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Inhibition of human ALDH1A1 in presence of NAD+ by LC-MS/MS analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Inhibition of full length human ALDH1A1 using propionaldehyde as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins in presence of NAD by luminescence microplate reader analysis
Assay data:8 Tested
ALDH Assay Protocol from US Patent US11753371: "Disulfiram derivatives as ALDH1A1 and MAGL inhibitors"
Assay data:20 Active, 15 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human ALDH1A1
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human ALDH1A1 assessed as fluorescent enhancement checked in presence of NAD+ by fluorescence based assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ALDH1A1 (unknown origin)
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of human ALDH1A1 expressed in Escherichia coli BL21(DE3) pLys cell in presence of NAD+ by fluorescence based assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant human ALDH1A1 using propionaldehyde as a substrate incubated for 15 mins followed by substrate addition by fluorescence based spectrophotometric analysis
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of human ALDH1A1 using propionaldehyde as substrate in presence of NAD+ by UV-visible spectrophometric analysis
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Binding affinity to ALDH1 in human HepG2 cells at 100 uM incubated for 8 hrs by pull-down/Western blot analysis
Substrate activity at N-terminal-His6 tagged recombinant human ALDH1A1 at 10 uM in presence of NADH by fluorimetric analysis relative to hexanal
Assay data:5 Tested
Inhibition of N-terminal-His6 tagged recombinant human ALDH1A1 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluorimetric analysis
Inhibition of N-terminal-His6 tagged recombinant human ALDH1A1 assessed as remaining enzyme activity by measuring fluorescence of NADH using hexanal and NAD+ as substrate at 10 uM by fluorimetric analysis relative to control
Assay data:6 Tested
Inhibition of ALDH1A1 in human drug-tolerant MDA-MB-231/lapatinib cells assessed as after 24 hrs
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibiton Assay from US Patent US9320722: "Regulators of aldehyde dehydrogenase ALDH3A1 and related therapeutic methods"
Assay data:25 Active, 9 Activity ≤ 1 µM, 55 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
IC50 Determination from Article 10.1002/cbic.201300625: "Development of Selective Inhibitors for Human Aldehyde Dehydrogenase 3A1 (ALDH3A1) for the Enhancement of Cyclophosphamide Cytotoxicity."
Assay data:2 Active, 16 Tested
Inhibition of human ALDH1A1 assessed as NADH formation using propionaldehyde as substrate at 10 uM by spectrophotometry
Assay data:53 Tested
Inhibition of human ALDH1A1 assessed as NADH formation using propionaldehyde as substrate by spectrophotometry
Assay data:8 Active, 4 Activity ≤ 1 µM, 8 Tested
Inhibition of ALDH1A1 (unknown origin) assessed as inhibition of propionaldehyde oxidation
Inhibition of ALDH1A1 (unknown origin) in presence of dithiothreitol
Assay data:4 Tested
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