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Displacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Positive allosteric modulation of NTR1 in ICR mouse brain assessed as increase in [125I]-neurotensin binding measured after 20 mins
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Mouse NTS1 receptor (Neurotensin receptors)
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Agonist activity at NTR1 in mouse N1E-115 cells assessed as increase in intracellular calcium concentration
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to NTR1 in mouse brain membrane
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Tested for change in binding affinity to Neurotensin (NT) receptor in neonatal mouse whole brain (minus cerebellum)
Assay data:7 Tested
SummaryRelated BioAssays by Target
Tested for change in binding affinity in neonatal mouse whole brain (minus cerebellum)
Assay data:1 Tested
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
Assay data:16 Active, 10 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cerebellum)
Inhibitory concentration required for the displacement of [3H]NT from neurotensin receptor in mouse; value ranges from 4-6 uM
SummaryCompounds, ActiveRelated BioAssays by Target
Compound was tested in vitro for its binding affinity against Neurotensin Receptor after peripheral administration
Binding affinity for Neurotensin Receptor
Assay data:13 Active, 5 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
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