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Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2A1-mediated 17-epiestriol-3-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Microsomal stability in human liver microsomes assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM and measured for 30 mins in presence of UDPGA by UPLC-MS/MS analysis (Rvb = 100%)
Assay data:7 Tested
Microsomal stability in human liver microsomes assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM and measured for 15 mins in presence of UDPGA by UPLC-MS/MS analysis (Rvb = 100%)
Drug metabolism in human hepatocytes assessed as UGT-mediated glucuronidation by measuring O-glucuronide formation at 10 uM measured after 4 hrs by LC-MS analysis
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2A1-mediated 17-epiestriol-16-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2A1-mediated 17-epiestriol-17-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2A1-mediated 16-epiestriol-17-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2A1-mediated 16-epiestriol-16-glucuronide formation after 15 to 60 mins by Michaelis-Menten equation analysis in presence of UDPGA
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2A1-mediated estriol-16-glucuronide formation after 15 to 60 mins by Michaelis-Menten equation analysis in presence of UDPGA
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2A1-mediated 17-epiestriol-17-glucuronide formation at 5 mg after 5 hrs by NMR spectroscopic analysis in presence of UDPGA
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2A2-mediated 17-epiestriol-17-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2A2-mediated 13-epiestradiol-3-glucuronide/13-epiestradiol-17-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2A1-mediated 13-epiestradiol-3-glucuronide/13-epiestradiol-17-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA
Microsomal stability in human liver microsomes assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM and measured for 60 mins in presence of UDPGA by UPLC-MS/MS analysis (Rvb = 100%)
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2A2-mediated estradiol-3-glucuronide/estradiol-17-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2A1-mediated estradiol-3-glucuronide/estradiol-17-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA
Drug level assessed as recombinant human C-terminal His-tagged UGT2A2-mediated compound formation from at 200 uM 13-epiestradiol after 15 to 60 mins by HPLC analysis in presence of UDPGA
Assay data:2 Tested
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
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