BioAssay by Target (List) for Gene (Select 14450) - PubChem BioAssay - NCBI

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Select item 13460391.

Mouse phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (Nucleoside synthesis and metabolism)

Source:: IUPHAR/BPS Guide to PHARMACOLOGY

Protein Target:: trifunctional purine biosynthetic protein adenosine-3

Assay data:1 Active, 1 Tested

AID:: 1346039

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 12248282.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout

Source:: Iain Fraser

Assay data:762 Active, 16821 Tested

AID:: 1224828

Summary Related BioAssays by Same Project

Select item 12248263.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:1106 Active, 16821 Tested

AID:: 1224826

Summary Related BioAssays by Same Project

Select item 10532084.

A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:788 Active, 16789 Tested

AID:: 1053208

Summary PubMed Citation

Select item 4598685.

Inhibition of mouse recombinant GARFtase assessed as FGAR formation by spectrophotometry

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:3 Active, 2 Activity ≤ 1 µM, 6 Tested

AID:: 459868

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3624376.

Inhibition of mouse recombinant GARFTase

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:5 Active, 2 Activity ≤ 1 µM, 7 Tested

AID:: 362437

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3498147.

Inhibition of mouse recombinant GARFTase

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:3 Active, 1 Activity ≤ 1 µM, 7 Tested

AID:: 349814

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 758508.

Tested in vitro for its inhibition of trifunctional glycinamide ribonucleotide formyltransferase (GARFT) isolated from murine L1210 leukemia cells

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 75850

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 758499.

Tested for the inhibition of trifunctional Glycinamide ribonucleotide formyltransferase isolated from murine L1210 cells.

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 75849

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 7584810.

Tested for the inhibition against the human dihydrofolate reductase

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 75848

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 7584711.

Inhibitory activity against glycinamide ribonucleotide formyltransferase (GARFT) from L1210 murine leukemic cells

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 75847

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 7584612.

In vitro inhibition of glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cells

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:1 Active, 1 Tested

AID:: 75846

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 7584513.

In vitro inhibition of Glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cells

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 75845

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7287714.

Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzyme

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 72877

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7287515.

Inhibition of GAR transformylase from mammalian Manca

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 72875

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7287416.

potent inhibitor of GAR Tfase obtained from porcine

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:1 Active, 1 Tested

AID:: 72874

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 7287217.

Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:7 Active, 11 Tested

AID:: 72872

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 7287118.

Inhibition of GAR transformylase isolated from the murine lymphoma cell line L5178Y

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:1 Tested

AID:: 72871

Summary PubMed Citation Related BioAssays by Target

Select item 7287019.

In vitro inhibition of mouse GAR transformylase

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 72870

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7286920.

Compound was tested for inhibition constant against GAR TFase in mice

Source:: ChEMBL

Protein Target:: Trifunctional purine biosynthetic protein adenosine-3

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 72869

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (19)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (3)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (16)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (25)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (27)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (3)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (27)
BioAssays extracted from the literature
Other (3)
BioAssays deposited by other experimentalists

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