BioAssay by Target (List) for Gene (Select 21973) - PubChem BioAssay - NCBI

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Links from Gene

Items: 10

Select item 13461351.

Mouse DNA topoisomerase II alpha (5.99.1.2 DNA Topoisomerases)

Source:: IUPHAR/BPS Guide to PHARMACOLOGY

Protein Target:: DNA topoisomerase 2-alpha

Assay data:1 Active, 1 Tested

AID:: 1346135

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 12248282.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout

Source:: Iain Fraser

Assay data:762 Active, 16821 Tested

AID:: 1224828

Summary Related BioAssays by Same Project

Select item 12248263.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:1106 Active, 16821 Tested

AID:: 1224826

Summary Related BioAssays by Same Project

Select item 10532094.

A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Secondary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:207 Active, 1576 Tested

AID:: 1053209

Summary PubMed Citation

Select item 10532085.

A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:788 Active, 16789 Tested

AID:: 1053208

Summary PubMed Citation

Select item 5480856.

Ratio of compound to etoposide on inhibitory effect of mouse DNA topoisomerase 2

Source:: ChEMBL

Protein Target:: DNA topoisomerase 2-alpha

Assay data:1 Tested

AID:: 548085

Summary PubMed Citation Related BioAssays by Target

Select item 5480817.

Inhibition of mouse DNA topoisomerase 2-mediated supercoiled pBR322 DNA relaxation at 2.5 uM after 1 hr by agarose gel electrophoresis

Source:: ChEMBL

Protein Target:: DNA topoisomerase 2-alpha

Assay data:1 Active, 1 Tested

AID:: 548081

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 5480778.

Inhibition of mouse DNA topoisomerase 2-mediated supercoiled pBR322 DNA relaxation at 25 uM after 1 hr by agarose gel electrophoresis

Source:: ChEMBL

Protein Target:: DNA topoisomerase 2-alpha

Assay data:1 Tested

AID:: 548077

Summary PubMed Citation Related BioAssays by Target

Select item 4634639.

Inhibition of mouse DNA topoisomerase 2 assessed as relaxation of supercoiled pBR322 plasmid DNA after 1 hr by electrophoresis relative to etoposide

Source:: ChEMBL

Protein Target:: DNA topoisomerase 2-alpha

Assay data:15 Tested

AID:: 463463

Summary PubMed Citation Related BioAssays by Target

Select item 45310710.

Inhibition of topoisomerase 2 from mouse P388 cells assessed as relaxation of pBR322 DNA by agarose gel electrophoresis relative to etoposide

Source:: ChEMBL

Protein Target:: DNA topoisomerase 2-alpha

Assay data:8 Tested

AID:: 453107

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (2)
BioAssays with compounds reported as biologically active

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (2)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (2)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (6)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (4)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (6)
BioAssays extracted from the literature
Other (4)
BioAssays deposited by other experimentalists

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