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PubChem BioAssay

Biological Activity

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Links from Gene

Items: 13

Select item 19251621.

Inhibition of Gal4-fused Nurr1 in mouse MN9D cells

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 4 group A member 2

Assay data:1 Active, 1 Tested

AID:: 1925162

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18852042.

Agonist activity at Nurr1 in mouse MN9D cells measured by Gal4-based luciferase reporter gene assay

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 4 group A member 2

Assay data:2 Active, 2 Tested

AID:: 1885204

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18852033.

Agonist activity at Nurr1 in mouse MN9D cells measured by NBRE-based luciferase reporter gene assay

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 4 group A member 2

Assay data:2 Active, 2 Tested

AID:: 1885203

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 15728564.

Agonist activity at Nurr1 in mouse MG7 cells assessed as inhibition of LPS-induced neurotoxicity by measuring neuroprotection at 10 uM

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 4 group A member 2

Assay data:2 Tested

AID:: 1572856

Summary PubMed Citation Related BioAssays by Target

Select item 15728555.

Agonist activity at Nurr1 in mouse MG7 cells assessed as inhibition of LPS-induced neurotoxicity by measuring neuroprotection at 3 uM

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 4 group A member 2

Assay data:3 Tested

AID:: 1572855

Summary PubMed Citation Related BioAssays by Target

Select item 15728546.

Agonist activity at Nurr1 in mouse MG7 cells assessed as inhibition of LPS-induced IL1beta secretion at 3 uM

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 4 group A member 2

Assay data:3 Tested

AID:: 1572854

Summary PubMed Citation Related BioAssays by Target

Select item 15728517.

Agonist activity at Nurr1 in mouse N2A cells harboring NBRE by luciferase reporter gene assay

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 4 group A member 2

Assay data:17 Active, 8 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested

AID:: 1572851

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13156668.

Activation of mouse Nurr1 transfected in human SK-N-BE(2)C cells at 0.3 uM in presence of Nurr1 siRNA by luciferase reporter gene assay

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 4 group A member 2

Assay data:2 Tested

AID:: 1315666

Summary PubMed Citation Related BioAssays by Target

Select item 13156649.

Activation of mouse Nurr1 transfected in human SK-N-BE(2)C cells at 0.3 uM by luciferase reporter gene assay relative to control

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 4 group A member 2

Assay data:2 Tested

AID:: 1315664

Summary PubMed Citation Related BioAssays by Target

Select item 131566310.

Activation of mouse Nurr1 transfected in human SK-N-BE(2)C cells by luciferase reporter gene assay

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 4 group A member 2

Assay data:2 Tested

AID:: 1315663

Summary PubMed Citation Related BioAssays by Target

Select item 122482811.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout

Source:: Iain Fraser

Assay data:762 Active, 16821 Tested

AID:: 1224828

Summary Related BioAssays by Same Project

Select item 122482612.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:1106 Active, 16821 Tested

AID:: 1224826

Summary Related BioAssays by Same Project

Select item 105320813.

A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:788 Active, 16789 Tested

AID:: 1053208

Summary PubMed Citation

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BioActivity

Active Compounds (4)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (1)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (4)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (10)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (3)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (10)
BioAssays extracted from the literature
Other (3)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 18227) (13)
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