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Inhibition of sEH (unknown origin)
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant sEH
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human sEH
Inhibition of recombinant human sEH expressed in baculovirus infected Sf9 cells using PHOME as substrate assessed as residual activity at 10 uM preincubated for 15 mins followed by substrate addition and measured after 60 mins by spectrofluorimetric method relative to control
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using [3H]1,3-diphenyl-trans-propene oxide as substrate assessed as inhibition constant incubated for 5 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity Biochemical interaction (Human soluble epoxide hydrolase inhibition) EUB0000542a EPHX2
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Biochemical interaction (Human soluble epoxide hydrolase inhibition) EUB0000541a EPHX2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Affinity On-target Cellular interaction (ELISA (inhibition of sEH in human Hep G2 cells)) EUB0000542a EPHX2
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant human sEH using CMNPC as substrate preincubated for 5 mins followed by substrate addition and measured every 30 sec for 10 mins for by fluorescence based assay
Assay data:6 Active, 3 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 9 Tested
Assay data:19 Active, 9 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 31 Tested
Inhibition of sEH (unknown origin) at 100 nM relative to control
Assay data:31 Tested
Inhibition of full-length human sEH (1 to 555 residues) expressed in Escherichia coli BL21 (DE3) using PHOME as substrate preincubated for 45 mins followed by substrate addition and measured after 45 mins by fluorescence based method
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human sEH BacMam transduced HEK293 cells assessed as reduction in 14,15-DHET formation using 14,15-EET as substrate preincubated for 30 mins followed by susbtrate addition and measured after 90 mins by fluorescence polarization assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to human full length sEH (1 to 555 residues) expressed in doxycycline-induced HEK293 cells at 300 nM incubated for 5 hrs by Hoechst 33342 staining based fluorescence microscopy
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of (1R,3S)-N-(4-methoxy-2-(trifluoromethyl)benzyl)-3-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)cyclohexane-1-carboxamide from NanoLuc-fused human sEH ( 1 to 555 residues) expressed in HEK293T cells incubated for 5 hrs by NanoBRET analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to NanoLuc-fused human sEH ( 1 to 555 residues) expressed in HEK293T cells incubated for 5 hrs in presence of (1R,3S)-N-(4-cyano-2-(trifluoromethyl)benzyl)-3-(4-methyl-6-(methylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarboxamide by NanoBRET analysis
Binding affinity to NanoLuc-fused human sEH ( 1 to 555 residues) expressed in HEK293T cells incubated for 5 hrs by NanoBRET analysis
Displacement of (1R,3S)-N-(4-methoxy-2-(trifluoromethyl)benzyl)-3-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)cyclohexane-1-carboxamide from human recombinant sEH incubated for 5 hrs by fluorescence polarization assay
Assay data:3 Tested
Inhibition of lipid phosphatase activity of N-terminal domain of human sEH
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