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In vivo protac activity at VHL/AR in human VCaP cells xenografted SCID mouse assessed as reduction in AR protein level in tumor at 50 mg/kg, ip administered as single dose measured after 3 to 48 hrs Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Invivo inhibition of AR in CWRSA6 prostate cancer cell xenografted in mouse at 50 mg/kg for 4 hrs relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at Androgen receptor (unknown origin) transfected in mouse C2C12 cells measured by luciferase reporter assay
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at Androgen receptor expressed in mouse C2C12 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Androgen Receptor Assay from US Patent US9682960: "Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety"
Assay data:117 Active, 127 Activity ≤ 1 µM, 127 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Agonist activity at AR in mouse SC3 cells assessed as effect on cell proliferation after 3 days by CCK8 assay
Assay data:37 Tested
Antagonist activity at AR in mouse SC3 cells assessed as inhibition of DHT-induced cell proliferation up to 10 uM after 3 days by CCK8 assay
Assay data:12 Tested
Antagonist activity at AR in mouse SC3 cells assessed as inhibition of DHT-induced cell proliferation after 3 days by CCK8 assay
Assay data:17 Active, 7 Activity ≤ 1 µM, 26 Tested
Antagonist activity at AR in mouse SC3 cells assessed as inhibition of DHT-induced cell proliferation at 10 uM after 3 days by CCK8 assay relative to control
Assay data:17 Tested
Antagonist activity at AR in mouse SC3 cells assessed as inhibition of dihydrotestosterone-induced cell growth at 10'-5 M measured after 3 days by CCK8 assay
Antagonist activity at AR in mouse SC3 cells assessed as inhibition of dihydrotestosterone-induced cell growth 10'-5 to 10'-7 M measured after 3 days by CCK8 assay
Assay data:2 Active, 2 Tested
Antagonist activity at mouse androgen receptor expressed in mouse C2C12 cells at 5 uM pretreated for 1 day measured 36 hrs post transfection by luciferase reporter gene assay in presence of DHT
Assay data:6 Active, 6 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Antagonist activity at androgen receptor in mouse SC3 cells assessed as inhibition of DHT-induced cell growth after 3 days by CCK-8/WST-8 assay
Assay data:12 Active, 2 Activity ≤ 1 µM, 19 Tested
Antagonist activity at androgen receptor in mouse SC3 cells assessed as inhibition of DHT-induced cell growth at 10 uM after 3 days by CCK-8/WST-8 assay relative to control
Assay data:3 Tested
Agonist activity at mouse androgen receptor at 10 uM after 24 hrs by cell-based luciferase reporter gene assay relative to control
Assay data:51 Tested
Antagonist activity against mouse androgen receptor assessed as reduction of 10 nM DHT-induced transcriptional activity at 10 uM after 24 hrs by cell-based luciferase reporter gene assay relative to control
Agonist activity at mouse androgen receptor assessed as inhibition of transactivation after 24 hrs by cell-based luciferase reporter gene assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
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