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Fluorescence Polarization Assay from US Patent US11286268: "EIF4E-inhibiting compounds and methods"
Assay data:1729 Active, 2 Activity ≤ 1 nM, 1677 Activity ≤ 1 µM, 1775 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Potentiation of eIF4E-4EBP1 interaction in human HeLa cells at 6.25 to 100 uM measured after 1 hr by m7-GDP functionalized agarose beads pull down assay based western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of 4E-BP1 phosphorylation in human HCT116 cells at 2 uM after 6 hrs by Western blot analysis
Assay data:7 Active, 8 Tested
Inhibition of eIF4E/4E-BP1 interaction in human T47D cells incubated for 6 hr by m7GDP cap pull down assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of eIF4E/4E-BP1 interaction in human MCF7 cells incubated for 6 hr by m7GDP cap pull down assay
Inhibition of eIF4E/4E-BP1 interaction in human MDA-MB-231 cells incubated for 6 hr by m7GDP cap pull down assay
Inhibition of 4E-BP1 phosphorylation in human HCT116 cells at 1 uM after 6 hrs by Western blot analysis
Inhibition of eIF4E/4E-BP1 interaction in human MDA-MB-231 cells at 5 uM incubated for 6 hr by m7GDP pull down assay
Inhibition of eIF4E/4E-BP1 interaction in human MDA-MB-231 cells incubated for 6 hr by m7GDP pull down assay
Assay data:2 Tested
Inhibition of Halo-tagged biotinylated human eIF4E expressed in Escherichia coli/Halo-tagged methyltetrazine-labelled human 4E-BP1 expressed in Escherichia coli protein-protein interaction incubated for 1 hr by catalytic enzyme-linked click chemistry assay
Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Effect on 4E-BP1 phosphorylation at Thr37/46 in human TMD8 cells at 0.01 to 10 uM after 2 hrs by immunoblot method
Inhibition of 4EBP1 phosphorylation at Ser 65 residues in human Mino cells at 100 uM after 48 hrs in presence of ibrutinib by Western blot analysis
Inhibition of 4EBP1 phosphorylation at Thr 37/46 residues in human Mino cells at 10 to 25 uM after 48 hrs by Western blot analysis
Inhibition of 4EBP1 phosphorylation at Ser 65 residues in human Mino cells at 10 to 25 uM after 48 hrs by Western blot analysis
Inhibition of 4EBP1 phosphorylation at Thr 37/46 residues in human Mino cells at 100 uM after 48 hrs by Western blot analysis
Inhibition of 4EBP1 phosphorylation at Ser 65 residues in human Mino cells at 100 uM after 48 hrs by Western blot analysis
Inhibition of eIF4E-4E-BP1 (unknown origin) interaction at 100 uM by cat-ELCCA
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Induction of 4E-BP1 phosphorylation at Thr70 in human A549 cells at 500 uM after 6 hrs by Western blotting analysis
Assay data:2 Active, 3 Tested
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