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Antagonist activity at RXR-alpha in mouse RAW264.7 cells assessed as supression of bexarotene-induced inhibition of LPS-induced suppressed NO production at 1 uM incubated for 48 hrs by Griess assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at RXR-alpha in mouse RAW264.7 cells assessed as supression of bexarotene-induced inhibition of LPS-induced suppressed Nos2 gene expression at 10 uM incubated for 6 hrs by RT-PCR analysis
Agonist activity at RXR-alpha in mouse RAW264.7 cells assessed as inhibition of LPS-induced suppressed NO production at 0.1 uM incubated for 48 hrs by Griess assay
Agonist activity at RXR-alpha in mouse RAW264.7 cells assessed as inhibition of LPS-induced suppressed Nos2 gene expression at 0.1 uM incubated for 6 hrs by RT-PCR analysis
Agonist activity at RXR-alpha in mouse RAW264.7 cells assessed as inhibition of LPS-induced NF-kappaB transcription by measuring NF-kappaB level at 0.01 to 10 uM incubated for 24 hrs by SEAP dependent NF-kappaB reporter assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at RXR-alpha in mouse RAW264.7 cells assessed as supression of bexarotene-induced inhibition of LPS-induced NF-kappaB transcription by measuring NF-kappaB level at 0.1 to 10 uM incubated for 24 hrs by SEAP dependent NF-kappaB reporter assay
Assay data:1 Tested
Agonist activity at RXR-alpha in mouse RAW264.7 cells assessed as inhibition of LPS-induced NF-kappaB transcription by measuring NF-kappaB level at 0.1 uM incubated for 24 hrs by SEAP dependent NF-kappaB reporter assay (Rvb = 1 No_unit)
Mouse Retinoid X receptor-alpha (2B. Retinoid X receptors)
Assay data:4 Active, 4 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Partial agonist activity at mouse RXRalpha expressed in COS1 cells by luciferase reporter gene assay relative to bexarotene
Assay data:2 Active, 2 Tested
Agonist activity at full length mouse FXR/RXRalpha expressed in human HEK293 cells assessed as induction of transcriptional activity after 18 hrs by dual luciferase reporter gene assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at full length mouse FXR/RXRalpha expressed in human HEK293 cells assessed as induction of transcriptional activity at 10 ug/mL after 18 hrs by dual luciferase reporter gene assay relative to control
Assay data:2 Active, 4 Tested
Agonist activity at RXRalpha in mouse peritoneal macrophages assessed as ApoAI-mediated cholesterol efflux in presence of 22(R)-hydroxycholesterol after 24 hrs by Western blotting
Agonist activity at RXRalpha in mouse peritoneal macrophages assessed as ApoAI-mediated cholesterol efflux after 24 hrs by Western blotting
Assay data:3 Active, 3 Tested
Transactivation of Gal4-LBD fused mouse RXRalpha (218 to 467) transfected in african green monkey CV1 cells assessed as luciferase activity at 2 uM after 6 hrs by Dual-light chemiluminescent assay relative to LGD1069
Transactivation of Gal4-LBD fused mouse RXRalpha (218 to 467) transfected in african green monkey CV1 cells assessed as luciferase activity at 2 uM after 6 hrs by Dual-light chemiluminescent assay relative to 9-cis-retinoic acid
Transactivation of Gal4-LBD fused mouse RXRalpha (218 to 467) transfected in african green monkey CV1 cells assessed as luciferase activity at after 6 hrs by Dual-light chemiluminescent assay
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of Gal4-LBD fused mouse RXRalpha transactivation in african green monkey CV1 cells at 1 uM after 6 hrs by Dual-light chemiluminescent assay
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