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Inhibition of tubulin polymerization (unknown origin) incubated for 15 mins followed by GTP addition and measured for 20 mins by spectrophotometry
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Disruption of microtubule network in human A549 cells assessed as membrane organization disruption at 5 uM incubated for 24 hrs by DAPI staining based confocal microscopic analysis
Assay data:2 Active, 2 Tested
Inhibition of tubulin polymerization in human A549 cells assessed as appearance of short microtubule at 0.357 uM measured after 24 hrs by immunofluorescence confocal microscopic analysis
Induction of microtubule disruption in human MHCC97H cells assessed as occurence of cell shrinkage at 10 nM measured after 8 hrs by immunofluorescence based confocal microscopic analysis
Disruption of microtubule network in human HGC-27 cells assessed as irregular form of filamentous microtubule structures at 10 to 30 nM measured after 48 hrs by DAPI staining based fluorescence microscopic analysis
Inhibition of tubulin polymerization (unknown origin) measured every 3 secs for 1 hr by spectroflourimetric analysis
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of tubulin polymerization in human KYSE-450 cells assessed as inhibition of cell growth after 48 hrs relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of tubulin (unknown origin) polymerization at 10 uM measured every 1 min over 20 mins by fluorescence assay relative to control
Assay data:6 Tested
Inhibition of tubulin polymerization in human MOLM-13 cells assessed as disruption of microtubule network at 200 nM after 18 hrs by FITC-staining based flow cytometry analysis
Induction of microtubule depolymerization in human A10 cells at 2 times EC50 incubated for 18 hrs by indirect immunofluorescence analysis
Assay data:6 Active, 6 Tested
Disruption of microtubule network in human HCT116 cells assessed as microtubule disorganization at 50 nM for 18 hrs by FITC/DAPI staining-based confocal microscopic analysis
Inhibition of colchicine binding to tubulin (unknown origin) by ITC method
Inhibition of tubulin polymerization in human HeLa cells assessed as appearance of rounded microtubule at 3 uM after 24 hrs by DAPI staining based confocal microscopic analysis
Inhibition of tubulin polymerization (unknown origin) in glycerol-assembly buffer assessed as time required to reach 50% of polymerization equilibrium at 27.5 uM measured every 30 secs for 2 hrs in presence of GTP (Rvb = 16.5 +/- 0.8 min)
Assay data:5 Tested
Induction of microtubule instability in human MCF7 cells assessed as time spent for shortening at IC25 for mitotic block measured after 20 hrs by immunofluorescence analysis (Rvb = 0.2 +/- 0.07 min)
Assay data:3 Tested
SummaryRelated BioAssays by Target
Binding affinity to tubulin in human HepG2 cells at 5 uM after 4 hrs by EBI competition assay
Assay data:1 Active, 5 Tested
Inhibition of tubulin polymerization in human HeLa cells assessed as microtubules spent time in attenuated state at 50 uM
Displacement of (E)-3-(4-(Dimethylamino)phenyl)-1-(4'-fluoro[1,1'-biphenyl]-2-yl)prop-2-en-1-one from tubulin (unknown origin) by fluorescence assay
Assay data:2 Tested
Inhibition of MAP-rich tubulin (unknown origin) polymerization at 10 uM measured every 30 seconds for 30 mins by spectrophotometry
Inhibition of tubulin (unknown origin) polymerization
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