6 production at 0.1 ug/ml incubated for 24 hrs
Agonist activity at human TLR2/TLR6 expressed in HEK-Blue hTLR2-TLR6 cells by SEAP reporter gene based Quanti-blue assay
Assay data:11 Active, 4 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at TLR6 in HEK-Blue hTLR2 cells at 0.2 uM incubated for 24 hrs in presence of anti-hTLR6-IgA antibodies measured by Quanti-Blue based SEAP assay
Agonist activity at TLR2/6 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR1-IGA for 2 hrs by ELISA
Agonist activity at TLR2/6 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR6-IGG for 2 hrs by ELISA
Assay data:3 Tested
Agonist activity at wild-type human TLR6 expressed in HEK293 cells up to 25 uM measured after 6 hrs by NF-kappaB luciferase reporter gene assay
Inhibition of PAM2CSK4-induced TLR2/6 activation in human HEK-Blue hTLR2 cells
Assay data:1 Active, 1 Tested
Antagonist activity at TLR2/6 in human THP1 cells assessed as reduction in FSL-1-induced IL6 secretion at 50 uM after 24 hrs by ELISA
Antagonist activity at TLR2/6 in human PBMC cells assessed as reduction in FSL-1-induced IL6 secretion at 20 to 80 uM after 24 hrs by ELISA
Antagonist activity at TLR2/6 in human PBMC cells assessed as reduction in FSL-1-induced TNFalpha secretion at 20 to 80 uM after 24 hrs by ELISA
Inhibition of human TLR2/6 expressed in HEK-Blue cells assessed as inhibition of Pam2CSK4-induced NF-kappaB activation at 20 uM measured after 24 hrs by quanti-blue based SEAP reporter gene assay
Inhibition of human TLR2/6 expressed in HEK293 cells assessed as reduction in Pam2CSK4-induced NFkappaB production at 1.5 to 5 uM incubated for 16 hrs by quanti-blue SEAP assay
Agonist activity at human TLR2/6 expressed in HEK-Blue cells assessed as activation of SEAP at 0.5 uM incubated for 24 hrs by quanti-blue SEAP assay in presence of Anti-hTLR6-IgG
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Antagonist activity at FLAG-tagged human TLR2/TLR6 expressed in HEK293 cells co-expressing pGL3-Elam.luc assessed as inhibition of Pam2CSK4-stimulated NF-kappaB activation preincubated for 1 hr followed by Pam2CSK4 stimulation for 5 hrs by luciferase reporter gene assay
Assay data:2 Tested
Antagonist activity at human TLR2/6 expressed in HEK-blue cells assessed as inhibition of Pam2CSK4-induced IL-8 mRNA expression at 100 uM preincubated for 1 hr followed by Pam2CSK4 induction measured after 1 hr by qRT-PCR method relative to control
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