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Inhibition of mouse uPA using Z-Gly-Gly-Arg-AMC as substrate measured for 15 mins by fluorometric assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enzymatic Assay from Article 10.1074/jbc.M109.067967: "Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1."
Assay data:12 Active, 9 Activity ≤ 1 µM, 13 Tested
Inhibition of the intrinsic peri-cellular uPA in mouse CT26 cells assessed as reduction in cell migration at 100 uM measured every hour by wound healing assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Potency index, ratio of Ki for LD1 to Ki for test compound for inhibition of mouse uPA preincubated for 15 mins followed by chromogenic substrate addition
Inhibition of mouse uPA
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of uPA in presence of 75% mouse serum measured at 24 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of uPA in presence of 75% mouse serum measured at 8 hrs
Inhibition of uPA in presence of 75% mouse serum measured at 2 hrs
Inhibition of uPA in presence of 75% mouse serum measured immediately
Inhibition of the intrinsic peri-cellular uPA in mouse CT26 cells assessed as reduction in cell migration at 30 to 100 uM measured every hour by wound healing assay relative to control
Assay data:4 Tested
Inhibition of the intrinsic peri-cellular uPA in mouse CT26 cells assessed as reduction in cell migration at 33 to 100 uM measured every hour by wound healing assay relative to control
Assay data:2 Tested
Inhibition of the intrinsic peri-cellular uPA in mouse CT26 cells assessed as reduction in cell invasion at 100 uM measured every hour by transwell assay
Inhibition of the intrinsic peri-cellular uPA in mouse CT26 cells assessed as reduction in cell invasion measured every hour by transwell assay
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to mouse uPA expressed in HEK2936E cells by ITC assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to mouse uPA by SPR assay
Binding affinity to mouse uPA assessed as dissociation rate constant after 600 secs by SPR assay
Assay data:3 Tested
Binding affinity to mouse uPA assessed as association rate constant after 90 secs by SPR assay
Inhibition of mouse uPA serine protease domain preincubated for 15 mins followed by chromogenic substrate addition
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of mouse uPA preincubated for 15 mins followed by chromogenic substrate addition
Assay data:1 Active, 2 Tested
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