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Radioligand Binding Assay from US Patent US9079895: "Morpholino compounds, uses and methods"
Assay data:32 Active, 1 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay relative to serotonin
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Late stage for the probe development effort to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A): Luminescence-based cell-based high throughput dose response assay for agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A).
Assay data:2 Active, 1 Activity ≤ 1 µM, 56 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Luminescence-based cell-based high throughput dose response assay for agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A)
Assay data:170 Active, 96 Activity ≤ 1 µM, 238 Tested
Luminescence-based cell-based high throughput confirmation assay for agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A)
Assay data:427 Active, 2266 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Summary of the probe development efforts to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A)
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A)
Assay data:2415 Active, 364131 Tested
The ability to antagonize head twitches in mice, observed after administration of(+/-)- DOI, was used to evaluate 5-HT2A receptor antagonistic property; Not determined
Assay data:3 Tested
The ability to antagonize head twitches in mice, observed after administration of (+/-)- DOI, was used to evaluate 5-HT2A receptor antagonistic property; Not determined
Assay data:1 Tested
The ability to antagonize head twitches in mice, observed after administration of (+/-)- DOI, was used to evaluate 5-HT2A receptor antagonistic property; Antagonist
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Ability to antagonize head twitches in mice, observed after administration of (+/-)- DOI, was used to evaluate 5-HT2A receptor antagonistic property; Not determined
The maximum responses of [3H]- inositol monophosphate accumulation in cells expressing the 5-hydroxytryptamine 2A receptor
Percent of maximum stimulation of phosphatidylinositol turnover at cloned 5-hydroxytryptamine 2A receptor in 3T3 cells
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.
Assay data:35 Active, 3 Activity ≤ 1 nM, 33 Activity ≤ 1 µM, 36 Tested
Hill number was determined for inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in mouse cerebral cortex
Assay data:5 Tested
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