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Inhibition of pET3a-His-tagged DJ1 (unknown origin) expressed in Escherichia coli BL21 assessed as decrease in esterase activity using DiFMUAc as substrate
Assay data:18 Active, 13 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of PARK7 in human HEK293T cells assessed as reduction in JQ-92 labelled PARK7 band intensity at 0.1 to 50 uM incubated for 1 hr followed by incubation with JQ-92 for 30 mins by fluorescence scanning based analysis
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of PARK7 in human HEK293T cells assessed as reduction in JQ-92 labelled PARK7 band intensity at 1 uM incubated for 1 hr followed by incubation with JQ-92 for 30 mins by fluorescence scanning based analysis
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells using DiFMUAc as substrate at 12.5 to 100 uM preincubated with enzyme for 1 hr followed by substrate addition and measured for 1 hr by DiFMUAc assay based fluorescence analysis
Inhibition of N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells assessed as reduction in JQ-107-labelled PARK7 band intensity incubated for 1 hr followed by incubation with JQ-107 and measured for 2 hrs by fluorescence polarization assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells assessed as ratio of Kinact/Ki by fluorescence polarization assay
Inhibition of PARK7 in human HEK293T cells assessed as reduction in JQ-92 labelled PARK7 band intensity incubated for 1 hr followed by incubation with JQ-92 for 30 mins by fluorescence scanning based analysis
Binding affinity to PARK7 in UCHL1 knockdown human HEK293T cells at 1 uM incubated for 1 hr by fluorescence scanning based analysis
Assay data:1 Active, 1 Tested
Inhibition of N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells using SRK59 as fluorescent probe at 2 uM preincubated for 1 hr followed by SRK59 addition for 30 mins by Gel-based competition assay
Assay data:3 Active, 7 Tested
Binding affinity to PARK7 in human HEK293T cells at 0.5 to 1 uM incubated for 1 hr by western blot analysis
Binding affinity to N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells at 2 uM measured after 1 hr by fluorescence scanning analysis
Binding affinity to N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells at 2 uM measured after 1 hr by coomassie staining based analysis
Binding affinity to PARK7 in human HEK293T cells at 0.5 uM incubated for 1 hr by fluorescence scanning based analysis
Inhibition of N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells using SRK59 as fluorescent probe at 1 to 2 uM preincubated for 1 hr followed by SRK59 addition for 30 mins by Gel-based competition assay
Inhibition of N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells using SRK59 as fluorescent probe at 0.5 uM preincubated for 1 hr followed by SRK59 addition for 30 mins by Gel-based competition assay
Inhibition of N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells using DiFMUAc as substrate preincubated with enzyme for 1 hr followed by substrate addition and measured for 1 hr by DiFMUAc assay based fluorescence analysis
Binding affinity to N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells at 1 uM measured after 1 hr by fluorescence scanning analysis
Assay data:2 Active, 2 Tested
Binding affinity to N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells at 5 uM measured after 1 hr by fluorescence scanning analysis
Binding affinity to N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells at 1 uM measured after 1 hr by coomassie staining based analysis
Binding affinity to N-terminal GST-tagged human recombinant PARK7 expressed in Escherichia coli BL21(DE3)Rosetta2 cells at 5 uM measured after 1 hr by coomassie staining based analysis
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