BioAssay by Target (List) for Gene (Select 20249) - PubChem BioAssay - NCBI

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Select item 14219791.

Inhibition of mouse liver microsome SCD assessed as reduction in [3H]H2O production using stearoyl [9,10-3H]CoA as substrate in presence of NADH incubated for 30 mins by scintillation counting method

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1421979

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14107302.

Inhibition of SCD1 in CD1 mouse liver at 3 uM using stearoyl [9,10-3H] CoA as substrate and NADPH incubated for 2 hrs by scintillation counting method

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:1 Tested

AID:: 1410730

Summary PubMed Citation Related BioAssays by Target

Select item 14107233.

Inhibition of SCD1 in CD1 mouse liver at 100 nM using stearoyl [9,10-3H] CoA as substrate and NADPH incubated for 2 hrs by scintillation counting method

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:8 Tested

AID:: 1410723

Summary PubMed Citation Related BioAssays by Target

Select item 12248284.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout

Source:: Iain Fraser

Assay data:762 Active, 16821 Tested

AID:: 1224828

Summary Related BioAssays by Same Project

Select item 12248265.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:1106 Active, 16821 Tested

AID:: 1224826

Summary Related BioAssays by Same Project

Select item 11902186.

Inhibition of SCD1 in ICR mouse liver microsome using [9,10 3H]- stearoyl-Coenzyme A substrate assessed as decreased production of tritiated water after 20 hrs by scintillation counting analysis

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:28 Active, 26 Activity ≤ 1 µM, 29 Tested

AID:: 1190218

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 10641397.

Inhibition of SCD1 in mouse liver microsomes

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:25 Active, 23 Activity ≤ 1 µM, 27 Tested

AID:: 1064139

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 10640308.

Inhibition of SCD1 in mouse liver microsomes

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:27 Active, 24 Activity ≤ 1 µM, 28 Tested

AID:: 1064030

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 10532089.

A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:788 Active, 16789 Tested

AID:: 1053208

Summary PubMed Citation

Select item 72194310.

Inhibition of SCD1 in ICR mouse liver microsome using [9,10 3H]- stearoyl-Coenzyme A substrate assessed as decreased production of tritiated water after 20 hrs by scintillation counting analysis

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:48 Active, 45 Activity ≤ 1 µM, 57 Tested

AID:: 721943

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 72120511.

Inhibition of mouse SCD1

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:1 Active, 1 Tested

AID:: 721205

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 69220312.

Inhibition of mouse SCD-1

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 692203

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 64713613.

Inhibition of mouse SCD1

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 647136

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 64064914.

Inhibition of mouse SCD-1

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 640649

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 59552115.

Inhibition of mouse liver microsome SCD1

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:7 Active, 8 Activity ≤ 1 µM, 11 Tested

AID:: 595521

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 53594616.

Inhibition of SCD1 in mouse microsome assessed as reduction in conversion of [14C]stearic acid to [14C]oleic acid after 30 mins

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:9 Active, 4 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested

AID:: 535946

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 45559917.

Inhibition of Scd1 in mouse liver microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 mins

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested

AID:: 455599

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 45500118.

Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 mins

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:23 Active, 4 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 28 Tested

AID:: 455001

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 43072819.

Inhibition of SCD1 in mouse microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 mins

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:22 Active, 7 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 29 Tested

AID:: 430728

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 42604920.

Inhibition of stearoyl-CoA desaturase 1 in mouse microsome assessed as conversion of [14C]stearate to [14C]oleate

Source:: ChEMBL

Protein Target:: Acyl-CoA desaturase 1

Assay data:16 Active, 2 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 20 Tested

AID:: 426049

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (17)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (5)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (16)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (17)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (19)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (3)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (19)
BioAssays extracted from the literature
Other (3)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 20249) (22)
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