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Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
SummaryPubMed Citation
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Inhibition of CCR7 (unknown origin) at 10 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at CCR7 in human CCRF-CEM cells assessed as inhibition of MIP-3beta-induced calcium flux at 5 uM preincubated for 15 mins by spectrophotometric analysis relative to control
Assay data:5 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Summary
Binding affinity to CCR7 (unknown origin) at 10 uM by radioligand displacement assay
Antagonist activity at CCR7 (unknown origin) assessed as inhibition of calcium flux at 10 uM
Antagonist activity at CCR7 (unknown origin) assessed as inhibition of chemotaxis at 10 uM
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
Agonist activity at CCR7 up to 30 uM
Inhibition of CCR7
Inhibition of CCR7 upto 1 uM
Binding affinity to CCR7 receptor
Inhibition of CCR7 expressed in CHO cells at 10 uM
Displacement of [125I]MIP-3beta from CCR7 expressed in CHO cells
siRNA Circadian Assay
Assay data:527 Active, 33364 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
Antagonist activity at human CCR7 expressed in CHOK1 cells assessed as inhibition of CCL19-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins
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