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Time Resolved Fluorescence Resonance Energy Transfer Assay from Article 10.1016/j.bmcl.2007.04.029: "N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics."
Assay data:42 Active, 25 Activity ≤ 1 µM, 43 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Time Resolved Fluorescence Resonance Energy Transfer Assay from Article 10.1016/j.bmcl.2007.10.076: "Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode."
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Lck Kinase Inhibition Assay from Article 10.1021/jm060727j: "2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase i"
Assay data:54 Active, 13 Activity ≤ 1 nM, 43 Activity ≤ 1 µM, 61 Tested
Inhibition of LCK phosphorylation in Con-A induced BALB/c mouse T cell by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of mouse LCK (2 to 509 residues) assessed as residual activity at 500 nM in presence of 33P-ATP by filter binding assay relative to control
Inhibition of mouse Lck assessed as enzyme residual activity at 100 nM by radiometric filter binding assay relative to control
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of mouse LCK
Percentage Lck activity remaining in the presence of 1uM inhibitor
Assay data:10 Active, 33 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Lck in the presence of 50uM ATP
Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested
Percentage Lck activity remaining in the presence of 3uM inhibitor
Assay data:1 Active, 1 Tested
Percentage Lck activity remaining in the presence of 25uM inhibitor
Assay data:1 Active, 2 Tested
Percentage Lck activity remaining in the presence of 2uM inhibitor
Percentage Lck activity remaining in the presence of 10uM inhibitor
Assay data:5 Active, 24 Tested
Percentage Lck activity remaining in the presence of 0.1uM inhibitor
Assay data:7 Tested
Percentage Lck activity remaining in the presence of 0.01uM inhibitor
Assay data:1 Active, 3 Tested
Reduction of Lck Tyr394 phosphorylation in resting C57BL/6 mouse T cells at 20 uM by Western blot
Reversal of reduction of Lck Tyr394 phosphorylation in resting C57BL/6 mouse T cells at 20 uM by Western blot
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