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Inhibition of N-terminal flag tagged mouse JAK1 expressed in baculovirus infected Sf9 cells using biotin-EQEDEPEGDYFEWLE-NH2 as substrate in the presence of [gamma p33]-ATP by FRET assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Effect on JAK1 phosphorylation in mouse MHS cells assessed as phosphorylated JAK1 level at 15 ug/ml by Western blot analysis relative to tubulin (Rvb = 1 No_unit)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of zymosan-induced JAK1 phosphorylation in mouse MHS cells assessed as phosphorylated JAK1 level at 15 ug/ml by Western blot analysis relative to tubulin (Rvb = 2.2 No_unit)
Inhibition of zymosan-induced JAK1 phosphorylation in mouse MHS cells assessed as phosphorylated JAK1 level at 1.5 ug/ml by Western blot analysis relative to tubulin (Rvb = 2.2 No_unit)
Inhibition of zymosan-induced JAK1 phosphorylation in mouse MHS cells preincubated for 30 mins followed by zymosan challenge and measured after 6 to 24 hrs by Western blot analysis
Inhibition of JAK1/Tyk2-mediated STAT4 phosphorylation in IFNalpha-stimulated mouse whole blood
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of JAK1/JAK3 in C57BL/6 mouse CD4-positive T cell assessed as reduction in IL-4-induced STAT6 phosphorylation at 1 to 10 uM pretreated for 1 hr followed by IL-4 addition after 15 mins by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of JAK1/JAK2 in C57BL/6 mouse CD4-positive T cell assessed as reduction in IFNgamma-induced STAT3 phosphorylation at 1 to 10 uM pretreated for 1 hr followed by IFNgamma addition after 15 mins by Western blot analysis
Inhibition of JAK1/JAK2 in C57BL/6 mouse CD4-positive T cell assessed as reduction in IFNgamma-induced STAT1 phosphorylation at 1 to 10 uM pretreated for 1 hr followed by IFNgamma addition after 15 mins by Western blot analysis
Inhibition of JAK1 in LPS-stimulated mouse RAW264.7 cells assessed as reduction in STAT1 phosphorylation at Y701 residue pretreated for 1 hr followed by LPS-stimulation by Western blot analysis
Inhibition of JAK1 in LPS-stimulated mouse RAW264.7 cells assessed as reduction in STAT1 phosphorylation at S727 residue pretreated for 1 hr followed by LPS-stimulation by Western blot analysis
Inhibition of JAK1 in LPS-stimulated mouse RAW264.7 cells assessed as reduction in STAT3 phosphorylation at Y707 residue pretreated for 1 hr followed by LPS-stimulation by Western blot analysis
Inhibition of JAK3/JAK1 in mouse CTLL-2 cells assessed as reduction in IL2-stimulated STAT5 phosphorylation
Inhibition of FLAG-tagged mouse JAK1 expressed in insect Sf9 cells using biotin-EQEDEPEGDYFEWLE-NH2 as substrate by HTRF assay
Inhibition of JAK1 in mouse BMDM assessed as inhibition of IFNbeta-induced STAT1 phosphorylation at 5 uM preincubated for 3 hrs followed by IFNbeta induction measured after 30 mins by immunoblotting
Assay data:3 Active, 3 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Inhibition of JAK-1 in mouse CTLL cells assessed as inhibition of IL-2-induced stat5 phosphorylation
Inhibition of Jak1 in mouse BA/F3 cells expressing TEL-Jak1 assessed as inhibition of STAT5 phosphorylation by Western blotting analysis
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
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